Barzooka - Fighting against bar graphs for continuous data!


Barzooka is a deep convolutional neural network that screens publication PDFs and checks for bar graphs of continuous data and other common graphing issues. Many different data distributions can lead to the same bar graph and the actual data may suggest different conclusions from the summary statistics alone. Barzooka also detects more informative alternatives to bar graphs, like dot plots, box plots and histograms. This website shows the detection of bar graphs for continuous data in bioRxiv preprints. A screening pipeline retrieves new preprints on a daily basis and screens them for bar graphs for continuous data. Preprints with bar graph detection are highlighted (column 'parse status') as well as the detected pages (click on 'View results'). Future interventions are planned to inform the authors of preprints about better alternatives for bar graphs.

View Results Title Date Posted Paper Link Parse Status Authors notified?
Anti-proliferative effect of potential LSD1/CoREST inhibitors based on molecular dynamics model for treatment of SH-SY5Y neuroblastoma cancer cell line
Sustainable elk harvests in Alberta with increasing predator populations
#PeerReview from @EMBOPress of ???????? Structural basis for feedforward control in the PINK1/parkin pathway
Further antibody escape by Omicron BA.4 and BA.5 from vaccine and BA.1 serum
Non-equilibrium protein folding and activation by ATP-driven chaperones
Intrinsically disordered interaction network in an RNA chaperone revealed by native mass spectrometry
Multiplexed microfluidic platform for stem-cell derived pancreatic islet β cells
Native size exclusion chromatography-based mass spectrometry (SEC-MS) identifies novel components of the Heat Shock Protein 90-dependent proteome
Rates and spectra of de novo structural mutation in Chlamydomonas reinhardtii
Greater alteration of gut microbiota occurs in childhood obesity than adulthood obesity
Cytochrome expression shifts in Geobacter sulfurreducens to maximize energy conservation in response to changes in redox conditions
Conservation of spatiotemporal DNA replication origin and terminus segregation patterns in Sinorhizobium meliloti with re-engineered bi- and monopartite genomes
Rapid, in-patient adaptations of Legionella pneumophila to the human host
Uncovering Lasonolide A biosynthesis using genome-resolved metagenomics
A cryptic transcription factor regulates Caulobacter adhesin development
Secreted filarial nematode galectins modulate host immune cells
Enhancing the anti-tumor efficacy of Bispecific T cell engagers via cell surface glycocalyx editing
The interface of condensates of the hnRNPA1 low complexity domain promotes formation of amyloid fibrils
Structural characterization of a breast cancer-associated mutation in caveolin-1
Predictions of immunogenicity reveal potent SARS-CoV-2 CD8+ T-cell epitopes
Site-specific validation and quantification of RNA 2'-O-methylation by qPCR with RNase H
Limitations of qPCR to estimate DNA quantity: AnRFU method to facilitate inter-laboratory comparisonsfor activity level, and general applicability
Self-assembly and structure of a clathrin-independent AP-1:Arf1 tubular membrane coat
Derivation of the immortalized cell line-UM51-PrePodo-hTERT and its responsiveness to Angiotensin II and activation of RAAS
Artificially stimulating retrotransposon activity increases mortality and accelerates a subset of aging phenotypes in Drosophila
Using a reverse genetics system to generate recombinant SARS-CoV-2 expressing robust levels of reporter genes
Diversity, abundance, and host specificity of the human skin associated circular and single stranded DNA virome
Dynamic bimodality of curli expression in planktonic cultures of Escherichia coli is stabilized by cyclic-di-GMP regulation
A protocol for the use of cold plasma treatment to inhibit in vitro growth of Fusarium graminearum.
Anti-chemokine antibodies after SARS-CoV-2 infection correlate with favorable disease course
Intranasal pediatric parainfluenza virus-vectored SARS-CoV-2 vaccine candidate is protective in macaques
The SARS-CoV-2 spike protein binds and modulates estrogen receptors
Tissue-specific modifier alleles determine Mertk loss-of-function traits
Reduced Neutralization of SARS-CoV-2 Omicron Variant in Sera from SARS-CoV-1 Survivors after 3-dose of Vaccination
Modeling suggests that multiple immunizations or infections will reveal the benefits of updating SARS-CoV-2 vaccines
Single Nucleus RNA Sequencing of Human Pancreatic Islets In Vitro and In Vivo Identifies New Gene Sets and Three β-Cell Subpopulations with Different Transcriptional Profile
Glucocorticoid receptor activation during human microglial differentiation leads to genomic instability and senescence
Opsin-free optical neuromodulation and electrophysiology enabled by a soft monolithic infrared multifunctional neural interface
Unbiased proteomic and forward genetic screens reveal that mechanosensitive ion channel MSL10 functions at ER-plasma membrane contact sites in Arabidopsis thaliana
Time-efficient relaxation measurements by 31P MR fingerprinting in human brain at 7T
A Well-Characterized Polycistronic-Like Gene Expression System in Yeast
Male mate preference against tail-elongated females in the barn swallow
Single-Cell Transcriptome Analyses Reveal the Cell Diversity and Developmental Features of Human Gastric and Metaplastic Mucosa
Loss of heterozygosity spectrum varies with ploidy levels in natural yeast populations
Bayesian species distribution models integrate presence-only and presence-absence data to predict deer distribution and relative abundance.
CRISPR loss of function screening to identify genes involved in human primordial germ cell-like cells development
MPS1 localizes to microtubule-attached kinetochores and actively promotesmicrotubule release
Deconstructing cold-induced brown adipocyte neogenesis in mice
PP6-regulated Aurora A activity towards NDC80 limits mitotic spindle size to prevent micronucleation
Hetero-oligomerization of TDP-43 carboxy-terminal fragments with cellular proteins contributes to proteotoxicity
Deep mutational scanning of essential bacterial proteins can guide antibiotic development
Identification and characterisation of potent anti-MRSA phloroglucinol derivatives of Dryopteris crassirhizoma Nakai
Neuroanatomical and Functional Consequences of Oxytocin Treatment at Birth
Oxytocin activity in the Paraventricular and Supramammillary Nuclei of the Hypothalamus is Essential for Social Recognition Memory in Rats
Lasting consequences on physiology and social behavior following cesarean delivery in prairie voles
A critical role for touch neurons in a skin-brain pathway for stress resilience
Time Lagged Multidimensional Pattern Connectivity (TL MDPC): An EEG/MEG Pattern Transformation Based Functional Connectivity Metric
Lactate supply overtakes glucose when neural computational and cognitive loads scale up
Involvement of nucleus accumbens D2-MSN projections to the ventral pallidum in anxious-like behavior
Cooperative assembly confers regulatory specificity and long-term genetic circuit stability
Phenotypic variation and quantitative trait loci for resistance to southern anthracnose and clover rot in red clover
A Murine Model of Abductor Insufficiency Accelerates the Development of Hip Osteoarthritis
Contrasting parental roles shape sex differences in poison frog space use but not navigational performance
An iPSC library from a family with Creutzfeldt-Jakob disease caused by the E200K mutation
Tle4 controls both developmental acquisition and postnatal maintenance of corticothalamic projection neuron identity
#PeerReview from @eLife of ???????? Towards a molecular mechanism underlying mitochondrial protein import through the TOM-TIM23 complex
#PeerReview from @eLife of ???????? Asymmetry of cortical functional hierarchy in humans and macaques suggests phylogenetic conservation and adaptation
#PeerReview from @eLife of ???????? BrainPalmSeq: A curated RNA-seq database of palmitoylating and de-palmitoylating enzyme expression in the mouse brain 2021-12-06
#PeerReview from @eLife of ???????? Aberrant cortical development is driven by impaired cell cycle and translational control in a DDX3X syndrome model
Metabolic Implications of Birth via Cesarean Section in Prairie Vole (Microtus ochrogaster)
Biomolecular solution X-ray scattering at n2STAR Beamline
A survey of mapping algorithms in the long-reads era
Patterns of lineage-specific genome evolution in the brood parasitic black-headed duck (Heteronetta atricapilla)
Effects of altered cellular ultrastructure on energy metabolism in diabetic cardiomyopathy - an in-silico study
Post-injury hydraulic fracturing drives fissure formation in the zebrafish basal epidermal cell layer
A therapeutically targetable NOTCH1-SIRT1-KAT7 axis in T-cell Leukemia
Condensates of disordered proteins have small-world network structures and interfaces defined by expanded conformations
Improved antibody-specific epitope prediction using AlphaFold and AbAdapt
ExplaiNN: interpretable and transparent neural networks for genomics
Pathogen dependence and inter-individual variability of post-infection reproductive fitness in Drosophila melanogaster
Molecular evidence of chemical disguise by the socially parasitic spiny ant Polyrhachis lamellidens (Hymenoptera: Formicidae) when invading a host colony
Colony size frequency distribution across gradients of reef health in disturbed coral reefs in Northeast Peninsular Malaysia
Analysis of organelle content supports a membrane budding model of platelet biogenesis
Differential excretory/secretory proteome of the adult female and male stages of the human blood fluke, Schistosoma mansoni
Reliable detection of pyrazinamide antitubercular activity in vitro.
Identification of Potent CD43+ Effector CD8+ T cells Elicited After Transplantation
The 5-hydroxytryptaminergic Neurons Locating in the Dorsal Raphe Nucleus and Different Receptors of 5-HT Were Implicated in Mediating the Arousal from Sevoflurane Anesthesia
Targeting acetyl-CoA metabolism attenuates the formation of fear memories through reduced activity-dependent histone acetylation
A global atlas of substrate specificities for the human serine/threonine kinome
Twitter as a community communication tool for international neuroscience conferences
Transcriptional signature pattern in black, blue and purple wheat and impact on seed pigmentation and other associated features: Comparative transcriptomics, genomics and metabolite profiling
Incilius alvarius cell-based synthesis of 5-MeO-DMT
DNAscope: High accuracy small variant calling using machine learning
A modular intramolecular triplex photo-switching motif that enables rapid and reversible control of aptamer binding activity
An improved TurboID pipeline in C. elegans by biochemical depletion of endogenously biotinylated carboxylases
Spurious intragenic transcription is a hallmark of mammalian cellular senescence and tissue aging
A bifunctional kinase-phosphatase module integrates mitotic checkpoint and error-correction signalling to ensure mitotic fidelity
Immunoregulatory subtype of dermal lymphatic endothelial cells at capillary terminals drives lymphatic malformations
DEGRONOPEDIA - a web server for proteome-wide inspection of degrons
Metabolic shift toward ketosis in asocial cavefish increases social-like collective behavior.
Graph-based algorithms for Laplace transformed coalescence time distributions.
Interpreting the fossil record and the origination of birds
Development of fluoroquinolone resistance through antibiotic tolerance in Campylobacter jejuni
Inhibitory interneurons within the deep dorsal horn integrate convergent sensory input to regulate motor performance
Ecological Dynamics Imposes Fundamental Challenges in Microbial Source Tracking
Two therapeutic CRISPR/Cas9 gene editing approaches revert FTD/ALS cellular pathology caused by a C9orf72 repeat expansion mutation in patient derived cells
Breathing dysfunction and alveolar damage in a mouse model of Dravet syndrome
Lactational delivery of Triclosan promotes non-alcoholic fatty liver disease in newborn mice
The rise of sparser single-cell RNAseq datasets; consequences and opportunities
S. cerevisiae cells can grow without the Pds5 cohesin subunit
UHMK1 is a novel splicing regulatory kinase
Comparative genomic insights into the evolution of Halobacteria-associated "Candidatus Nanohaloarchaeota"
Purified cytosolic crystals from Bacillus thuringiensis as a novel active pharmaceutical ingredient (API)
Integration of metabolism and regulation reveals rapid adaptability to growth on non-native substrates.
Acute Vaping of a golden Syrian Hamster is Feasible and Leads to Nicotine-Dependent Respiratory Tract Inflammation
Mechanism of treatment-free remission in patients with chronic myeloid leukemia revealed by a computational model of CML evolution
Super-exponential growth and stochastic shape dynamics in rod-like bacteria
Surveying non-visual arrestins reveals allosteric interactions between functional sites
Probing the force-from-lipid mechanism with synthetic polymers
Lipid nanoparticle topology regulates endosomal escape and delivery of RNA to the cytoplasm
A comprehensive assay of social motivation reveals sex-differential roles of ASC-associated genes and oxytocin
Radiation and diversification of GATA-domain-containing proteins in the genus Caenorhabditis
Environmental DNA reveals invasive crayfish microbial associates and ecosystem-wide biodiversity before and after eradication
Nucleoli and the nucleoli-centromere association are dynamic during normal development and in cancer
Epitranscriptomic Modification of MicroRNA Increases Atherosclerosis Susceptibility
Butyrate differentiates permissiveness to Clostridioides difficile infection and influences growth of diverse C. difficile isolates
Somatic hypermutation spectra are independent of the local transcriptional and epigenetic landscape
Increased GABA transmission to GnRH neurons after intrahippocampal kainic acid injection in mice is sex-specific and associated with estrous cycle disruption
Retigabine Suppresses Loss of Force in a Mouse Model of Hypokalemic Periodic Paralysis
High-throughput, real-time monitoring of engineered skeletal muscle function using magnetic sensing
Robust alignment of single-cell and spatial transcriptomes with CytoSPACE
A GATA factor radiation in Caenorhabditis rewired the endoderm specification network
Cerebellum Directly Modulates the Substantia Nigra Dopaminergic Activity
Optimal population turnover regimes for cultural evolution depend on network size, density and behavioral transmissibility
Hematopoietic stem cells are a long-term reservoir for trained immunity in a mouse model of chronic autoimmune disease
Cortical circuits modulate mouse social vocalizations
Divergent projections from Locus Coeruleus to the cortico-basal ganglia system and ventral tegmental area of the zebra finch.
Local synaptic inhibition mediates cerebellar pattern separation necessary for learned sensorimotor associations
The petrous bone contains high concentrations of osteocytes: one possible reason why ancient DNA is better preserved in this bone.
Determination of heavy metals in blood of nesting Kemps Ridley turtles ( Lepidochelys kempii ) at Rancho Nuevo sanctuary, Tamaulipas, Mexico.
Mutation in the matricellular gene fibulin-4 leads to endothelial dysfunction in resistance arteries
The abundances and occurrences of foliar microbes are poorly predicted by variation in plant traits and abiotic conditions
AGS3 antagonizes LGN to balance oriented cell divisions and cell fate choices in mammalian epidermis
Lysogenized phages of methanotrophic bacteria show a broad and untapped genetic diversity
Mechanoreceptor signal convergence and transformation in the dorsal horn flexibly shape a diversity of outputs to the brain
The Adaptor Protein 2 (AP2) complex modulates habituation and behavioral selection across multiple pathways and time windows
A Remarkable Adaptive Paradigm Of Heart Performance And Protection Emerges In Response To The Constitutive Challenge Of Marked Cardiac-Specific Overexpression Of Adenylyl Cyclase Type 8
A Mesenchymal Cell Niche in Skin for Acute Myeloid Leukemia
Quantification and statistical modeling of Chromium-based single-nucleus RNA-sequencing data
Systematic Analysis of Mobile Genetic Elements Mediating β-lactamase Gene Amplification in Non-Carbapenemase-Producing Carbapenem Resistant Enterobacterales Bloodstream Infections
Emergent coexistence in multispecies microbial communities
Septin-Mediated RhoA Activation Engages the Exocyst Complex to Recruit the Cilium Transition Zone
Myriocin remodels sphingolipids and modulates proteostasis networks to enhance longevity
Repurposed drugs and their combinations prevent morbidity-inducing dermonecrosis caused by diverse cytotoxic snake venoms
PGC1β and ERRα promote glutamine metabolism and colorectal cancer survival via transcriptional regulation of PCK2
Oncogenic KRAS alters splicing factor phosphorylation and alternative splicing in lung cancer
Humanized CAR T cells targeting p95HER2
Epigenetic plasticity via adaptive DNA hypermethylation and clonal expansion underlie resistance to oncogenic pathway inhibition in pancreatic cancer
Buforin II-Escherichia coli's DNA interactome: Detailed biophysical characterization revealed nanoscale complexes likely formed by DNA supercoiling
Ratiometric NAD+ sensors reveal subcellular NAD+ modulators
Design of a mucin-selective protease for targeted degradation of cancer-associated mucins
Actin filaments couple the protrusive tips to the nucleus through the I-BAR domain protein IRSp53 for migration of elongated cells on 1D fibers
Sphingolipid depletion inhibits bulk endocytosis while triggering selective clearance of the methionine transporter Mup1
An apical protein, Pcr2, is required for persistent movement by the human parasite Toxoplasma gondii
Cell survival enabled by leakage of a labile metabolic intermediate
Heterologous Expression of NoxA Confers Aerotolerance in Clostridium sporogenes
Statistical significance and biological relevance: The case of Nosema ceranae and winter colony losses.
Differences in Gut Microbiota Assembly Alter Its Ability to Metabolize Dietary Polysaccharides and Resist Clostridioides difficile Colonization
Cytoplasmic TDP-43 accumulation drives changes in C-bouton number and size in a mouse model of sporadic Amyotrophic Lateral Sclerosis
Recognition of BRAF by CDC37 and Reevaluation of the Activation mechanism for the Class 2 BRAF-L597R mutant
Conformational Dynamics and Mechanisms of Client Protein Integration into the Hsp90 Chaperone Controlled by Allosteric Interactions of Regulatory Switches: Perturbation-Based Network Approach for Mutational Profiling ...
Characterization and structure of the human lysine-2-oxoglutarate reductase domain, a novel therapeutic target for treatment of glutaric aciduria type 1
Omicron breakthrough infections in vaccinated or previously infected hamsters
Structural basis for substrate selection by the SARS-CoV-2 replicase
The spike-stabilizing D614G mutation interacts with S1/S2 cleavage site mutations to promote the infectious potential of SARS-CoV-2 variants
Deep mutational scanning identifies SARS-CoV-2 Nucleocapsid escape mutations of currently available rapid antigen tests
SARS-CoV-2 Spike protein suppresses CTL-mediated killing by inhibiting immune synapse assembly
SARS-CoV-2 Infects Peripheral and Central Neurons of Mice Before Viremia, Facilitated by Neuropilin-1
Revealing druggable cryptic pockets in the Nsp-1 of SARS-CoV-2 and other β-coronaviruses by simulations and crystallography
Global predictions for the risk of establishment of Pierce's disease of grapevines
CRISPR-Cas provides limited phage immunity to a prevalent gut bacterium in gnotobiotic mice
Genome-wide association mapping reveals genes underlying population-level metabolome diversity in a fungal crop pathogen
Ephemeral Resource Availability Makes Wild Guppies More Social
Genome size changes by duplication, insertion and divergence in Caenorhabditis worms
The Batten disease protein CLN3 is important for stress granules dynamics and translational activity.
Structure of nucleosome-bound human PBAF complex
EZH2 interacts with MEG3 to directly regulate integrin signaling and endothelial cell function
Spatial memory training reverses GirK channels modulation in the transgenic APPSw,Ind Alzheimer's disease mouse model
Systematic evaluation of high level visual deficits and lesions in posterior cerebral artery stroke
Evidence for different greater-persistence strategies under lower and higher challenge for alcohol in female rats
Changes in Tissue Protein N-Glycosylation and Associated Molecular Signature Occur in the Human Parkinsonian Brain in a Region-Specific Manner
Artificial Alzheimer's - visualizing the process of memory decay, confusion and death in a simple Neural Network Model of Associative Memory
Computational conjugate adaptive optics for longitudinal through-skull imaging of cortical myelin
Rab11 regulates autophagy at dendritic spines in an mTOR- and NMDA-dependent manner
Minimally invasive delivery of peptides to the spinal cord for behavior modulation
Single cell analysis of the dorsal V-SVZ reveals differential quiescence of postnatal pallial and subpallial neural stem cells driven by TGFbeta/BMP-signalling
Connectivity by the Frontal Aslant Tract (FAT) explains local functional specialization of the superior and inferior frontal gyri in humans while choosing predictive over reactive strategies: a tractography-guided TMS ...
A Novel Strategy for Dynamic Modelling of Genome-Scale Interaction Networks
Rudimentary Structure-Activity-Relationship study of the MMV Pathogen Box compound MMV675968 (2,4-diaminoquinazoline) unveils novel inhibitors of Trypanosoma brucei brucei DHFR enzyme
Interplay between VSD, pore and membrane lipids in electromechanical coupling in HCN channels
Measuring single-virus fusion kinetics using an assay for nucleic acid exposure
Alignment-free metal ion-binding site prediction from protein sequence through pretrained language model and multi-task learning
Succinylated lysine residue prediction revisited
Correcting Modification-Mediated Errors in Nanopore Sequencing by Nucleotide Demodification and in silico Correction
Succinct k-mer Set Representations Using Subset Rank Queries on the Spectral Burrows-Wheeler Transform (SBWT)
Scalable power analysis and effect size exploration of microbiome community differences with Evident
recountmethylation enables flexible analysis ofpublic blood DNA methylation array data
Automated optimisation of solubility and conformational stability of antibodies and proteins
Bees differentiate sucrose solution from water at a distance
Host and pathogen drivers of infection-induced changes in social aggregation behavior
Molecular Phylogenetics of HIV-1 Subtypes in African Populations: A Case Study of Sub-Saharan African Countries
Metabolic, Fibrotic, and Splicing Pathways Are All Altered in Emery-Dreifuss Muscular Dystrophy Spectrum Patients to Differing Degrees
Geometric morphometric analysis reveals cranial shape divergence and asymmetry in extinct and extant species of big cats (Carnivora: Felidae)
Age-specific and Sex-specific Nectar and Pollen Use by a Butterfly Pollinator
Semi-field and surveillance data define the natural diapause timeline for Culex pipiens across the United States
Human primed and naive PSCs are both competent indifferentiating into bona fide trophoblast stem cells
Processing of task-irrelevant sounds during typical everyday activities in children
Drosophila embryos spatially sort their nutrient stores to facilitate their utilization
Novel insights into the pig gut microbiome using metagenome-assembled genomes
Competition-cooperation in the chemoautotrophic ecosystem of Movile Cave - first metagenomic approach on sediments
Pangenome evolution in Escherichia coli is sequence type, not phylogroup, specific
Narrowband gamma oscillations propagate and synchronize throughout the mouse thalamocortical visual system
The Queensland Twin Adolescent Brain Project, a longitudinal study of adolescent brain development
Model metamers illuminate divergences between biological and artificial neural networks
Variational and phase response analysis for limit cycles with hard boundaries, with applications to neuromechanical control problems
Gpr88 deletion impacts motivational control independently of striatal dopamine function
A single closed head injury in mice induces chronic, progressive white matter atrophy and increased phospho-tau expressing oligodendrocytes
Prelimbic cortex neural encoding dynamically tracks expected outcome value
Accurate speech decoding requires high-resolution neural interfaces
Whole-transcriptomic profiling of human cerebral cortex tissues reveals microglia-associated molecular subtypes
Coordination of Pickpocket ion channel delivery and dendrite growth in Drosophila sensory neurons
Maximum a posteriori natural scene reconstruction from retinal ganglion cells with deep denoiser priors
Hippocampus as a generative circuit for predictive coding of future sequences
Extended practice improves the accuracy and efficiency of goal-directed reaching guided by supplemental kinesthetic vibrotactile feedback
Temporal origin of mouse claustrum and development of its cortical projections
Super-resolved imaging deciphers ligand dependent membrane behaviour of the onco-immunogenic CCR5 receptor.
An Optimized Buffer for Repeatable Multicolor STORM
Computational modelling of local fluctuations causing transient solvent exposure of protein amides
Complexity of enhancer networks predicts cell identity and disease genes revealed by single-cell multi-omics analysis
Rapid estimation of cortical neuron activation thresholds by transcranial magnetic stimulation using convolutional neural networks
Goat kid recognition of their mothers' calls is not impacted by changes in source-filter parameters.
Direct and indirect phenotypic effects on sociability indicate potential to evolve
Insular holobionts: persistence and seasonal plasticity of the Balearic wall lizard (Podarcis lilfordi) gut microbiota
Brain morphometric changes in congenitally blind subjects: a 7 Tesla MRI study
Transient and sustained visuomotor selection during working-memory guided behavior.
Hindlimb Muscle Representations in Mouse Motor Cortex Defined by Viral Tracing
Parieto-frontal Oscillations Show Hand Specific Interactions with Top-Down Movement Plans
APOE modulates microglial immunometabolism in response to age, amyloid pathology, and inflammatory challenge
Spatial Transcriptomics-correlated Electron Microscopy
The limitations of phenotype prediction in metabolism
#PeerReview from @eLife of ???????? Multistep loading of PCNA onto DNA by RFC
#PeerReview from @ReviewCommons of ???????? The actin assembly requirements of the formin Fus1 to build the fusion focus
Root-specific activation of plasma membrane H+-ATPase 1 enhances plant growth and shoot accumulation of nutrient elements under nutrient-poor conditions in Arabidopsis thaliana
Conserved and variable responses of the HEAT SHOCK FACTOR transcription factor family in maize and Setaria viridis
Ter-Seq: A high-throughput method to stabilize transient ternary complexes and measure associated kinetics
Multivariate optimization of k for k-nearest-neighbor feature selection with dichotomous outcomes: complex associations, class imbalance, and application to RNA-Seq in Major Depressive Disorder
Higher-order interactions shape microbial interactions as microbial community complexity increases
Non-invasive vagus nerve stimulation in a hungry state decreases heart rate variability and wanting of a palatable drink
Study of the glycome of synovial mast cells in normal tissues, osteoarthritis and rheumatoid arthritis reveals MGAT5 activity in these and endochondral cells.
Periostin+ stromal cells guide lymphovascular invasion by cancer cells
A "cooperative collaboration" between HAND2 and MYCN shapes neuroblastoma cell identity
GRHL2 enhances phosphorylated estrogen receptor DNA-binding and regulates ER-mediated transcriptional activation and repression
Mechanosensor Piezo1 Mediates Bimodal Patterns of Intracellular Signaling
DProQ: A Gated-Graph Transformer for Protein Complex Structure Assessment
Detection of outlier methylation from bisulfite sequencing data with novel Bioconductor package BOREALIS
JEDII: Juxtaposition Enabled DNA-binding Interface Identifier
Convolutions are competitive with transformers for protein sequence pretraining
Spatially selective stimulation of the pig vagus nerve to modulate target effect versus side effect
#PeerReview from @eLife of ???????? LabNet: hardware control software for the Raspberry Pi
#PeerReview from @eLife of ???????? The mycobacterial mutasome: composition and recruitment in live cells
#PeerReview from @eLife of ???????? An M protein coiled coil unfurls and exposes its hydrophobic core to capture LL-37
#PeerReview from @eLife of ???????? Measurements of damage and repair in aging mice and humans reveals that robustness and resilience decrease with age, operate over broad timescales, and are affected differently by ...
#PeerReview from @eLife of ???????? Mettl3-mediated m6A modification of Fgf16 restricts cardiomyocyte proliferation during heart regeneration
A comparative study of structural variant calling strategies using the Alzheimer's Disease Sequencing Project's whole genome family data
Strength of selection potentiates distinct adaptive responses in an evolution experiment with outcrossing yeast
Population estimate, natural history and conservation of the melanistic Iguana iguana population on Saba, Caribbean Netherlands
Whole-genome scanning reveals selection mechanisms in epipelagic Chaetoceros diatom populations
Exploring the mosquito-arbovirus network: a survey of vector competence experiments
Scent mark signal investment predicts fight dynamics in house mice
Timed Notch Inhibition drives Photoreceptor fate specification in Human Retinal Organoids
mNeonGreen-tagged fusion proteins and nanobodies reveal localization of tropomyosin to patches, cables, and contractile actomyosin rings in live yeast cells
Oxidative Stress Induced Senescence Gives Rise to Transcriptionally Distinct Physiological States
Protein Lactylation and Metabolic Regulation of the Zoonotic Parasite Toxoplasma gondii
The contributory effects of the VH families and CH regions of multimeric IgM on its interaction with Fc(mu)R, and antigen.
Homeostatic changes maintain the gain control of spinal motoneurones across the lifetime of C57BL/6J mice
SARM1 promotes axonal, synaptic, and mitochondrial pathologies in Charcot-Marie-Tooth disease type 2A
Intelligibility improves the perception of speech rhythm
Developmental Coordination Disorder: What Can We Learn From Recombinant Inbred Mice Using Motor Learning Tasks and Quantitative Trait Locus Analysis
Nerve pathology is prevented by linker proteins in mouse models for LAMA2-related muscular dystrophy
The canonical Wnt signaling pathway is not a promising therapeutic target for PNS regeneration enhancement
Single-cell Ca2+ parameter inference reveals how transcriptional states inform dynamic cell fates
An electrogenetic toggle switch design
#PeerReview from @eLife of ???????? Control of Craniofacial Development by the Collagen Receptor, Discoidin Domain Receptor 2
The TERT promoter is polycomb-repressed in neuroblastoma cells with long telomeres
Effects of Familial Alzheimer's Disease Mutations on the Folding Free Energy and Dipole-Dipole Interactions of the Amyloid β-Peptide
Pangenomic genotyping with the marker array
A general framework for the combined morphometric, transcriptomic, and physiological analysis of cells using metric geometry
Confident Clustering via PCA Compression Ratio and ItsApplication to Single-cell RNA-seq Analysis
Quantitative Characterization of Duodenal Gastrinoma Autofluorescence using Multi-photon Microscopy
Creating a thermostable beta-glucuronidase switch for homogeneous immunoassay by disruption of conserved salt bridges at diagonal interfaces
Model-based intensification of CHO cell cultures: one-step strategy from fed-batch to perfusion
Oriented evening flight behaviour in the Bogong moth revealed through automated video tracking
Impaired Epigenesis of Imprinting Predispositions Causes Autism-like Behavioral Phenotypes in Domestic Chicks
Firefly-inspired vocabulary generator for communication in multi-agent systems
#PeerReview from @eLife of ???????? Structure of Mycobacterium tuberculosis Cya, an evolutionary ancestor of the mammalian membrane adenylyl cyclases
#PeerReview from @eLife of ???????? Integration of visual and antennal mechanosensory feedback during head stabilization in hawkmoths
#PeerReview from @eLife of ???????? Adaptation of Drosophila larva foraging in response to changes in food distribution
#PeerReview from @eLife of ???????? Endothelial-derived sphingolipids are required for vascular development and systemic lipid homeostasis
An update to the database for Acinetobacter baumannii capsular polysaccharide locus typing extends the extensive and diverse repertoire of genes found at and outside the K locus
Genetic, vocal, and body size divergence across the Northern Peruvian Low supports two species within the Masked Flowerpiercer (Diglossa cyanea)
Space-time home range estimates and resource selection for the Critically Endangered Philippine Eagle on Mindanao
Substantial seagrass blue carbon pools in the southwestern Baltic Sea are spatially heterogeneous, mostly autochthonous, and include relics of terrestrial peatlands
A social media-based framework for quantifying temporal changes to wildlife viewing intensity: Case study of sea turtles before and during COVID-19
Western diet-induced shifts in the maternal microbiome are associated with altered microRNA expression in baboon placenta and fetal liver
Sex-specific topological differences in germline cell lineage trees
Spatiotemporal dynamics of membrane surface charge regulates cell polarity and migration
Gene expression profiling reveals B cells are highly educated by the pancreatic environment during autoimmune diabetes
Dynamic Structure Of Motor Cortical Neuron Co-Activity Carries Behaviorally Relevant Information
Spatiotemporal organization of human sensorimotor beta burst activity
Bisected graph matching improves automated pairing of bilaterally homologous neurons from connectomes
AI-guided screen identifies probucol-mediated mitophagy enhancement through modulation of lipid droplets
Basic Leucine Zippers: Aureochromes Versus the Rest
Effect of pressure insole sampling frequency on peak force accuracy during running
Targeting TACC3 represents a novel vulnerability in highly aggressive breast cancers with centrosome amplification
Cell-to-cell variability of dynamic CXCL12-CXCR4 signaling and morphological processes in chemotaxis
Self-organized canals enable long range directed material transport in bacterial communities
Resolution doubling in light-sheet microscopy via oblique plane structured illumination
Metadata retrieval from genomics database with ffq
Serverless Prediction of Peptide Properties with Recurrent Neural Networks
TransCell: In silico characterization of genomic landscape and cellular responses from gene expressions through a two-step deep transfer learning
Guided construction of single cell reference for human and mouse lung
Characterizing metabolism from bulk and single-cell RNA-seq data using METAFlux
Characterizing transition cells in developmental processes from scRNA-seq data
A 512-ch dual-mode microchip for simultaneous measurements of electrophysiological and neurochemical activities
Brain-muscle connectivity during gait: corticomuscular coherence as quantification of the cognitive reserve
Delayed benefits for fallow bucks: more fights decrease same day mating success, but may increase matings the next day
A binocular perception deficit characterizes prey pursuit in developing mice
The largest haplotype-phased and chromosome-scale genome assembly of the fungal pathogen, Puccinia polysora, by HiFi reads and Hi-C data
Nucleotide resolution genetic mapping in pigs by publicly accessible whole genome imputation
pastclim: an R package to easily access and use paleoclimatic reconstructions
Museum specimens of a landlocked pinniped reveal recent loss of genetic diversity and unexpected population connections
Non-aging despite high mutation rate - genomic insights into the evolution of Hydra
Camera-based monitoring of Bogong moths in Alpine Australia reveals drivers of migratory behaviour
Wnt signalling, cell fate determination and anteroposterior polarity of the skate gill arch skeleton
ABHD6 selectively controls Gq-dependent increases in 2-AG production
Long-term functional regeneration of radiation damaged salivary glands through delivery of a neurogenic hydrogel
Mathematical modeling suggests that a single Plasmodium-specific CD8 T cell can eliminate a malaria liver stage in mice
Control of flight responses by a non-canonical corticolimbic pathway.
Larger cerebral cortex is genetically correlated with greater frontal area and dorsal thickness
The molecular fingerprint of stress resilience
Sparse RNNs can support high-capacity classification
Deep Learning-Based Parameter Estimation for Neurophysiological Models of Neuroimaging Data
QTL mapping for seed morphology using the instance segmentation neural network in Lactuca spp.
In-situ lipid profiling of insect pheromone glands by Direct Analysis in Real Time Mass Spectrometry
NON-TARGETED METABOLOMICS REVEAL DIFFERENCES IN THE METABOLIC PROFILE OF THE FALL ARMYWORM STRAINS WHEN FEEDING DIFFERENT FOOD SOURCES
A Preclinical Model to Investigate Normal Tissue Damage Following Fractionated Radiotherapy to the Head and Neck
Human intracranial pulsatility during the cardiac cycle: a computational modelling framework
A framework to trace microbial engraftment at the strain level during fecal microbiota transplantation
Reproducing extracellular matrix adverse remodelling of non-ST myocardialinfarction in a large animal model
Single molecule multi-omics reveals context-dependent regulation of enhancers by DNA methylation
Spatial and temporal diversity of positive selection on shared haplotypes at the PSCA locus among worldwide human populations
A comparison between Mini-loop mediated isothermal amplification and polymerase spiral reaction for selective amplification of short template DNA
Humans parsimoniously represent auditory sequences by pruning and completing the underlying network structure
Ancestral state reconstruction suggests repeated losses of recruitment communication during ant evolution (Hymenoptera: Formicidae)
3D flightpaths reveal the development of spatial memory in wild hummingbirds
Discovery and pre-clinical evaluation of antibodies to the NKG2A inhibitory receptor
Allosteric Inhibition of PTP1B by a Nonpolar Terpenoid
#PeerReview from @eLife of ???????? Modeling osteoporosis to design and optimize pharmacologic therapies comprising multiple drug types
#PeerReview from @eLife of ???????? Robust group- but limited individual-level (longitudinal) reliability and insights into cross-phases response prediction of conditioned fear
#PeerReview from @eLife of ???????? Locally synchronized ciliary domains and tissue-scale cilia alignment underlie global metachronal wave patterns
Disentangling the historical routes to community assembly in the global epicentre of biodiversity
The Microbiome and Volatile Organic Compounds Reflect the State of Decomposition in an Indoor Environment
The majority of microorganisms in gas hydrate bearing subseafloor sediments ferment macromolecules
Using nanopore sequencing to obtain complete genomes from saliva samples
Klebsiella pneumoniae L-Fucose metabolism promotes gastrointestinal colonization and modulates its virulence determinants
Distinct types of multicellular aggregates in Pseudomonas aeruginosa liquid cultures
A reproducible and tunable synthetic soil microbial community provides new insights into microbial ecology
PGC-1β maintains mitochondrial metabolism and restrains inflammatory gene expression
Aiolos modulates the TFH and CD4-CTL differentiation programs via reciprocal regulation of the Zfp831/TCF-1/Bcl-6 axis and CD25
Diverse task-driven modeling of macaque V4 reveals functional specialization towards semantic tasks
Precision motor timing via scalar input fluctuations
C5aR1 antagonism alters microglial polarization and mitigates disease progression in a mouse model of Alzheimers disease
Enhancer plasticity sustains oncogenic transformation and progression of B-Cell Acute Lymphoblastic leukemia.
Mechanism of Mg2+ Mediated Encapsulation of an Anionic Cognate Ligand in a Bacterial Riboswitch
Rdh54 stabilizes Rad51 at displacement loop intermediates to regulate genetic exchange between chromosomes
Membrane-Bound O-Acyltransferase 7 (MBOAT7)-Driven Lysophosphatidylinositol (LPI) Acylation in Adipocytes Contributes to Systemic Glucose Homeostasis
Comprehensive analysis of the effect of mRNA sequences on translation efficiency and accuracy
Overexpression screen of chromosome 21 genes reveals modulators of Sonic hedgehog signaling relevant to Down syndrome
High Frequency of Dynamic Rearrangements in CRISPR Loci
Expanded Distribution and Predicted Suitable Habitat for the Critically Endangered Yellow-tailed Woolly Monkey (Lagothrix flavicauda) in Peru
Mitochondrial genome recovery by ATFS-1 is essential for development following starvation
Effects of netarsudil-family Rho kinase inhibitors on human trabecular meshwork cell contractility and actin remodeling using a bioengineered ECM hydrogel
Combined omics unravels the molecular mechanism of golden-leaf coloration in Koelreuteria paniculata 'jinye'
A type IV Autotaxin inhibitor ameliorates acute liver injury and non-alcoholic steatohepatitis in mice
Held out wings RNA binding activity in the cytoplasm during early spermatogenesis
Functional gene analysis and cultivation experiments predict the degradation of diverse extracellular polysaccharides by ubiquitous taxa in pustular microbial mats from Shark Bay, Western Australia
The evolutionary potential of the influenza A virus hemagglutinin is highly constrained by intersegment epistasis
Targeting Nup358/RanBP2 by a viral protein disrupts stress granule formation
A Microfluidic Chip for LAMP-based Multiplex Detection of Pathogen
Lipopolysaccharide synthesis and traffic in the envelope of the pathogen Brucella abortus
The role of the environment in transmission of antimicrobial resistance between humans and animals: a modelling study
Host adaptation drives genetic diversity in a vector-borne disease system
Borg tandem repeats undergo rapid evolution and are under strong selection to create new intrinsically disordered regions in proteins
HIV positive patients on antiretroviral therapy have an altered mucosal intestinal but not oral microbiome
Programming the lymph node immune response with Amphiphile-CpG induces potent cellular and humoral immunity following COVID-19 subunit vaccination in mice and non-human primates
mRNA-based vaccines against SARS-CoV-2 do not stimulate interferon stimulatory gene expression in individuals affected by Aicardi Goutieres Syndrome.
The regulatory landscapes of human ovarian ageing
Dysfunction of transfer RNA modifications in inflammatory bowel disease
Fibroblasts-derived from Pluripotent Cells Harboring a Single Allele Knockout in Two Pluripotency Genes Exhibit DNA Methylation Abnormalities and pluripotency induction Defects
Zmiz1 is required for mature β-cell function and mass expansion upon high fat feeding
HiCUP-Plus: a fast open-source pipeline for accurately processing large scale Hi-C sequence data
The acute phase response in bats (Carollia perspicillata) varied with the time and dose of the immune-challenge
Collective directional migration drives the formation of heteroclonal cancer cell clusters
Curvature-induced cell rearrangements in biological tissues
Eulertigs: minimum plain text representation of k-mer sets without repetitions in linear time
DCAlign v1.0: Aligning biological sequences using co-evolution models and informative priors
COInr and mkCOInr: Building and customizing a non-redundant barcoding reference database from BOLD and NCBI using a lightweight pipeline.
Developmental timing of programmed DNA elimination in Paramecium tetraurelia recapitulates germline transposon evolutionary dynamics
Trait-dependent diversification in angiosperms: patterns, models and data
Serial depletion of Baltic herring since the Viking Age revealed by ancient DNA and population genomics
Profiles of secoiridoids and alkaloids in tissue of susceptible and resistant green ash progeny reveal patterns of induced responses to emerald ash borer in Fraxinus pennsylvanica
Using NAMs to characterize chemical bioactivity at the transcriptomic, proteomic and phosphoproteomic levels
Interplay between Polycomb PCGF protein interactomes revealed by screening under endogenous conditions
Cellular senescence in malignant cells promotes tumor progression in mouse and patient Glioblastoma
Increased CaMKK2 expression is an adaptive response that maintains the fitness of tumor-infiltrating natural killer cells
A method for morphological feature extraction based on variational auto-encoder : an application to mandible shape
PhiDsc: Protein functional mutation Identification by 3D Structure Comparison
Lack of evidence for increased transcriptional noise in aged tissues
Improved deterrence of birds using an artificial predator, the RobotFalcon
Extremely low level of genetic diversity in Gentiana yakushimensis, an endangered species in Yakushima Island, Japan
Massive Horizontal Gene Transfer in Amphioxus Illuminates the Early Evolution of Deuterostomes
Two different mental disc forms in the Tashan cave Garra: different species or ecotypes?
Soluble cyclase-mediated nuclear cAMP synthesis is sufficient for cell proliferation
Mating disrupts morning anticipation in Drosophila melanogaster females 2
Determination of cross-tissue and tissue-specific aging changes in murine proteomes
PPARγ/ETV2 Axis Regulates Endothelial-to-Mesenchymal Transition in Pulmonary Hypertension
Cross regulation between the molecular clock and kidney inflammatory, metabolic and fibrotic responses
Attention-aware contrastive learning for predicting T cell receptor-antigen binding specificity
Longitudinal white matter alterations in SIVmac239 infected rhesus monkeys with and without regular cART treatment
Pervasive gene duplications as a major evolutionary driver of coral biology
Highly Dynamic Gene Family Evolution Suggests Changing Roles for PON Genes Within Metazoa
Genetic diversity varies with species traits and latitude in predatory soil arthropods (Myriapoda: Chilopoda)
Comprehensive analysis of pathways in Coronavirus 2019 (COVID-19) using an unsupervised machine learning method
Voltage-Dependent Ca2+ Release Is Impaired in Hypokalemic Periodic Paralysis Caused by CaV1.1-R528H but not by NaV1.4-R669H
Pdx1 expression in hematopoietic cells activates Kras-mutation to drive leukemia in KC (Pdx1-Cre ; LSL-KrasG12D/+) mice
A computational proposal for tracking multiple molecules in a multi-focus confocal setup
Physical Obstacles Constrain Behavioral Parameter Space of Successful Localization in Honey Bee Swarms
Between heuristics and optimality: Flexible integration of cost and evidence during information sampling
COVID-19 lockdown reveals fish density may be much higher in marine reserves
The Wnt/TCF7L1 transcriptional repressor axis drives primitive endoderm formation by antagonizing naive and formative pluripotency
Prenatal valproic acid-induced autism marmoset model exhibits higher salivary cortisol levels
EDGE2: advancing the prioritisation of threatened evolutionary history for conservation action
Endothelial neuropilin-1 and neuropilin-2 are essential for tumour angiogenesis
scMoMaT: Mosaic integration of single cell multi-omics matrices using matrix trifactorization
Rtapas: An R package to assess cophylogenetic signal between two evolutionary histories
Conservation of nitrogenase functionality over long timescales
USP11 promotes endothelial apoptosis-resistance in pulmonary hypertension by deubiquitinating HINT3
Genomic screening reveals UBA1 as a potent and druggable target in c-MYC-high TNBC models
Extraintestinal roles of intestinal vitamin D receptor in protecting against dysbiosis and tumorigenesis in breast cancer
Ultra-small bispecific fusion protein augments tumor penetration and treatment efficacy for pancreatic cancer
MCell4 with BioNetGen: A Monte Carlo Simulator of Rule-Based Reaction-Diffusion Systems with Python Interface
Bayesian statistics improves biological interpretability of metabolomics data from human cohorts
INSISTC: Incorporating Network Structure Information for Single-Cell Type Classification
HARIBOSS: a curated database of RNA-small molecules structures to aid rational drug design
Semi-supervised deep learning with graph neural network for cross-species regulatory sequence prediction
Considerations for Deconvolution: A Case Study with GTEx Coronary Artery Tissues
Long-duration and non-invasive photoacoustic imaging of multiple anatomical structures in a live mouse using a single contrast agent
Cartilage-penetrating hyaluronic acid hydrogel preserves tissue content and reduces chondrocyte catabolism
The Effects of Negative Periocular Pressure on Biomechanics of the Optic Nerve Head and Cornea: A Computational Modeling Study
Plasticity of threespine stickleback nuptial signals: laboratory manipulation of ambient light causes a shift in male reflectance patterns.
Strain level centromere variation influences CENP-A association dynamics and centromere function
Domestication of different varieties in the cheese-making fungus Geotrichum candidum
Stronger sexual dimorphism in fruit flies may be favored when congeners are present and females actively search for mates
Evolution and diversification dynamics of butterflies
Cosmopolitan Scolytinae: strong common drivers but too many singularities for accurate prediction
Fruitful female fecundity after feeding Gryllodes sigillatus royal jelly
Microglia maintain homeostatic conditions in the developing rostral migratory stream.
Neural learning rules for generating flexible predictions and computing the successor representation
Self-generation of goal-directed choices in a distributed dopaminergic andprefrontal circuit
Glia-mediated cerebellar pain modulation
Associations between abstract working memory abilities and brain activity underlying long-term recognition of auditory sequences
Midbrain-Hippocampus Structural Integrity Selectively Predicts Motivated Memory Encoding
Disease-modifying effects of sodium selenate in a model of drug-resistant, temporal lobe epilepsy.
Second-generation transfer mediates efficient propagation of ICEBs1 in biofilms.
Disinhibition of Rab10 gates AMPAR insertion and spine enlargement during long-term potentiation
Boosting chloroplast ribosome biogenesis by a plastidial DEAD-box RNA helicase is critical for high light acclimation
OGG1 inhibitor TH5487 alleviates allergic airway inflammation in mice
ER translocation of suboptimal targeting sequences depends on Sec61β/Sbh1 and its phosphorylation
Homeostatic feedback between lysosomal mTORC1 and mTORC2-AKT signaling controls nutrient uptake in brown adipose tissue
Lung macrophages utilize cathepsin K-dependent phagosomal machinery to degrade intracellular collagen
The Nse5/6-like SIMC1-SLF2 Complex Localizes SMC5/6 to Viral Replication Centers
#PeerReview from @eLife of ???????? The giant Staphylococcus epidermidis surface protein Embp binds selectively to fibrillated fibronectin through a Velcro-like mechanism
#PeerReview from @eLife of ???????? Lifting the ban on nuclear import activates Gdown1-mediated modulation of global transcription and facilitates adaptation to cellular stresses
#PeerReview from @eLife of ???????? A single nucleotide variant in the PPARgamma-homolog Eip75B affects fecundity in Drosophila
Efficient querying of genomic databases for single-cell RNA-seq with gget
FliL has a conserved function in diverse microbes to negatively modulate motor output via its N-terminal region
The Indirect Pathway of the Basal Ganglia Promotes Negative Reinforcement, But Not Motor Suppression
Emergent low-frequency activity in cortico-cerebellar networks with motor skill learning
Molecular cloning and recombinant protein expression of 9-Lipoxygenase gene from Solanum tuberosum in Pichia pastoris yeast cells
Distinct nano-structures support a multifunctional role of actin at presynapses
Analysis of the Drosophila Ajuba LIM protein defines functions for distinct LIM domains
On the intrinsic curvature of animal whiskers
Modeling clonal evolution and oncogenic dependency in vivo in the context of hematopoietic transformation
The archaeological potential of the northern Luangwa Valley, Zambia: the Luwumbu basin.
Persistence of phenotypic responses to short-term heat stress in the tabletop coral Acropora hyacinthus
#PeerReview from @EMBOPress of ???????? UPF3A and UPF3B are redundant and modular activators of nonsense-mediated mRNA decay in human cells
A multi-domain connector links the outer membrane and cell wall in deep-branching bacteria
#PeerReview from @eLife of ???????? CyTOF-Lec: Single-cell glycomics analysis reveals glycan features defining cells differentially susceptible to HIV
Jak2V617F Reversible Activation Shows an Essential Requirement for Jak2V617F in Myeloproliferative Neoplasms
Transcriptome profile and clinical characterization of ICOS expression in brain gliomas
Chemoproteomics-Enabled Discovery of a Covalent Molecular Glue Degrader Targeting NF-κB
Extensive mosaicism by somatic L1 retrotransposition in normal human cells
The epigenomic landscape of single vascular cells reflects developmental origin and identifies disease risk loci
ERK pathway activation inhibits ciliogenesis and causes defects in motor behavior, ciliary gating, and cytoskeletal rearrangement
Carbon signaling protein SbtB possesses redox-regulated apyrase activity to facilitate regulation of bicarbonate transporter SbtA
An evolutionary paradigm favoring crosstalk between bacterial two-component signaling systems
Analysis of Cyp51 protein sequences shows 4 major Cyp51 gene family groups across Fungi
Limited Cross-Species Virus Transmission in a Spatially Restricted Coral Reef Fish Community
ParA and its functions that go beyond chromosome segregation in Caulobacter crescentus
Growth, organic matter release, aggregation and recycling during a diatom bloom: A model-based analysis of a mesocosm experiment
Gut microbiota of homing pigeons shows summer-winter variation under constant diet indicating a substantial effect of temperature
A dynamic HIF1alpha-PPARgamma circuit controls a paradoxical adipocyte regulatory landscape
Increasing protein stability by inferring substitution effects from high-throughput experiments
Lipidomic change in Aedes aegypti female following blood feeding reveals similar changes in functionally related lipids
Phenol Sensing in Nature Modulated via a Conformational Switch Governed by Dynamic Allostery
Structural analysis of cholesterol binding and sterol selectivity by ABCG5/G8
Impact of genus (Geotrigona, Melipona, Scaptotrigona) in the 1H-NMR organic profile and authenticity test of honey processed in cerumen pots by stingless bees in Ecuador
Genomic epidemiology and multilevel genome typing of Australian Salmonella enterica serovar Enteritidis
Rap1 uses Canoe-dependent and Canoe-independent mechanisms to regulate apical contractility and allow embryonic morphogenesis without tissue disruption
Disruption of Smarce1, a component of the SWI/SNF chromatin remodeling complex, decreases nucleosome stability in mouse embryonic stem cells and impairs differentiation
Mutant huntingtin exon-1 impaired GTPCH and DHFR expression in plants and mice
Chromosome folding and prophage activation reveal gut-specific genome dynamics of bacteria in the OMM12 consortium
Bacteroides muris sp. nov. isolated from the cecum of wild-derived house mice
wrmXpress: A modular package for high-throughput image analysis of parasitic and free-living worms
Analyses of circRNA expression throughout circadian rhythm reveal a strong link between Cdr1as and light-induced phase shifts in the SCN
Structure-Guided Identification of Critical Residues in the Vacuolar Na+,K+/H+ Antiporter NHX1 from Arabidopsis thaliana
Faunal remains from the Upper Paleolithic site of Nahal Rahaf 2 in the southern Judean Desert, Israel
Multi-contact statistics distinguish models of chromosome organization
Dendritic cell Piezo1 integrating mechanical stiffness and inflammatory signals directs the differentiation of TH1 and Treg cells in cancer
Myeloid cell evolution uncovered by shrimp immune cell analysis at single-cell resolution
Adaptation of bacterial proteome reveals a key role of the cell envelope in starvation survival
Single cell kinetic modeling of redox-based drug metabolism in head and neck squamous cell carcinoma
Maize immune signalling peptide ZIP1 evolved de novo from a retrotransposon
A conserved enzyme of smut fungi facilitates cell-to-cell movement in the plant bundle sheath
stainlib: a python library for augmentation and normalization of histopathology H&E images
Comprehensive and standardized benchmarking of deep learning architectures for basecalling nanopore sequencing data
Comparative genomics of five Valsa species gives insights on their pathogenicity evolution
ERnet: a tool for the semantic segmentation and quantitative analysis of endoplasmic reticulum topology for video-rate super-resolution imaging
Genome dynamics in mosses: Extensive synteny coexists with a highly dynamic gene space
Long-term adaptation to galactose as a sole carbon source selects for mutations in nutrient signaling pathways
Skewness in bee and flower phenological distributions
The Necrosis- and Ethylene-inducing peptide 1-like protein (NLP) gene family of the plant pathogen Corynespora cassiicola
The Clinical Response of Upadacitinib and Risankizumab is Associated with Reduced Inflammatory Bowel Disease Anti-TNFα Inadequate Response Mechanisms
A deeply conserved protease, acylamino acid-releasing enzyme (AARE), acts in plant aging
SARS-CoV-2 Subunit Virus-Like Vaccine Demonstrates High Safety Profile and Protective Efficacy: Preclinical Study
Radiation-Induced Metabolic Reprogramming of Fibroblasts Regulates the Breast Cancer Microenvironment
Substrate adhesion determines migration during mesenchymal cell condensation in chondrogenesis
Using unsupervised learning algorithms to identify essential genes associated with SARS-CoV-2 as potential therapeutic targets for COVID-19
Adaptation-proof SARS-CoV-2 vaccine design
Immunomodulatory Extracellular Matrix Hydrogel Mitigates Scar Formation in a Model of Tongue Fibrosis.
SARS-CoV-2 ORF1abA1061S potentiate autoreactive T cell responses via epitope mimicry: an explanation to hepatitis of unknown cause
Molecular analysis of a public cross-neutralizing antibody response to SARS-CoV-2
Machine Learning Reveals The Effect of Maternal Age on The Mouse Pre-Implantation Embryo Developmental Timing
Parallel measurement of transcriptomes and proteomes from same single cells using nanodroplet splitting
Thermopriming-associated proteome and sugar content responses in Pinus radiata embryogenic tissue
Selenocysteine metabolism is a targetable vulnerability in MYCN-amplified cancers
Menin-MLL Inhibitor MI-503 Blocks Menin Nuclear Export and Suppresses Hypergastrinemia
Interplay between cell height variations and planar pulsations in epithelial monolayers
Striosomes constrain locomotor vigor with respect to an innate valence differential
Visual experience has opposing influences on the quality of stimulus representation in adult primary visual cortex
The vestibular calyceal junction is dismantled in response to diverse injuring stimuli in rats and humans
Inferring Neural Activity Before Plasticity: A Foundation for Learning Beyond Backpropagation
Improvement of sensory deficits in Fragile X mice by increasing cortical interneuron activity after the critical period
Maintaining a stable head direction representation in naturalistic visual environments
A neural theory for counting memories
Short-term monocular deprivation boosts neural responsiveness to audio-visual events for the undeprived eye
Intermittent systemic exposure to lipopolysaccharide-induced inflammation disrupts hippocampal long-term potentiation and impairs cognition in aging male mice
Benefits of global mutant huntingtin lowering diminish over time in a Huntington's disease mouse model
Botrytis cinerea infection accelerates ripening and cell wall disassembly to promote disease in tomato fruit
Interactive Neurorobotics: Behavioral and Neural Dynamics of Agent Interactions
Modulation of Spindle Assembly Checkpoint efficiency by cell fate in a chordate embryo
Tracking and perceiving diverse motion signals: Directional biases in human smooth pursuit and perception
Late-onset glaucoma in Yap conditional knockout mouse
Simulation of the effect of the randomness of climbing fiber input on the relationship between motor learning and Focal Task-Specific Dystonia
Evolution of a Plastic Surgery Summer Research Program
3D-multiple immunoimaging using whole male organs in rice
Integration of multi-omics data shows downregulation of mismatch repair, purin, and tublin pathways in AR-negative triple-negative chemotherapy-resistant breast tumors
A comprehensive investigation of statistical and machine learning approaches for predicting complex human diseases on genomic variants
Detecting cell type from single cell RNA sequencing based on deep bi-stochastic graph regularized matrix factorization
A high-throughput test of anxiety for zebrafish (Danio rerio) larvae: the larval diving response (LDR)
Adaptation to ER-stress via serine glycine metabolism licences STING signalling and CMV control in intestinal epithelial cells
Therapeutic neutralizing monoclonal antibody administration protects against lethal viscerotropic Yellow Fever infection
TOB is an effector of the hippocampus-mediated acute stress response
Ptr1 and ZAR1 immune receptors confer overlapping and distinct bacterial pathogen effector specificities
The gradient-based parameter optimization to determine membrane ionic current composition of human induced pluripotent stem cell-derived cardiomyocytes
Evaluation of the DBA/2J mouse as a potential background strain for genetic models of cardiomyopathy
MFGE8 links absorption of dietary fatty acids with catabolism of enterocyte lipid stores through HNF4 γ- dependent transcription of CES enzymes
Two snakebite antivenoms have potential to reduce Eswatini's dependency upon a single, increasingly unavailable product: results of preclinical efficacy testing
Hippocampal β-adrenergic system modulates recognition memory reconsolidation
Quantifying Visual Acuity for Pre-Clinical Testing of Visual Prostheses.
Protective geometry and reproductive anatomy as candidate determinants of clutch size variation in pentatomid bugs
An algorithm for the identification of indicator taxonomic units and their use in analyses of ecosystem state
Alteration of Soil Bacteriome by Prolonged Exposure to Metal Oxide Nanoparticles
Re-direction of phagosomes to the recycling expulsion pathway by a fungal pathogen
Anthrax intoxication reveals that ER-Golgi membrane contact sites control the formation of plasma membrane lipid nanodomains
Inactivation of Vascular Stem Cells Suppresses Intimal Hyperplasia in Vein Grafts
Mindin differentially regulates fibroblast subpopulations via distinct members of the Src family kinases during fibrogenesis.
Actin limits egg aneuploidies associated with female reproductive aging.
High-fidelity optical diffraction tomography of live organisms using non-toxic tunable refractive index media
#PeerReview from @eLife of ???????? Human hippocampal responses to network stimulation vary with theta phase
#PeerReview from @ReviewCommons of ???????? Circadian regulation of the transcriptome in a complex polyploid crop
#PeerReview from @eLife of ???????? Spatial modeling reveals nuclear phosphorylation and subcellular shuttling of YAP upon drug-induced liver injury
#PeerReview from @eLife of ???????? Conditional Freezing, Flight and Darting?
#PeerReview from @eLife of ???????? Integration of computational modeling and quantitative cell physiology reveals central parameters for the brassinosteroid-regulated elongation growth along the axis of the Arabidopsis root
#PeerReview from @eLife of ???????? Homotopic contralesional excitation suppresses spontaneous circuit repair and global network reconnections following ischemic stroke
#PeerReview from @eLife of ???????? Recombinant single-cycle influenza virus as a new tool to augment antitumour immunity with immune checkpoint inhibitors
#PeerReview from @eLife of ???????? Network design principle for robust oscillatory behaviors with respect to biological noise
Long divergent haplotypes introgressed from wild sheep are associated with distinct morphological and adaptive characteristics in domestic sheep
Whole-brain computation of cognitive versus acoustic errors in music
The Proteomic Landscape of Genome-Wide Genetic Perturbations
Assessing PDB Macromolecular Crystal Structure Confidence at the Individual Amino Acid Residue Level
Simulating structurally variable Nuclear Pore Complexes for Microscopy
Single cell analysis reveals the molecular signaling and cellular composition of the regenerating Hydra head
Identifying novel regulators of placental development using time series transcriptomic data and network analyses
Transcription factors that specify cell fate activate cell cycle regulator genes to determine cell numbers in ascidian larval tissues
Zygotic genome activation by the totipotency pioneer factor Nr5a2
The circadian clock mediates daily bursts of cell differentiation by periodically restricting cell differentiation commitment
Intracellular Calcium links Milk Stasis to Lysosome Dependent Cell Death during Mammary Gland Involution
Comparison of simple RNA extraction methods for molecular diagnosis of hepatitis C virus in plasma
Enterococcus faecalis and Staphylococcus aureus mixed species infection attenuates pathogen-specific neutrophil responses and impairs bacterial clearance
Investigating And Modeling the Factors that Effects the Performance of Genetic Circuits
Identification of Three Medically Important Mosquito Species Using Raman Spectroscopy
A structural basis for prion strain diversity
Nature-Inspired Chemical Probes for in-cell Labeling of Lipidized RNA and Identification of New Regulatory Enzymes
The evolution of fitness effects during long-term adaptation in bacteria
Activity of Tricyclic Pyrrolopyrimidine Gyrase B Inhibitor against Mycobacterium abscessus
Liver humanized NSG-PiZ mice support the study of chronic hepatitis B virus infection and antiviral therapies
Zidovudine multi-combos with last-line fosfomycin, ceftazidime-avibactam, colistin and tigecycline against Multi-Drug Resistant Klebsiella pneumoniae
Enhanced flavour profiles through radicicol induced genomic variation in S. pastorianus lager yeast
Proteins released into the plant apoplast by the obligate parasitic protist Albugo selectively repress phyllosphere-associated bacteria
All Staphylococcus aureus bacteraemia strains have the potential to cause infective endocarditis: results of GWAS and experimental animal studies
Structure Activity Relationship of the Stem Peptide in Sortase A mediated Ligation from Staphylococcus aureus
Leishmania infection-derived extracellular vesicles drive transcription of genes involved in M2 polarization.
Lipopolysaccharide-mediated resistance to host antimicrobial peptides and hemocyte-derived reactive-oxygen species are the major Providencia alcalifaciens virulence factors in Drosophila melanogaster
X-ray imaging of 30 year old wine grape wood reveals cumulative impacts of rootstocks on scion secondary growth and harvest index
Functional regulation of 4D metabolic network between multienzyme glucosome condensates and mitochondria
Simulations of Pathogenic E1α Variants: Allostery and Impact on Pyruvate Dehydrogenase Complex-E1 Structure and Function
D-2-Hydroxyglutarate dehydrogenase connects the propionate shunt to ketone body metabolism in Caenorhabditis elegans
Cryo-EM structure of the agonist-bound Hsp90-XAP2-AHR complex
Serine Racemase is a Cysteine Racemase and Physiologic Down Regulator of Insulin Promoter Methylation
Clonally selected lines after CRISPR/Cas editing are not isogenic
Parallel changes in gene essentiality over 50,000 generations of evolution
RNA sequence to structure analysis from comprehensive pairwise mutagenesis of multiple self-cleaving ribozymes
CRISPR/Cas9-Mediated Excision of ALS/FTD-Causing Hexanucleotide Repeat Expansion in C9ORF72 rescues major disease mechanisms in vivo and in vitro
Spontaneous genomic variation as a survival strategy of nosocomial S. haemolyticus
Pig manure treatment strategies for mitigating the spread of antibiotic resistance
Anaerobic degradation of acid red 73 by obligately aerobic Aspergillus tabacinus LZ-M though a self-redox mechanism
In-vivo detection of cyclic-di-AMP in Staphylococcus aureus
Reemergence of the Murine Bacterial Pathogen Chlamydia muridarum in Laboratory Mouse Colonies
Enhancement of Cell Adhesion by Anaplasma phagocytophilum Nucleolin-interacting Protein AFAP
The ATLAS™ screening assay reveals distinct CD4+ and CD8+ SARS-CoV-2 antigen response profiles which have implications to Omicron cellular immunity
A study of a diauxic growth experiment using an expanded dynamic flux balance framework
Mathematical Characterization of Private and Public Immune Repertoire Sequences
Machine Learning Predicts Treatment Response in Bipolar & Major Depressive Disorders
Maturation kinetics of phagosomes depends on their transport switching from actin to microtubule tracks
A curated human cellular microRNAome based on 196 primary cell types
A unified urban green infrastructure classification for assessing ecosystem services and biodiversity
Phage resistance profiling identifies new genes required for biogenesis and modification of the corynebacterial cell envelope
Retina Gap Junction Networks Facilitate Blind Denoising in Visual Hierarchy
Network Topology Metrics Explaining Enrichment of Hybrid Epithelial Mesenchymal Phenotypes in Metastasis
Enzymatically-active bacterial microcompartments follow substrate gradients and are protected from aggregation in a cell-free system
In-Vitro Efficacy of Targeted FODMAP Enzymatic Digestion in a High-Fidelity Simulated Gastrointestinal Environment
Structural disruption of BAF chromatin remodeller impairs neuroblastoma metastasis by reverting an invasiveness epigenomic program
Targeting advanced prostate cancer with STEAP1 chimeric antigen receptor T cell therapy
Rabphilin 3A binds the N-peptide of SNAP-25 to promote SNARE complex assembly in exocytosis
Topology Adaptive Graph Convolution Network With Heterogeneous Entities For Predicting Adverse Events from Drug-Drug-Interactions
Evaluating trait-based sets for taxonomic enrichment analysis applied to human microbiome data sets
De Novo Protein Fold Design Through Sequence-Independent Fragment Assembly Simulations
Choice of 3D morphometric method leads to diverging interpretations of form--function relationships in the carnivoran calcaneus
From first principles to structure and function of unicellular plankton communities
Quantitative analysis of three-dimensional cell organisation and concentration profiles within curved epithelial tissues
Post-transcriptional control of SRSF9 promotes the epithelial-to-mesenchymal transition (EMT) in colorectal cancer cells
PRR14 organizes H3K9me3-modifed heterochromatin at the nuclear lamina
Variation in the ACE2 receptor has limited utility for SARS-CoV-2 host prediction
A kinetic basis for curvature sensing by septins
Predicting 3D RNA structure from solely the nucleotide sequence using Euclidean distance neural networks
Unsupervised outlier detection applied to SARS-CoV-2 nucleotide sequences can identify sequences of common variants and other variants of interest
YAP promotes cell-autonomous immune responses to tackle intracellular Staphylococcus aureus in vitro
CD133+ Intercellsome Mediates Direct Cell-Cell Communication to Offset Intracellular Signaling Deficit
CHIP ubiquitin ligase is involved in the nucleolar stress management
Membrane stretching activates calcium-permeability of putative fission yeast Pkd2 channel
Kynurenic acid, a key L-tryptophan-derived metabolite, protects the heart from an ischemic damage
Differential Evasion of Delta and Omicron Immunity and Enhanced Fusogenicity of SARS-CoV-2 Omicron BA.4/5 and BA.2.12.1 Subvariants
Prophylactic treatment of Glycyrrhiza glabra mitigates COVID-19 pathology through inhibition of pro-inflammatory cytokines in the hamster model and NETosis.
SARS-CoV-2 accessory proteins ORF7a and ORF3a use distinct mechanisms to downregulate MHC-I surface expression
Assessment of 3D MINFLUX data for quantitative structural biology in cells revisited
Primary cilia regulate Meibomian glands development and dimensions without impairing the lipid composition of the meibum
Pathogenic TDP-43 Disrupts Axon Initial Segment Structure and Neuronal Excitability in a Human iPSC Model of ALS
Cachd1 is a novel Frizzled- and LRP6-interacting protein required for neurons to acquire left-right asymmetric character
An automated high-content synaptic phenotyping platform in human neurons and astrocytes reveals a role for BET proteins in synapse assembly
Action initiation and punishment learning differ from childhood to adolescence while reward learning remains stable
Brain-wide imaging of an adult vertebrate with image transfer oblique plane microscopy
MAGScoT - a fast, lightweight, and accurate bin-refinement software
Highly efficient genome editing in barley using novel LbCas12a variants and impact of sgRNA architecture
Chromosome-level Reference Genome Provides Insights into Divergence and Stress Adaptation of the African Oil Palm
MaLAdapt reveals novel targets of adaptive introgression from Neanderthals and Denisovans in worldwide human populations
Evidence for correlated Eeolution of sexual selection and pseudogenization in primate fertilization
#PeerReview from @eLife of ???????? Cortical adaptation to sound reverberation
#PeerReview from @eLife of ???????? Ancestral reconstruction of duplicated signaling proteins reveals the evolution of signaling specificity
#PeerReview from @eLife of ???????? Motor processivity and speed determine structure and dynamics of microtubule-motor assemblies
Near-chromosomal de novo assembly of Bengal tiger genome reveals genetic hallmarks of apex-predation
A CRISPR-screen in intestinal epithelial cells identifies novel factors for polarity and apical transport
A new paradigm for personal protection against ticks: efficacy of spatial repellents to reduce host seeking activities in three major tick species of medical importance
Toxic effects of elevated bile acid levels on fetal myocardium in intrahepatic cholestasis of pregnancy?from a neonatal perspective
#PeerReview from @ReviewCommons of ???????? TORC1, BORC, and ARL-8 cycling drive vesiculation of cell corpse phagolysosomes
3D Chromatin Structure in Chondrocytes Identifies Putative Osteoarthritis Risk Genes
Developmentally determined intersectional genetic strategies to dissect adult somatosensory circuit function
Carbon footprint of South Dakota dairy production system and assessment of mitigation options
AT-hook DNA-binding motif-containing protein one knockdown downregulates EWS-FLI1 transcriptional activity in Ewings sarcoma cells
Aspergillus fumigatus can exhibit persistence to the fungicidal drug voriconazole
#PeerReview from @eLife of ???????? A pulse-chasable reporter processing assay for mammalian autophagic flux with HaloTag
#PeerReview from @eLife of ???????? Drosophila gustatory projections are segregated by taste modality and connectivity
#PeerReview from @eLife of ???????? Magnetic Stimulation Allows Focal Activation of the Mouse Cochlea
#PeerReview from @eLife of ???????? Anatomical connectivity along the anterior-posterior axis of the human hippocampus: new insights using quantitative fibre-tracking.
#PeerReview from @eLife of ???????? Conserved structural elements specialize ATAD1 as a membrane protein extraction machine
#PeerReview from @eLife of ???????? Timely sleep coupling: spindle-slow wave synchrony is linked to early amyloid-β burden and predicts memory decline
#PeerReview from @eLife of ???????? Non-cancer stem cell-derived Fibromodulin activates Integrin-dependent Notch signaling in endothelial cells to promote tumor angiogenesis and growth
#PeerReview from @eLife of ???????? Unleashing a Novel Function of Endonuclease G in Mitochondrial Genome Instability
#PeerReview from @eLife of ???????? Lung evolution in vertebrates and the water-to-land transition
#PeerReview from @eLife of ???????? Niche-specific genome degradation and convergent evolution shaping Staphylococcus aureus adaptation during severe infections
#PeerReview from @eLife of ???????? Self-organization of in vitro neuronal assemblies drives to complex network topology
#PeerReview from @eLife of ???????? The rapid developmental rise of somatic inhibition disengages hippocampal dynamics from self-motion
#PeerReview from @eLife of ???????? Contribution of behavioural variability to representational drift
#PeerReview from @eLife of ???????? Alveolar regeneration following viral infection is independent of tuft cells
Isolation of bat sarbecoviruses of SARS-CoV-2 clade, Japan
Functional evolution of SARS-COV-2 Spike protein: adaptation on translation and infection via surface charge of spike protein
Extensive lineage-specific rediploidisation masks shared whole genome duplication in the sturgeon-paddlefish ancestor
Human Surfactant Protein D Facilitates SARS-CoV-2 Pseudotype Binding and Entry in DC-SIGN Expressing Cells, and Downregulates Spike protein Induced Inflammation
Imaging unlabeled axons in the mouse retina by second harmonic generation
Two independent loss-of-function mutations in anthocyanidin synthase homeologous genes make sweet basil all green
Visual system hyperexcitability and compromised V1 receptive field properties in early-stage retinitis pigmentosa in mice
Mammary Tissue-Derived Extracellular Matrix Hydrogels Reveal the Role of the Irradiated Microenvironment in Breast Cancer Recurrence
Engineered Riboswitch Nano-carriers as a Possible Disease-Modifying Treatment for Metabolic Disorders
Information integration for nutritional decision-making in desert locusts
Detailed investigation on the role of lipid metabolizing enzymes in the pathogenesis of retinopathy of prematurity among preterm infants.
Knockouts of positive and negative elements of the circadian clock disrupt photoperiodic diapause induction in the silkworm, Bombyx mori
Does sexual conflict contribute to the evolution of novel warning patterns?
Developing a predictive model for an emerging epidemic on cassava in sub-Saharan Africa
Sex differences in coronary artery disease and diabetes revealed by scRNA-Seq and CITE-Seq of human CD4+ T cells
cGAS/STING-DEPENDENT SENSING OF ENDOGENOUS RNA
Quantifying rhythmicity in perceptual reports
From recency to the central tendency bias in working memory: a unifying attractor network model
Channel-independent function of UNC-9/INX in spatial arrangement of GABAergic synapses in C. elegans
The time course of categorical and perceptual similarity effects in visual search
Decoding Individual Differences in Mental Information from Human Brain Response Predicted by Convolutional Neural Networks
Coexistence of Cue-specific and Cue-independent Spatial Representations for Landmarks and Self-motion Cues in Human Retrosplenial Cortex
The history and organization of the Workshop on Population and Speciation Genomics
Plyometric training enhances strength and precision of the finger movements in pianists
A key role of the WEE1-CDK1 axis in mediating TKI-therapy resistance in FLT3-ITD positive acute myeloid leukemia patients
3D-surface reconstruction of cellular cryo-soft X-ray microscopy tomograms using semi-supervised deep learning
JBrowse Jupyter: A Python interface to JBrowse 2
Comprehensive machine-learning survival framework develop a consensus model in large scale multi-center cohorts for pancreatic cancer
The Limits of Molecular Signatures for Pancreatic Ductal Adenocarcinoma Subtyping
Ants act as olfactory bio-detectors of tumour in patient-derived xenograft mice
Improved SpCas9 and LbCas12a genome editing systems in Brassica oleracea and Brassica napus
Combined reference-free and multi-reference approaches uncover cryptic variation underlying rapid adaptation in microbial pathogens
nnSVG: scalable identification of spatially variable genes using nearest-neighbor Gaussian processes
Genome-wide data from medieval German Jews show that the Ashkenazi founder event pre-dated the 14th century
Genomic and bioclimatic diversity of Ethiopian barley (Hordeum vulgare L.) landraces reveals vulnerability to climate change
Multiplexed chromatin imaging reveals predominantly pairwise long-range coordination between Drosophila Polycomb genes
The origin and evolution of mitochondrial tropism in Midichloria bacteria
Insertions and deletions mediated functional divergence of Rossmann fold enzymes
Area of Habitat maps for the world's terrestrial birds and mammals
Foxe1 orchestrates thyroid and lung cell lineage divergence in mouse stem cell-derived organoids
Composition can buffer protein dynamics within liquid-like condensates.
Parallel clonal and molecular profiling of hematopoietic stem cells using RNA barcoding
In vitro and in vivo gene introduction in the cloudy catshark (Scyliorhinus torazame), a cartilaginous fish
Terminal differentiation and persistence of effector regulatory T cells essential for the prevention of intestinal inflammation
Neuroinflammation in neuronopathic Gaucher disease: Role of microglia and NK cells
Sensorimotor decisions rely on the entanglement of evidence and motor accumulation processes
Integration of sound and locomotion information by auditory cortical neuronal ensembles
Identification of differentially expressed novel tau associated proteins in transgenic AD model of Drosophila - a proteomic and in silico Approach
Focal electrical stimulation on an alcohol disorder model using MRI-compatible chronic neural monopolar carbon fiber electrodes.
Peripheral sensory neuron CB2 cannabinoid receptors are necessary for both CB2-mediated antinociceptive efficacy and sparing of morphine tolerance in a mouse model of neuropathic pain
Shelf-Life Specific Moisture Variation In Chitosan Of Genus Fenneropenaeus Distributed Along Arabian Sea, India
Shedding Light on functional Near Infrared Spectroscopy and Open Science Practices
CITE-Viz: Replicating the Interactive Flow Cytometry Workflow in CITE-Seq
Recalibrating the cerebellum DNA methylation clock: implications for ageing rates comparison
Ultrastructure Expansion Microscopy reveals the nanoscale cellular architecture of budding and fission yeast
No evidence for detectable direct effects of magnetic field on cellular autofluorescence
Novel synergistic combinations of last-line antibiotics and FDA-approved drugs against Klebsiella pneumoniae revealed by in vitro synergy screenings
Unique gut microbiome signatures among adult patients with moderate to severe atopic dermatitis in southern Chinese
Modification-Dependent Restriction Endonuclease-based sequencing method (EcoWI-seq) maps the genome-wide landscape of phosphorothioate modification at base resolution.
Sterol side chain alkylation by sponge and bacterial methyltransferases
Design and construction of 3D-printed devices to investigate active and passive bacterial dispersal on hydrated surfaces
Allosteric inactivation of an engineered optogenetic GTPase
On the interplay between lipids and asymmetric dynamics of an NBS degenerate ABC transporter
Juxtaposition of Bub1 and Cdc20 on phosphorylated Mad1 during catalytic mitotic checkpoint complex assembly
A SCID mouse model to evaluate the efficacy of antivirals against SARS-CoV-2 infection
Single molecule analyses of Salmonella translocated effector proteins reveal targeting to and dynamics in host cell endomembranes
A live attenuated vaccine confers superior mucosal and systemic immunity to SARS-CoV-2 variants
AI-based search for convergently expanding, advantageous mutations in SARS-CoV-2 by focusing on oligonucleotide frequencies
SARS-CoV-2 Omicron Variant Wave in India: Advent, Phylogeny and Evolution
The L1 Cell Adhesion Molecule Constrains Dendritic Spine Density through Ankyrin Binding in Pyramidal Neurons of the Mouse Cerebral Cortex
Gray Matter Volumetric Correlates of Attention Deficit and Hyperactivity Traits in Emerging Adolescents
Expanding EMC Foldopathies: Topogenesis Deficits Alter the Neural Crest
Infection of the maternal-fetal interface and vertical transmission following low-dose inoculation of pregnant rhesus macaques (Macaca mulatta) with an African-lineage Zika virus
Insights into plastic biodegradation: community composition and functional capabilities of the superworm (Zophobas morio) microbiome in styrofoam feeding trials
The spatiotemporal dynamics of recognition memory for complex versus simple auditory sequences
Optimal balancing of xylem efficiency and safety explains plant vulnerability to drought
Mannose metabolism inhibition sensitizes acute myeloid leukemia cells to cytarabine and FLT3 inhibitor therapy by modulating fatty acid metabolism to drive ferroptotic cell death.
Dynamic allostery in substrate binding by human thymidylate synthase
Feature Importance Network reveals novel functional relationships between biological features in Arabidopsis thaliana
A systematic evaluation of deep learning methods for the prediction of drug synergy in cancer
Adaptive diversification and niche packing on rugged fitness landscapes
Genomic insights into the adaptive and convergent evolution of Leuciscus waleckii inhabiting extremely alkaline environments
Cheaters among pollinators: Floral traits drive spatiotemporal variation in nectar robbing and thieving in Afrotropical rainforests
Rare Gli1+ perivascular fibroblasts promote skin wound repair
Adult Hox gene expression promotes periosteal stem cell maintenance and mediates reprogramming in a regionally restricted manner
The Vibrio cholerae Seventh Pandemic islands act in tandem to defend against a circulating phage
A Unified Catalog of 19,251 Non-human Reference Species Genomes Provides New Insights into the Mammalian Gut Microbiomes
Adaptive Immune Landscape of T-Cell Mediated Rejection of Human Kidney Allografts
Pathway and directional specificity of Hebbian plasticity induction in the cortical visual motion processing network
Altered Regulation of Ia Afferent Input during Voluntary Activity after Human Spinal Cord Injury
Trimethylamine N-oxide reduces neurite density and plaque intensity in a murine model of Alzheimer disease
Interneurons of fan-shaped body promote arousal in Drosophila
Arbuscular mycorrhizae reduce stress-induced plasticity of plant functional traits. A meta-analysis study
Oversharing by honey bees and the spread of viruses
Studying protein-protein interaction through side-chain modeling method OPUS-Mut
In vitro generation of human embryonic stem cell-derived heart organoids possessing physiological ion currents
Structural insights into bacterial sterol transport
Predicting the HER2 status in esophageal cancer from tissue microarrays using convolutional neural networks
Pairwise sequence similarity mapping with PaSiMap: reclassification of immunoglobulin domains from titin as case study
A potential Toxoplasma gondii lipoxygenase is necessary for virulence and associated with the host immune response
Nlrc4 inflammasome is critical for host protection against flagellated Salmonella
High-and Low-Frequency Deep Brain Stimulation in the Subthalamic Nucleus differentially modulate Response Inhibition and Action Selection in Parkinson's Disease
In situ cryo-electron tomography reveals the asymmetric architecture of mammalian sperm axonemes
Stable population structure in Europe since the Iron Age, despite high mobility
Linked selection and the evolution of altruism in a family-structured population
Evidence of divergent selection in a parasite due to its host immunological respond
Locus c{oelig}ruleus noradrenergic neurons phase-lock to prefrontal cortical and hippocampal infra-slow rhythms which synchronize with behavioral events
Morphogen gradient orchestrates pattern-preserving tissue morphogenesis via motility-driven (un)jamming
Differential effect of Fas activation on spinal muscular atrophy motoneuron death and induction of axonal growth
De Novo RNA Tertiary Structure Prediction at Atomic Resolution Using Geometric Potentials from Deep Learning
MultiCens: Multilayer network centrality measures to uncover molecular mediators of tissue-tissue communication
Hecatomb: An End-to-End Research Platform for Viral Metagenomics
On the bacterial ancestry of mitochondria: new insights with triangulated approaches
Population genomics of a threespine stickleback tapeworm in Vancouver Island
Local adaptation and host specificity to copepod intermediate hosts by the Schistocephalus solidus tapeworm
Late Fetal and Newborn Granulopoiesis but not Active Renin is Increased by Maternal Captopril Treatment During Perinatal Kidney Development
Site-specific decreases in DNA methylation in replicating cells following exposure to oxidative stress
The Individualized Neural Tuning Model: Precise and generalizable cartography of functional architecture in individual brains
Onsager regression characterizes living systems in passive measurements
Concurrent spinal and brain imaging with optically pumped magnetometers
DNA binding domain undergoes dynamic and selective protein-protein interactions to facilitate CTCF insulation
MHC-II molecules present RhoC-derived peptides on the surface of tumour cells
Alignment of Single-Molecule Sequencing Reads by Enhancing the Accuracy and Efficiency of Locality-Sensitive Hashing
Evolution of personality and locomotory performance traits during a late Pleistocene island colonization in a treefrog
PAX4 loss of function alters human endocrine cell development and influences diabetes risk
Recapitulation of the embryonic transcriptional program in insect pupae
The proto-oncogene DEK regulates neuronal excitability and tau accumulation in Alzheimer's disease vulnerable neurons
Photoperiod and vernalization alleles and their combinations greatly affected phenological and agronomic traits in bread wheat under autumn and spring sowing conditions
Chromatin-modifying enzymes as modulators of nuclear size during lineage differentiation
Pan-cancer scale screening reveals NRF2 associated immunoevasive characteristics in non-small cell lung cancer and squamous malignancies
High-content cellular screen image analysis benchmark study
Open Access Repository-Scale Propagated Nearest Neighbor Suspect Spectral Library for Untargeted Metabolomics
Multifunctional flexible electro-optical arrays for simultaneous spatiotemporal cardiac mapping and modulation
Hepatic AMPK activation in response to dynamic REDOX balance is a biomarker of exercise to improve blood glucose control
Senolytic Treatment Reduces Cell Senescence and Necroptosis in Sod1 Knockout Mice that is Associated with Reduced Inflammation and Hepatocellular Carcinoma
The Drosophila attP40 docking site and derivatives are insertion mutations of MSP300
Novel epidemiological model of gastrointestinal-nematode infection to assess grazing cattle resilience by integrating host growth, parasite, grass and environmental dynamics
Remote sensing tools for plant invasions assessment in native tropical forests of a volcanic island
Detection of Borrelia garinii in the USA
Melanogenic Activity Facilitates plasmacytoid Dendritic Cell Maturation
The canonical HPA axis contributes to locomotion during photoadaptation but is not required
Category representations in the primary visual cortex support orientation discrimination
Disrupted Decision-Making: EcoHIV Inoculation Following a History of Cocaine Use
Identifying the Neural Correlates of Balance Deficits in Traumatic Brain Injury using the Partial Least Squares Correlation (PLSC) analysis
Generating parallel representations of position and identity in the olfactory system
Negative emotional behavior during fentanyl abstinence is mediated by adaptations in nucleus accumbens neuron subtypes
A machine learning approach for automatic sleep staging using heart rate variability
An algorithmic framework for isoform-specific functional analysis
PleistoDist: A toolbox for visualising and quantifying the effects of Pleistocene sea-level change on island archipelagos
Identification of representative trees in random forests based on a new tree-based distance measure
Integration of gene expression data in Bayesian association analysis of rare variants
Topological analysis of brain dynamics in autism based on graph and persistent homology
Intermittent fasting mitigates cognitive deficits in Alzheimer's disease via the gut-brain axis
The lncRNA Firre functions as a transcriptional activator from a distance
Environmental selection, rather than neutral processes, best explain patterns of diversity in a tropical rainforest fish
The nerodevelopmental genes alan shepard and Neuroglian are spatially structured in an admixed population and contribute to female mate preference
Ecological Drivers of Community Cohesion
Generation of a human ovarian granulosa cell model from induced pluripotent stem cells
Active licking shapes cortical taste coding.
Prediction of Stroke Outcome in Mice Based on Non-Invasive MRI and Behavioral Testing
#PeerReview from @eLife of ???????? Nanoscale resolution of microbial fiber degradation in action
Identification by cryoEM of a densovirus causing mass mortality in mass-reared larval darkling beetles (Zophobas morio)
#PeerReview from @eLife of ???????? A dual-target herbicidal inhibitor of lysine biosynthesis
#PeerReview from @eLife of ???????? GENESPACE: syntenic pan-genome annotations for eukaryotes
#PeerReview from @BiophysicsColab of ???????? Combinatorial G x G x E CRISPR screening and functional analysis highlights SLC25A39 in mitochondrial GSH transport
Structural-guided fragment-based drug discovery applied to antitoxin, MAB3862 opens a new possibility of exploring the Toxin and Antitoxin for antibiotics.
The ClpP Peptidase Forcefully Grips Protein Substrates
Solubility-aware protein binding peptide design using AlphaFold
Cysteine Restriction-Specific Effects of Sulfur Amino Acid Restriction on Lipid Metabolism
Activity-based CRISPR Scanning Uncovers Allostery in DNA Methylation Maintenance Machinery
Protein painting reveals pervasive remodeling of conserved proteostasis machinery in response to pharmacological stimuli.
Diverse RNA viruses associated with diatom, eustigmatophyte, dinoflagellate and rhodophyte microalgae cultures
More accurate estimation of cell composition in bulk expression through robust integration of single-cell information
Human REM sleep controls neural excitability in support of memory formation
Genes ruler for genomes, Gnodes, measures assembly accuracy in animals and plants
Quantifying the adaptive landscape of commensal gut bacteria using high-resolution lineage tracking
Evolution of reading and face circuits during the first three years of reading acquisition
Medial temporal lobe structure, mnemonic and perceptual discrimination in healthy older adults and those at risk for mild cognitive impairment
Flexing the principal gradient of the cerebral cortex to suit changing semantic task demands
Wild-type IDH1 inhibition enhances chemotherapy response in melanoma
NMR as a readout to monitor and restore the integrity of complex chemoenzymatic reactions
Bioengineering multifunctional extracellular vesicles for targeted delivery of biologics to T cells
Time series transcriptome analysis uncovers regulatory networks and a role for the circadian clock in the Drosophila melanogaster female's response to Sex Peptide
Endoplasmic Reticulum membranes are continuously required to maintain mitotic spindle size and forces
Picking winners in cell-cell collisions: wetting, speed, and contact
The Scar/WAVE complex drives normal actin protrusions without the Arp2/3 complex, but proline-rich domains are required
Intrinsic RNA targeting constrains the utility of CRISPR-Cas13 systems
Detecting apoptosis via DODO
First report of classical knockdown resistance (kdr) mutation, L1014F, in human head louse Pediculus humanus capitis (Phthiraptera: Anoplura)
An atrial fibrillation-associated regulatory region modulates cardiac Tbx5 levels and arrhythmia susceptibility
A toxin-mediated policing system in Bacillus improves population fitness via penalizing non-cooperating phenotypic cheaters
Adding a new dimension: Multi-level structure and organization of mixed-species Pseudomonas aeruginosa and Staphylococcus aureus biofilms in a 4-D wound microenvironment
Melanocyte-secreted Fibromodulin constrains skin inflammation in mice injected with lupus serum
The Influences of Stomatal Size and Density on Rice Drought, Salinity and VPD Resilience
KDM4A promotes NEPC progression through regulation of MYC expression
Exogenous DNA upregulates DUOX2 expression and function in human pancreatic cancer cells by activating the cGAS-STING signaling pathway
Conformational fluctuations in molten globule state of α-lactalbumin
Hydroxylation site-specific and production-dependent roles of endogenous oxysterols in cellular cholesterol homeostasis
pH-responsive self-assembled compartments as tuneable model protocellular membrane systems
Transnational non-invasive monitoring and spatial capture-recapture models reveal strong effects of humans on connectivity for the Pyrenean brown bear
Site pleiotropy of a stickleback tooth and fin enhancer
TGFβ treatment alters the scleral fibroblast migratory response to cyclic strain in an ERK-dependent manner
Surface-Induced cAMP Signaling Requires Multiple Features of the Pseudomonas aeruginosa Type IV Pili
Parvimonas micra, an oral pathobiont associated with colorectal cancer, epigenetically reprograms human primary intestinal epithelial cells
Regulation of Chlamydia RsbU phosphatase activity by the enolase product, phosphoenolpyruvate
tRNA Methylation Resolves Codon Usage Bias at the Limit of Cell Viability
Nanoparticle-induced augmentation of neutrophils' phagocytosis of bacteria
Distinct population and single-neuron selectivity for executive and episodic processing in human dorsal posterior cingulate
Status epilepticus induces chronic silencing of burster and dominance of regular firing neurons during sharp wave-ripples in the mouse subiculum
Doublecortin-like kinase 1 (DCLK1) Facilitates Dendritic Spine Growth of Pyramidal Neurons in Mouse Prefrontal Cortex
Asymmetric Signaling Across the Hierarchy of Cytoarchitecture within the Human Connectome
Kidney collecting duct cells make vasopressin in response to NaCl induced hypertonicity
Modelling the structure of Short Gastrulation and generation of a toolkit for studying its function in Drosophila
Synonymous codon usage regulates translation initiation
Monozygotic twins discordant for schizophrenia differ in maturation and synaptic transmission
A gain-of-function recurrent missense variant leads to a GABAergic/glutamatergic imbalance in a forebrain organoid model of PACS1 syndrome
The 5-LOX/COX-2 cross-over metabolite, hemiketal E2, enhances VEGFR2 activation and promotes angiogenesis
MYC Overexpression Drives Immune Evasion in Human Cancer that is Reversible Through Restoration of Pro-Inflammatory Macrophages
Accurate Identification of Extrachromosomal Circular DNA from Long-read Sequences.
Polycomb proteins translate histone methylation to chromatin folding
Miro GTPase domains regulate assembly of the mitochondrial motor-adaptor complex
Moderate ART resistance mutations with low fitness cost in malaria parasites from Africa
CvkR, a novel MerR-type transcriptional regulator, is a repressor of class 2 type V-K CRISPR-associated transposase systems
Reversal of splicing infidelity is a pre-activation step in B cell differentiation
Borrelia burgdorferi engages mammalian type I interferon responses via the cGAS-STING pathway
Blockade of TGF-β signaling reactivates HIV-1/SIV reservoirs and immune responses in vivo
Arabidopsis thaliana rosette growth habit is a photomorphogenic trait controlled by the TALE homeodomain protein ATH1 and involves TOR kinase
Identification of Fusarium Head Blight resistance in Triticum timopheevii accessions and characterisation of wheat-T. timopheevii introgression lines for enhanced resistance.
Female factors are important for the seminal Sex Peptide's association with sperm in mated female D. melanogaster.
Structural Basis of Mutation-Dependent p53 Tetramerization Deficiency
Single-cell characterisation of the hematopoietic bone marrow interactome in health and disease
An atlas of epithelial cell states and plasticity in lung adenocarcinoma
C-terminal determinants for RNA binding motif 7 protein stability and RNA recognition
Structural basis of Yta7 ATPase-mediated nucleosome disassembly
Arf GTPase activates the WAVE Regulatory Complex through a novel binding site
#PeerReview from @eLife of ???????? Collective dynamics support group drumming, reduce variability, and stabilize tempo drift
#PeerReview from @eLife of ???????? Gene Expression and Tracer-Based Metabolic Flux Analysis Reveals Tissue-Specific Metabolic Scaling in vitro, ex vivo, and in vivo
#PeerReview from @eLife of ???????? A generalized cortical activity pattern at internally-generated mental context boundaries during unguided narrative recall
#PeerReview from @eLife of ???????? SRSF10 is essential for progenitor spermatogonia expansion by regulating alternative splicing
#PeerReview from @eLife of ???????? DIP2 is a unique regulator of diacylglycerol lipid homeostasis in eukaryotes
#PeerReview from @eLife of ???????? A single exposure to altered auditory feedback causes observable sensorimotor adaptation in speech 2021-07-26
#PeerReview from @eLife of ???????? Altered excitatory and inhibitory neuronal subpopulation parameters are distinctly associated with tau and amyloid in Alzheimer's disease
Predictive Models of Genome-wide Aryl Hydrocarbon Receptor DNA Binding Reveal Tissue Specific Binding Determinants
VAP-A intrinsically disordered regions enable versatile tethering at membrane contact sites
Vitamin K-dependent carboxylation of junctate regulates calcium flux and adaptation to metabolic stress in β-cells
Porous marine snow differentially benefits chemotactic, motile, and non-motile bacteria
Development of 3D bovine intestinal organoid derived models to investigate Mycobacterium avium ssp paratuberculosis pathogenesis
Agency as a Bridge to Form Associative Memories
High-resolution kinetic gene expression analysis of T helper cell differentiation reveals a STAT-dependent, unique transcriptional program in Th1/2 hybrid cells
Changes of oscillatory and aperiodic neuronal activity in working memory following anaesthesia: a prospective observational study
Interpretable machine learning of action potential duration restitution kinetics in single-cell models of atrial cardiomyocytes
Selective observation of semi-rigid residues on the surface of dynamically complex mutant huntingtin protein fibrils
Modelling human and non-human animal network data in R using STRAND
Analysis of the contribution of intrinsic disorder in shaping potyvirus genetic diversity
Mycorrhizas shape the evolution of plant adaptation to drought
Blind spots on western blots: a meta-research study highlighting opportunities to improve figures and methods reporting
Short term tomato consumption alters the pig gut microbiome towards a more favorable profile
Structural insights for neutralization of BA.1 and BA.2 Omicron variants by a broadly neutralizing SARS-CoV-2 antibody
Post-transcriptional regulatory feedback encodes JAK-STAT signal memory of interferon stimulation
Efficient parameter calibration and real-time simulation of large scale spiking neural networks with GeNN and NEST
Comparative Transcriptome Analysis of Hypocotyls During the Developmental Transition of C3 cotyledons to C4 Leaves in Halimocnemis mollissima: Exploring Root-Shoot Signalings Involved in the Establishing of C4 traits
Single Particle Tracking With Compressive Sensing Using Progressive Refinement Method On Sparse Recovery (spt-PRIS)
The Smc5/6 complex is a DNA loop extruding motor
Dendrite branching receptor HPO-30 uses two novel mechanisms to regulate actin cytoskeletal remodeling
PROPOSE: Predictive and robust probe selection for spatial transcriptomics
In silico screening of novel senolytic compounds from natural food sources
Improved methods for the large-scale cultivation of Giardia lamblia trophozoites in the academic laboratory
Identification of two pyruvate transporters in Salmonella enterica serovar Typhimurium and their biological relevance
Antibiotic acyldepsipeptides stimulate the Streptomyces Clp-ATPase/ClpP complex for accelerated proteolysis
The Human Dendritic Cell Atlas: An integrated transcriptional tool to study human dendritic cell biology
Humoral immunity to SARS-CoV-2 elicited by combination COVID-19 vaccination regimens
Three-doses of BNT162b2 COVID-19 mRNA vaccine establishes long-lasting CD8+ T cell immunity in CLL and MDS patients
Astrocytic Gi-GPCR activation enhances stimulus-evoked extracellular glutamate
Transretinal migration of astrocytes and brain/spinal cord-like cells arising from transplanted human retinal organoids.
Evidence for a common mechanism supporting invigoration of action selection and action execution
Microglial P2X4 receptors promote ApoE degradation and cognitive deficits in Alzheimer disease
A critical role for spike synchrony in determining steep 1/f slopes in the setting of bursting EEG patterns
Flexible perceptual encoding by discrete gamma events
An Updated Gene Regulatory Network reconstruction of multidrug-resistant Pseudomonas aeruginosa CCBH4851
Signal peptide efficiency: from high-throughput data to prediction and explanation
The cluster transfer function of AtNEET supports the ferredoxin-thioredoxin network of plant cells
No circadian clock-gene circuit in the generation of cellular bioluminescence rhythm of CaMV35S::PtRLUC in duckweed
Arabidopsis cell suspension culture that lacks circadian rhythms can be recovered by constitutive ELF3 expression
Trans-generational physiological condition of embryos is conditioned by maternal thermal stress in Octopus maya
Hypoxic memory of tumor intrinsic type I interferon suppression promotes breast cancer metastasis
Development of an antibody panel for imaging mass cytometry to investigate cancer-associated fibroblast heterogeneity and spatial distribution in archival tissues
VPS9D1-AS1 overexpression amplifies intratumoral TGF-β signaling and promotes tumor cell escape from CD8+ T cell killing in colorectal cancer
Cell-free Tumor Methylome Analysis of Small Cell Lung Cancer Patients Identifies Subgroups with Prognostic Associations
Polo-like kinase-1 Inhibitors and the Antiandrogen Abiraterone Synergistically Disrupt Mitosis and Kill Cancer Cells of Disparate Origin Independently of Androgen Receptor Signaling
Development and utility of a PAK1-selective degrader
Reversal of lactate and PD-1-mediated macrophage immunosuppression controls growth of PTEN/p53-deficient prostate cancer
ABL1 Kinase plays an important role in spontaneous and chemotherapy-induced genomic instability in multiple myeloma
MAP Kinase and mammalian target of rapamycin are main pathways of gallbladder carcinogenesis: Results from bioinformatic analysis of Next Generation Sequencing data from a hospital-based cohort.
Absorption changes in Photosystem II in the Soret band region upon the formation of the chlorophyll cation radical [PD1PD2]+
Chimera States among Synchronous Fireflies
LAWS: Local Alignment for Water Sites -- tracking ordered water in simulations
Diffraction contrast in cryo-scanning transmission electron tomography reveals the boundary of hemozoin crystals in situ
Optimising Elastic Network Models for Protein Dynamics and Allostery: Spatial and Modal Cut-offs and Backbone Stiffness
Echolocation-like model of directed cell migrationwithin growing tissues
In situ architecture and membrane fusion of SARS-CoV-2 Delta variant
petiteFinder: An automated computer vision tool to compute Petite colony frequencies in baker's yeast
Identification of a gene signature to assess HSF1 transcriptional activity
N-ACT: An Interpretable Deep Learning Model for Automatic Cell Type and Salient Gene Identification
Comprehensive Analysis of the Expression and Prognosis for PSMBs in Clear Cell Renal Cell Carcinoma
SPACE-GM: geometric deep learning of disease-associated microenvironments from multiplex spatial protein profiles.
Tracking single cell evolution via clock-like chromatin accessibility
SCONCE2: jointly inferring single cell copy number profiles and tumor evolutionary distances
DNAscan2: a versatile, scalable, and user-friendly analysis pipeline for next-generation sequencing data
Systematic functional annotation workflow for insects
Using methylation data to improve transcription factor binding prediction
DirectMS1Quant: ultrafast quantitative proteomics with MS/MS-free mass spectrometry
neoMS: Attention-based Prediction of MHC-I Epitope Presentation
Antisense pairing and SNORD13 structure guide RNA cytidine acetylation
Species identification of early colonial bone artefacts excavated from Pyrmont, Australia, by mass spectrometric identification of collagen peptides
Conformational changes in mitochondrial complex I from the thermophilic eukaryote Chaetomium thermophilum
Translational Activity Controls Ribophagic Flux and Turnover of Distinct Ribosome Pools
Mouse primary T cell phosphotyrosine proteomics enabled by BOOST
Transcriptome analysis in the silkworm Bombyx mori overexpressing piRNA-resistant Masculinizer gene
A survey of lineage-specific genes in Triticeae reveals de novo gene evolution from genomic raw material
Accounting for intraspecific variation in continuous trait evolution on a reticulate phylogeny
Ancient DNA from the extinct New Zealand grayling (Prototroctes oxyrhynchus) reveals evidence for Miocene marine dispersal
Insights into the genomics of clownfish adaptive radiation: the genomic substrate of the diversification
Climatic niche evolution of infectious diseases driving amphibian declines
The limits to ecological limits to diversification
Low spontaneous mutation rate in a complex multicellular eukaryote with a haploid-diploid life cycle
Systemic pesticides in a solitary bee pollen food store affect larval development and increase pupal mortality
Modelling spatially autocorrelated detection probabilities in spatial capture-recapture using random effects
Modeling ecological communities when composition is manipulated experimentally
The wild life of ticks: using passive surveillance to determine the distribution and wildlife host range of ticks and the exotic Haemaphysalis longicornis, 2010-2021
Simulating alternative forest management in a changing climate on a Pinus nigra subsp. laricio plantation in Southern Italy
Heme-deficient metabolism and impaired cellular differentiation as an evolutionary trade-off for human infectivity in Trypanosoma brucei gambiense
The H3K27me3 epigenetic mark is crucial for callus cell identity and for the acquisition of new fate during root and shoot regeneration
Differential integration of activation and repression signals in a multi-enhancer system
Centrosome Loss And Cell Proliferation Defects Underlie Developmental Failure In Haploid Zebrafish Larvae
Replication stress tolerance and management differs between naive and primed pluripotent cells
Dandy Walker-like malformations in mutant mice demonstrate a role for PDGF-C/PDGFRα signalling in cerebellar development
Computationally efficient mechanism discovery for cell invasion with uncertainty quantification
Differential modifications of the C-terminal tails of α-tubulin isoforms and their in vivo importance for kinesin function in Drosophila
Assessment of Human Renal Transporter Based Drug-Drug Interactions Using Proximal Tubule Kidney-Chip
Fat body-specific reduction of CTPS alleviates HFD-induced obesity
Mesenchymal Stromal Cells Donate Mitochondria to Articular Chondrocytes Exposed to Mitochondrial, Environmental, and Mechanical Stress
Galectin-9 interacts with Vamp-3 to regulate cytokine secretion in dendritic cells
Perturbation of ATP6V0A1 as a Driver and Druggable Target for Renal Proximal Tubular Cellular Injury in Nephropathic Cystinosis
Aberrant association of chromatin with nuclear periphery induced by Rif1 leads to mitotic defect and cell death.
Longitudinal comparison of the developing gut virome in infants and their mothers
Application and comparison of lyophilisation protocols to enhance stable long-term storage of filovirus pseudotypes for use in antibody neutralisation tests
The targeted deletion of genes responsible for expression of the Mth60 fimbriae leads to loss of cell-cell connections in M. thermautotrophicus ΔH
Development and Evaluation of a Colloidal Gold Immunofiltration Assay for Penside Diagnosis of Visceral Schistosomosis in Cattle
Neuro-immune Crosstalk in the Enteric Nervous System from Early Postnatal Development to Adulthood
Profile of Mycobacterium tuberculosis-specific CD4 T cells at the site of disease and blood in pericardial tuberculosis
A Multimodal Neuroimaging Dataset to Study Spatiotemporal Dynamics of Visual Processing in Humans
Macroscale Thalamic Functional Organization Disturbances And Underlying Core Cytoarchitecture In Early-Onset Schizophrenia
#PeerReview from @ReviewCommons of ???????? Fat Body Phospholipid State Dictates Hunger Driven Feeding Behavior
#PeerReview from @BiophysicsColab of ???????? Structural basis of ion - substrate coupling in the Na+-dependent dicarboxylate transporter VcINDY
#PeerReview from @ReviewCommons of ???????? Reorganization of F-actin nanostructures is required for the late phases of SARS-CoV-2 replication in pulmonary cells.
#PeerReview from @PeerCommunityIn of ???????? Riparian forest restoration as sources of biodiversity and ecosystem functions in anthropogenic landscapes
#PeerReview from @ReviewCommons of ???????? Transient regulation of focal adhesion via Tensin3 is required for nascent oligodendrocyte differentiation
Genome-wide selection inference at short tandem repeats
Tissue and cell-type specific molecular and functional signatures of 16p11.2 reciprocal genomic disorder across mouse brain and human neuronal models
Adult-born granule cells improve stimulus encoding and discrimination in the dentate gyrus
Modality specific roles for metabotropic GABAergic signaling and calcium induced calcium release mechanisms in regulating cold nociception
The length of the thalamo-cortical white matter fibers brings insight into sex differences in sleep spindle frequency
Increased sensorimotor structural connectivity in high schizotypy
Cerebellar motor memory expression requires learned alterations to the activity of inhibitory molecular layer interneurons
Foxd1 dependent induction of temporal retinal character is required for visual function
#PeerReview from @ReviewCommons of ???????? Continuous sensing of IFNα by hepatic endothelial cells shapes a vascular antimetastatic barrier
#PeerReview from @ASAPbio_ of ???????? Microtubule rescue at midzone edges promotes overlap stability and prevents spindle collapse during anaphase B
Deep learning-based approach for the characterization and quantification of histopathology in mouse models of colitis
Aspects of the glycome of endochondral ossification
Contrasting reproductive strategies despite convergent traits for two dryland river-floodplain species
Evaluating Stored Platelet Shape Change Using Imaging Flow Cytometry
Structure and mechanism of LARGE1 matriglycan polymerase
Stromal Hippo-YAP signaling in stem cell niche controls intestinal homeostasis
Ena/VASP clustering at microspike tips involves Lamellipodin but not I-BAR proteins, and absolutely requires unconventional Myosin-X
Proximity labelling identifies pro-migratory endocytic recycling cargo and machinery of the Rab4 and Rab11 families
Induced pluripotent stem cells and cerebral organoids from the critically endangered Sumatran rhinoceros
Drosophila melanogaster is a powerful host model to study mycobacterial virulence
Insulin-like Growth Factor-1 Synergizes with IL-2 to Induce Homeostatic Proliferation of Regulatory T cells
Cell-autonomous immune dysfunction driven by disrupted autophagy in C9orf72-ALS iPSC-derived microglia contributes to neurodegeneration
LDL1 and LDL2 histone demethylases interact with FVE to regulate flowering in Arabidopsis
RNA Methylome Reveals the m6A-Mediated Regulation of Flavor Metabolites in Tea Leaves under Solar-Withering
#PeerReview from @eLife of ???????? Systematic lncRNA mapping to genome-wide co-essential pathways uncovers cancer dependency on uncharacterized lncRNAs
#PeerReview from @eLife of ???????? WhyD tailors surface polymers to prevent bacteriolysis and direct cell elongation in Streptococcus pneumoniae
#PeerReview from @eLife of ???????? Quantitative MRI reveals differences in striatal myelin in children with DLD
#PeerReview from @eLife of ???????? The role of surface adhesion on the macroscopic wrinkling of biofilms
#PeerReview from @eLife of ???????? Spontaneous Neuronal Oscillations in the Human Insula are Hierarchically Organized Traveling Waves
#PeerReview from @eLife of ???????? Gill developmental program in the teleost mandibular arch
Uncovering the mechanism for aggregation in repeat expanded RNA reveals a reentrant transition
Structural basis underlying specific biochemical activities of non-muscle tropomyosin isoforms
Biophysical and functional characterization of K+-Cl- co-transporters from Drosophila melanogaster and Hydra vulgaris
Evaluation of metagenomic, 16S rRNA gene and ultra-plexed PCR-based sequencing approaches for profiling antimicrobial resistance gene and bacterial taxonomic composition of polymicrobial samples
Complexities of recapitulating polygenic effects in natural populations: replication of genetic effects on wing shape in artificially selected and wild caught populations of Drosophila melanogaster.
Turning coldspots into hotspots: targeted recruitment of axis protein Hop1 stimulates meiotic recombination in Saccharomyces cerevisiae
Strongly truncated Dnaaf4 plays a conserved role in Drosophila ciliary dynein assembly as part of an R2TP-like co-chaperone complex with Dnaaf6
Myofiber reconstruction at micron scale reveals longitudinal bands in heart ventricular walls
Fob1-dependent condensin recruitment and loop extrusion on yeast chromosome III
Mapping the landscape of anti-phage defense mechanisms in the E. coli pangenome
Mapping the risk of Rift Valley fever in Uganda using national seroprevalence data from cattle, sheep and goats
Small-molecule inhibitors targeting prokaryotic ClpQ protease in Plasmodium display anti-malarial efficacies against blood and liver stages
Partner-assisted artificial selection of a secondary function for efficient bioremediation
Delineating the transcriptional landscape and clonal diversity of virus- specific CD4 + T cells during chronic viral infection
Proliferation is a driver of quorum sensing in an in vitro model of tissue resident macrophages
Characterization of full-length CNBP expanded alleles in myotonic dystrophy type 2 patients by Cas9-mediated enrichment and nanopore sequencing
A human and rhesus macaque interferon-stimulated gene screen reveals ARHGEF3/XPLN as an antiviral gene against hepatitis C virus and other flaviviruses
Delivery of Circular mRNA via Degradable Lipid Nanoparticles against SARS-COV-2 Delta Variant
The SARS-CoV-2 Spike Protein Activates the Epidermal Growth Factor Receptor-Mediated Signaling
Biochemical Characterization of Emerging SARS-CoV-2 Nsp15 Endoribonuclease Variants
Low immune response after 1.5 years of primary SARS-CoV-2 infection and Covishield vaccination lead to SARS-CoV-2 reinfection
A Mathematical Model of the Within-Host Kinetics of SARS-CoV-2 Neutralizing Antibodies Following COVID-19 Vaccination
A Bispecific Antibody Targeting RBD and S2 Potently Neutralizes SARS-CoV-2 Omicron and Other Variants of Concern
Effect on the conformations of spike protein of SARS-CoV-2 due to mutation
Contrasting patterns of genetic admixture explain the phylogeographic history of Iberian high mountain populations of midwife toads
Targeting Echinococcus multilocularis PIM kinase for improving anti-parasitic chemotherapy
Prenatal alcohol exposure alters axon formation and Robo/Slit guidance cue expression in the internal capsule at E15.5
Functional connectivity dynamics reflect disability and multi-domain clinical impairment in patients with relapsing-remitting multiple sclerosis
AtlasXbrowser enables spatial multi-omics data analysis through the precise determination of the region of interest
Beyond the Euclidean brain: inferring non-Euclidean latent trajectories from spike trains
Deep Learning on Multimodal Chemical and Whole Slide Imaging Data for Predicting Prostate Cancer Directly from Tissue Images
Paths to adaptation under fluctuating nitrogen starvation: The spectrum of adaptive mutations in Saccharomyces cerevisiae is shaped by transposons and microhomology-mediated recombination
The homodimeric structure of the LARGE1 dual glycosyltransferase
Simplified fecal community transplant restores Clostridioides difficile colonization resistance to antibiotic perturbed murine communities
IL-13-programmed airway tuft cells produce PGE2, which promotes CFTR-dependent mucociliary function
Mapping odorant sensitivities reveals a sparse but structured representation of olfactory chemical space by sensory input to the mouse olfactory bulb.
Serotonin coordinates reproductive functions in Caenorhabditis elegans
Quantification of astrocytic synaptic pruning in hippocampus in response to in vitro Aβ oligomer incubation via colocalization analysis with C1q
Voluntary and forced exposure to ethanol vapor produces similar escalation of alcohol drinking but differential recruitment of brain regions related to stress, habit, and reward in male rats.
Optogenetic rejuvenation of mitochondrial membrane potential extends C. elegans lifespan
Proteogenomic characterization of age and sex interactions in cardiac gene expression
Pytri: A multi-weight detection system for biological entities
Rapid modeling of experimental molecular kinetics with simple electronic circuits instead of with complex differential equations
Potent activation of NAD+-dependent deacetylase Sirt7 by nucleosome binding
Effects of temperature on mating behaviour and mating success: a meta-analysis
Geodesics to characterize the phylogenetic landscape
Nuclear Ribosomal Internal Transcribed Spacer 1 (ITS1) variation in Lady Bird Beetles (Coccinellidae)
Fermented foods restructure gut microbiota and promote immune regulation via microbial metabolites
MicroRNAs contribute to the host response to Coxiella burnetii
B cell receptor stimulation induces IgE plasma cell apoptosis
Genome-wide analysis of dendritic cell differentiation
Sleep does not influence schema-facilitated motor memory consolidation
Infestation and growth of Tribolium confusum (Coleoptera: Tenebrionidae) on two varieties of local durum wheat: nutritional value and varietal susceptibility
A label-free method to track individuals and lineages of budding cells
Parasites, infections and inoculation in synthetic minimal cells
High throughput peptidomics elucidates immunoregulatory functions of plant thimet oligopeptidase-directed proteostasis
RFcaller: a machine learning approach combined with read-level features to detect somatic mutations
Vast heterogeneity in cytoplasmic diffusion rates revealed by nanorheology and Doppelgänger simulations
All the ways your eyes can move if you don't look: Eyeball lifting, retraction and compression during blinks
Gateway Identity and Spatial Remapping in a Combined Grid and Place Cell Attractor.
Strategic exploration in the macaque prefrontal cortex
Tethering distinct molecular profiles of single cells by their lineage histories to investigate sources of cell state heterogeneity
HumanMine: advanced data searching, analysis and cross-species comparison.
#PeerReview from @eLife of ???????? Generation and timing of graded responses to morphogen gradients
Eudicot primary cell wall glucomannan is related in synthesis, structure and function to xyloglucan
#PeerReview from @eLife of ???????? The origin of universal cell shape variability in a confluent epithelial monolayer
#PeerReview from @eLife of ???????? Genetic barriers to gene flow separate divergent substitution rates across a butterfly hybrid zone
RAS and PP2A activities converge on epigenetic gene regulation
#PeerReview from @eLife of ???????? ECM-integrin signalling instructs cellular position-sensing to pattern the early mouse embryo
#PeerReview from @eLife of ???????? Widespread introgression across a phylogeny of 155 Drosophila genomes
#PeerReview from @eLife of ???????? Nigrostriatal Dopamine Signals Sequence-Specific Action-Outcome Prediction Errors
Accelerating the clock: Interconnected speedup of energetic and molecular dynamics during aging in cultured human cells
Tau seeds translocate across the cell membrane to initiate aggregation
Neural signals encoded by specific frequencies of closed-loop electrical stimulation structurally and functionally reconstruct spinal sensorimotor circuits after spinal cord injury
Selective auditory attention modulates cortical responses to sound location change for speech in quiet and in babble
Data-driven microscopy allows for automated targeted acquisition of relevant data with higher fidelity
Hippocampus Modulates Natural Sound Processing at Early Auditory Centers