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Anti-proliferative effect of potential LSD1/CoREST inhibitors based on molecular dynamics model for treatment of SH-SY5Y neuroblastoma cancer cell line |
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Sustainable elk harvests in Alberta with increasing predator populations |
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#PeerReview from @EMBOPress of ???????? Structural basis for feedforward control in the PINK1/parkin pathway |
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Further antibody escape by Omicron BA.4 and BA.5 from vaccine and BA.1 serum |
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Non-equilibrium protein folding and activation by ATP-driven chaperones |
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Intrinsically disordered interaction network in an RNA chaperone revealed by native mass spectrometry |
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Multiplexed microfluidic platform for stem-cell derived pancreatic islet β cells |
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Native size exclusion chromatography-based mass spectrometry (SEC-MS) identifies novel components of the Heat Shock Protein 90-dependent proteome |
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Rates and spectra of de novo structural mutation in Chlamydomonas reinhardtii |
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Greater alteration of gut microbiota occurs in childhood obesity than adulthood obesity |
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Cytochrome expression shifts in Geobacter sulfurreducens to maximize energy conservation in response to changes in redox conditions |
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Conservation of spatiotemporal DNA replication origin and terminus segregation patterns in Sinorhizobium meliloti with re-engineered bi- and monopartite genomes |
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Rapid, in-patient adaptations of Legionella pneumophila to the human host |
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Uncovering Lasonolide A biosynthesis using genome-resolved metagenomics |
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A cryptic transcription factor regulates Caulobacter adhesin development |
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Secreted filarial nematode galectins modulate host immune cells |
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Enhancing the anti-tumor efficacy of Bispecific T cell engagers via cell surface glycocalyx editing |
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The interface of condensates of the hnRNPA1 low complexity domain promotes formation of amyloid fibrils |
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Structural characterization of a breast cancer-associated mutation in caveolin-1 |
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Predictions of immunogenicity reveal potent SARS-CoV-2 CD8+ T-cell epitopes |
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Site-specific validation and quantification of RNA 2'-O-methylation by qPCR with RNase H |
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Limitations of qPCR to estimate DNA quantity: AnRFU method to facilitate inter-laboratory comparisonsfor activity level, and general applicability |
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Self-assembly and structure of a clathrin-independent AP-1:Arf1 tubular membrane coat |
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Derivation of the immortalized cell line-UM51-PrePodo-hTERT and its responsiveness to Angiotensin II and activation of RAAS |
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Artificially stimulating retrotransposon activity increases mortality and accelerates a subset of aging phenotypes in Drosophila |
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Using a reverse genetics system to generate recombinant SARS-CoV-2 expressing robust levels of reporter genes |
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Diversity, abundance, and host specificity of the human skin associated circular and single stranded DNA virome |
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Dynamic bimodality of curli expression in planktonic cultures of Escherichia coli is stabilized by cyclic-di-GMP regulation |
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A protocol for the use of cold plasma treatment to inhibit in vitro growth of Fusarium graminearum. |
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Anti-chemokine antibodies after SARS-CoV-2 infection correlate with favorable disease course |
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Intranasal pediatric parainfluenza virus-vectored SARS-CoV-2 vaccine candidate is protective in macaques |
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The SARS-CoV-2 spike protein binds and modulates estrogen receptors |
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Tissue-specific modifier alleles determine Mertk loss-of-function traits |
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Reduced Neutralization of SARS-CoV-2 Omicron Variant in Sera from SARS-CoV-1 Survivors after 3-dose of Vaccination |
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Modeling suggests that multiple immunizations or infections will reveal the benefits of updating SARS-CoV-2 vaccines |
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Single Nucleus RNA Sequencing of Human Pancreatic Islets In Vitro and In Vivo Identifies New Gene Sets and Three β-Cell Subpopulations with Different Transcriptional Profile |
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Glucocorticoid receptor activation during human microglial differentiation leads to genomic instability and senescence |
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Opsin-free optical neuromodulation and electrophysiology enabled by a soft monolithic infrared multifunctional neural interface |
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Unbiased proteomic and forward genetic screens reveal that mechanosensitive ion channel MSL10 functions at ER-plasma membrane contact sites in Arabidopsis thaliana |
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Time-efficient relaxation measurements by 31P MR fingerprinting in human brain at 7T |
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A Well-Characterized Polycistronic-Like Gene Expression System in Yeast |
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Male mate preference against tail-elongated females in the barn swallow |
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Single-Cell Transcriptome Analyses Reveal the Cell Diversity and Developmental Features of Human Gastric and Metaplastic Mucosa |
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Loss of heterozygosity spectrum varies with ploidy levels in natural yeast populations |
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Bayesian species distribution models integrate presence-only and presence-absence data to predict deer distribution and relative abundance. |
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CRISPR loss of function screening to identify genes involved in human primordial germ cell-like cells development |
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MPS1 localizes to microtubule-attached kinetochores and actively promotesmicrotubule release |
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Deconstructing cold-induced brown adipocyte neogenesis in mice |
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PP6-regulated Aurora A activity towards NDC80 limits mitotic spindle size to prevent micronucleation |
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Hetero-oligomerization of TDP-43 carboxy-terminal fragments with cellular proteins contributes to proteotoxicity |
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Deep mutational scanning of essential bacterial proteins can guide antibiotic development |
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Identification and characterisation of potent anti-MRSA phloroglucinol derivatives of Dryopteris crassirhizoma Nakai |
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Neuroanatomical and Functional Consequences of Oxytocin Treatment at Birth |
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Oxytocin activity in the Paraventricular and Supramammillary Nuclei of the Hypothalamus is Essential for Social Recognition Memory in Rats |
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Lasting consequences on physiology and social behavior following cesarean delivery in prairie voles |
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A critical role for touch neurons in a skin-brain pathway for stress resilience |
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Time Lagged Multidimensional Pattern Connectivity (TL MDPC): An EEG/MEG Pattern Transformation Based Functional Connectivity Metric |
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Lactate supply overtakes glucose when neural computational and cognitive loads scale up |
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Involvement of nucleus accumbens D2-MSN projections to the ventral pallidum in anxious-like behavior |
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Cooperative assembly confers regulatory specificity and long-term genetic circuit stability |
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Phenotypic variation and quantitative trait loci for resistance to southern anthracnose and clover rot in red clover |
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A Murine Model of Abductor Insufficiency Accelerates the Development of Hip Osteoarthritis |
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Contrasting parental roles shape sex differences in poison frog space use but not navigational performance |
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An iPSC library from a family with Creutzfeldt-Jakob disease caused by the E200K mutation |
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Tle4 controls both developmental acquisition and postnatal maintenance of corticothalamic projection neuron identity |
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#PeerReview from @eLife of ???????? Towards a molecular mechanism underlying mitochondrial protein import through the TOM-TIM23 complex |
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#PeerReview from @eLife of ???????? Asymmetry of cortical functional hierarchy in humans and macaques suggests phylogenetic conservation and adaptation |
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#PeerReview from @eLife of ???????? BrainPalmSeq: A curated RNA-seq database of palmitoylating and de-palmitoylating enzyme expression in the mouse brain |
2021-12-06 |
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#PeerReview from @eLife of ???????? Aberrant cortical development is driven by impaired cell cycle and translational control in a DDX3X syndrome model |
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Metabolic Implications of Birth via Cesarean Section in Prairie Vole (Microtus ochrogaster) |
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Biomolecular solution X-ray scattering at n2STAR Beamline |
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A survey of mapping algorithms in the long-reads era |
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Patterns of lineage-specific genome evolution in the brood parasitic black-headed duck (Heteronetta atricapilla) |
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Effects of altered cellular ultrastructure on energy metabolism in diabetic cardiomyopathy - an in-silico study |
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Post-injury hydraulic fracturing drives fissure formation in the zebrafish basal epidermal cell layer |
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A therapeutically targetable NOTCH1-SIRT1-KAT7 axis in T-cell Leukemia |
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Condensates of disordered proteins have small-world network structures and interfaces defined by expanded conformations |
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Improved antibody-specific epitope prediction using AlphaFold and AbAdapt |
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ExplaiNN: interpretable and transparent neural networks for genomics |
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Pathogen dependence and inter-individual variability of post-infection reproductive fitness in Drosophila melanogaster |
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Molecular evidence of chemical disguise by the socially parasitic spiny ant Polyrhachis lamellidens (Hymenoptera: Formicidae) when invading a host colony |
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Colony size frequency distribution across gradients of reef health in disturbed coral reefs in Northeast Peninsular Malaysia |
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Analysis of organelle content supports a membrane budding model of platelet biogenesis |
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Differential excretory/secretory proteome of the adult female and male stages of the human blood fluke, Schistosoma mansoni |
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Reliable detection of pyrazinamide antitubercular activity in vitro. |
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Identification of Potent CD43+ Effector CD8+ T cells Elicited After Transplantation |
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The 5-hydroxytryptaminergic Neurons Locating in the Dorsal Raphe Nucleus and Different Receptors of 5-HT Were Implicated in Mediating the Arousal from Sevoflurane Anesthesia |
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Targeting acetyl-CoA metabolism attenuates the formation of fear memories through reduced activity-dependent histone acetylation |
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A global atlas of substrate specificities for the human serine/threonine kinome |
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Twitter as a community communication tool for international neuroscience conferences |
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Transcriptional signature pattern in black, blue and purple wheat and impact on seed pigmentation and other associated features: Comparative transcriptomics, genomics and metabolite profiling |
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Incilius alvarius cell-based synthesis of 5-MeO-DMT |
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DNAscope: High accuracy small variant calling using machine learning |
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A modular intramolecular triplex photo-switching motif that enables rapid and reversible control of aptamer binding activity |
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An improved TurboID pipeline in C. elegans by biochemical depletion of endogenously biotinylated carboxylases |
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Spurious intragenic transcription is a hallmark of mammalian cellular senescence and tissue aging |
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A bifunctional kinase-phosphatase module integrates mitotic checkpoint and error-correction signalling to ensure mitotic fidelity |
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Immunoregulatory subtype of dermal lymphatic endothelial cells at capillary terminals drives lymphatic malformations |
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DEGRONOPEDIA - a web server for proteome-wide inspection of degrons |
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Metabolic shift toward ketosis in asocial cavefish increases social-like collective behavior. |
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Graph-based algorithms for Laplace transformed coalescence time distributions. |
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Interpreting the fossil record and the origination of birds |
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Development of fluoroquinolone resistance through antibiotic tolerance in Campylobacter jejuni |
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Inhibitory interneurons within the deep dorsal horn integrate convergent sensory input to regulate motor performance |
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Ecological Dynamics Imposes Fundamental Challenges in Microbial Source Tracking |
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Two therapeutic CRISPR/Cas9 gene editing approaches revert FTD/ALS cellular pathology caused by a C9orf72 repeat expansion mutation in patient derived cells |
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Breathing dysfunction and alveolar damage in a mouse model of Dravet syndrome |
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Lactational delivery of Triclosan promotes non-alcoholic fatty liver disease in newborn mice |
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The rise of sparser single-cell RNAseq datasets; consequences and opportunities |
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S. cerevisiae cells can grow without the Pds5 cohesin subunit |
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UHMK1 is a novel splicing regulatory kinase |
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Comparative genomic insights into the evolution of Halobacteria-associated "Candidatus Nanohaloarchaeota" |
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Purified cytosolic crystals from Bacillus thuringiensis as a novel active pharmaceutical ingredient (API) |
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Integration of metabolism and regulation reveals rapid adaptability to growth on non-native substrates. |
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Acute Vaping of a golden Syrian Hamster is Feasible and Leads to Nicotine-Dependent Respiratory Tract Inflammation |
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Mechanism of treatment-free remission in patients with chronic myeloid leukemia revealed by a computational model of CML evolution |
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Super-exponential growth and stochastic shape dynamics in rod-like bacteria |
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Surveying non-visual arrestins reveals allosteric interactions between functional sites |
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Probing the force-from-lipid mechanism with synthetic polymers |
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Lipid nanoparticle topology regulates endosomal escape and delivery of RNA to the cytoplasm |
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A comprehensive assay of social motivation reveals sex-differential roles of ASC-associated genes and oxytocin |
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Radiation and diversification of GATA-domain-containing proteins in the genus Caenorhabditis |
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Environmental DNA reveals invasive crayfish microbial associates and ecosystem-wide biodiversity before and after eradication |
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Nucleoli and the nucleoli-centromere association are dynamic during normal development and in cancer |
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Epitranscriptomic Modification of MicroRNA Increases Atherosclerosis Susceptibility |
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Butyrate differentiates permissiveness to Clostridioides difficile infection and influences growth of diverse C. difficile isolates |
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Somatic hypermutation spectra are independent of the local transcriptional and epigenetic landscape |
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Increased GABA transmission to GnRH neurons after intrahippocampal kainic acid injection in mice is sex-specific and associated with estrous cycle disruption |
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Retigabine Suppresses Loss of Force in a Mouse Model of Hypokalemic Periodic Paralysis |
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High-throughput, real-time monitoring of engineered skeletal muscle function using magnetic sensing |
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Robust alignment of single-cell and spatial transcriptomes with CytoSPACE |
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A GATA factor radiation in Caenorhabditis rewired the endoderm specification network |
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Cerebellum Directly Modulates the Substantia Nigra Dopaminergic Activity |
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Optimal population turnover regimes for cultural evolution depend on network size, density and behavioral transmissibility |
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Hematopoietic stem cells are a long-term reservoir for trained immunity in a mouse model of chronic autoimmune disease |
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Cortical circuits modulate mouse social vocalizations |
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Divergent projections from Locus Coeruleus to the cortico-basal ganglia system and ventral tegmental area of the zebra finch. |
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Local synaptic inhibition mediates cerebellar pattern separation necessary for learned sensorimotor associations |
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The petrous bone contains high concentrations of osteocytes: one possible reason why ancient DNA is better preserved in this bone. |
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Determination of heavy metals in blood of nesting Kemps Ridley turtles ( Lepidochelys kempii ) at Rancho Nuevo sanctuary, Tamaulipas, Mexico. |
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Mutation in the matricellular gene fibulin-4 leads to endothelial dysfunction in resistance arteries |
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The abundances and occurrences of foliar microbes are poorly predicted by variation in plant traits and abiotic conditions |
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AGS3 antagonizes LGN to balance oriented cell divisions and cell fate choices in mammalian epidermis |
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Lysogenized phages of methanotrophic bacteria show a broad and untapped genetic diversity |
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Mechanoreceptor signal convergence and transformation in the dorsal horn flexibly shape a diversity of outputs to the brain |
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The Adaptor Protein 2 (AP2) complex modulates habituation and behavioral selection across multiple pathways and time windows |
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A Remarkable Adaptive Paradigm Of Heart Performance And Protection Emerges In Response To The Constitutive Challenge Of Marked Cardiac-Specific Overexpression Of Adenylyl Cyclase Type 8 |
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A Mesenchymal Cell Niche in Skin for Acute Myeloid Leukemia |
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Quantification and statistical modeling of Chromium-based single-nucleus RNA-sequencing data |
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Systematic Analysis of Mobile Genetic Elements Mediating β-lactamase Gene Amplification in Non-Carbapenemase-Producing Carbapenem Resistant Enterobacterales Bloodstream Infections |
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Emergent coexistence in multispecies microbial communities |
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Septin-Mediated RhoA Activation Engages the Exocyst Complex to Recruit the Cilium Transition Zone |
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Myriocin remodels sphingolipids and modulates proteostasis networks to enhance longevity |
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Repurposed drugs and their combinations prevent morbidity-inducing dermonecrosis caused by diverse cytotoxic snake venoms |
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PGC1β and ERRα promote glutamine metabolism and colorectal cancer survival via transcriptional regulation of PCK2 |
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Oncogenic KRAS alters splicing factor phosphorylation and alternative splicing in lung cancer |
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Humanized CAR T cells targeting p95HER2 |
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Epigenetic plasticity via adaptive DNA hypermethylation and clonal expansion underlie resistance to oncogenic pathway inhibition in pancreatic cancer |
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Buforin II-Escherichia coli's DNA interactome: Detailed biophysical characterization revealed nanoscale complexes likely formed by DNA supercoiling |
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Ratiometric NAD+ sensors reveal subcellular NAD+ modulators |
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Design of a mucin-selective protease for targeted degradation of cancer-associated mucins |
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Actin filaments couple the protrusive tips to the nucleus through the I-BAR domain protein IRSp53 for migration of elongated cells on 1D fibers |
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Sphingolipid depletion inhibits bulk endocytosis while triggering selective clearance of the methionine transporter Mup1 |
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An apical protein, Pcr2, is required for persistent movement by the human parasite Toxoplasma gondii |
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Cell survival enabled by leakage of a labile metabolic intermediate |
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Heterologous Expression of NoxA Confers Aerotolerance in Clostridium sporogenes |
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Statistical significance and biological relevance: The case of Nosema ceranae and winter colony losses. |
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Differences in Gut Microbiota Assembly Alter Its Ability to Metabolize Dietary Polysaccharides and Resist Clostridioides difficile Colonization |
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Cytoplasmic TDP-43 accumulation drives changes in C-bouton number and size in a mouse model of sporadic Amyotrophic Lateral Sclerosis |
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Recognition of BRAF by CDC37 and Reevaluation of the Activation mechanism for the Class 2 BRAF-L597R mutant |
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Conformational Dynamics and Mechanisms of Client Protein Integration into the Hsp90 Chaperone Controlled by Allosteric Interactions of Regulatory Switches: Perturbation-Based Network Approach for Mutational Profiling ... |
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Characterization and structure of the human lysine-2-oxoglutarate reductase domain, a novel therapeutic target for treatment of glutaric aciduria type 1 |
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Omicron breakthrough infections in vaccinated or previously infected hamsters |
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Structural basis for substrate selection by the SARS-CoV-2 replicase |
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The spike-stabilizing D614G mutation interacts with S1/S2 cleavage site mutations to promote the infectious potential of SARS-CoV-2 variants |
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Deep mutational scanning identifies SARS-CoV-2 Nucleocapsid escape mutations of currently available rapid antigen tests |
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SARS-CoV-2 Spike protein suppresses CTL-mediated killing by inhibiting immune synapse assembly |
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SARS-CoV-2 Infects Peripheral and Central Neurons of Mice Before Viremia, Facilitated by Neuropilin-1 |
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Revealing druggable cryptic pockets in the Nsp-1 of SARS-CoV-2 and other β-coronaviruses by simulations and crystallography |
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Global predictions for the risk of establishment of Pierce's disease of grapevines |
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CRISPR-Cas provides limited phage immunity to a prevalent gut bacterium in gnotobiotic mice |
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Genome-wide association mapping reveals genes underlying population-level metabolome diversity in a fungal crop pathogen |
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Ephemeral Resource Availability Makes Wild Guppies More Social |
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Genome size changes by duplication, insertion and divergence in Caenorhabditis worms |
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The Batten disease protein CLN3 is important for stress granules dynamics and translational activity. |
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Structure of nucleosome-bound human PBAF complex |
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EZH2 interacts with MEG3 to directly regulate integrin signaling and endothelial cell function |
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Spatial memory training reverses GirK channels modulation in the transgenic APPSw,Ind Alzheimer's disease mouse model |
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Systematic evaluation of high level visual deficits and lesions in posterior cerebral artery stroke |
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Evidence for different greater-persistence strategies under lower and higher challenge for alcohol in female rats |
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Changes in Tissue Protein N-Glycosylation and Associated Molecular Signature Occur in the Human Parkinsonian Brain in a Region-Specific Manner |
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Artificial Alzheimer's - visualizing the process of memory decay, confusion and death in a simple Neural Network Model of Associative Memory |
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Computational conjugate adaptive optics for longitudinal through-skull imaging of cortical myelin |
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Rab11 regulates autophagy at dendritic spines in an mTOR- and NMDA-dependent manner |
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Minimally invasive delivery of peptides to the spinal cord for behavior modulation |
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Single cell analysis of the dorsal V-SVZ reveals differential quiescence of postnatal pallial and subpallial neural stem cells driven by TGFbeta/BMP-signalling |
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Connectivity by the Frontal Aslant Tract (FAT) explains local functional specialization of the superior and inferior frontal gyri in humans while choosing predictive over reactive strategies: a tractography-guided TMS ... |
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A Novel Strategy for Dynamic Modelling of Genome-Scale Interaction Networks |
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Rudimentary Structure-Activity-Relationship study of the MMV Pathogen Box compound MMV675968 (2,4-diaminoquinazoline) unveils novel inhibitors of Trypanosoma brucei brucei DHFR enzyme |
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Interplay between VSD, pore and membrane lipids in electromechanical coupling in HCN channels |
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Measuring single-virus fusion kinetics using an assay for nucleic acid exposure |
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Alignment-free metal ion-binding site prediction from protein sequence through pretrained language model and multi-task learning |
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Succinylated lysine residue prediction revisited |
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Correcting Modification-Mediated Errors in Nanopore Sequencing by Nucleotide Demodification and in silico Correction |
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Succinct k-mer Set Representations Using Subset Rank Queries on the Spectral Burrows-Wheeler Transform (SBWT) |
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Scalable power analysis and effect size exploration of microbiome community differences with Evident |
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recountmethylation enables flexible analysis ofpublic blood DNA methylation array data |
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Automated optimisation of solubility and conformational stability of antibodies and proteins |
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Bees differentiate sucrose solution from water at a distance |
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Host and pathogen drivers of infection-induced changes in social aggregation behavior |
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Molecular Phylogenetics of HIV-1 Subtypes in African Populations: A Case Study of Sub-Saharan African Countries |
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Metabolic, Fibrotic, and Splicing Pathways Are All Altered in Emery-Dreifuss Muscular Dystrophy Spectrum Patients to Differing Degrees |
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Geometric morphometric analysis reveals cranial shape divergence and asymmetry in extinct and extant species of big cats (Carnivora: Felidae) |
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Age-specific and Sex-specific Nectar and Pollen Use by a Butterfly Pollinator |
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Semi-field and surveillance data define the natural diapause timeline for Culex pipiens across the United States |
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Human primed and naive PSCs are both competent indifferentiating into bona fide trophoblast stem cells |
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Processing of task-irrelevant sounds during typical everyday activities in children |
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Drosophila embryos spatially sort their nutrient stores to facilitate their utilization |
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Novel insights into the pig gut microbiome using metagenome-assembled genomes |
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Competition-cooperation in the chemoautotrophic ecosystem of Movile Cave - first metagenomic approach on sediments |
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Pangenome evolution in Escherichia coli is sequence type, not phylogroup, specific |
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Narrowband gamma oscillations propagate and synchronize throughout the mouse thalamocortical visual system |
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The Queensland Twin Adolescent Brain Project, a longitudinal study of adolescent brain development |
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Model metamers illuminate divergences between biological and artificial neural networks |
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Variational and phase response analysis for limit cycles with hard boundaries, with applications to neuromechanical control problems |
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Gpr88 deletion impacts motivational control independently of striatal dopamine function |
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A single closed head injury in mice induces chronic, progressive white matter atrophy and increased phospho-tau expressing oligodendrocytes |
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Prelimbic cortex neural encoding dynamically tracks expected outcome value |
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Accurate speech decoding requires high-resolution neural interfaces |
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Whole-transcriptomic profiling of human cerebral cortex tissues reveals microglia-associated molecular subtypes |
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Coordination of Pickpocket ion channel delivery and dendrite growth in Drosophila sensory neurons |
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Maximum a posteriori natural scene reconstruction from retinal ganglion cells with deep denoiser priors |
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Hippocampus as a generative circuit for predictive coding of future sequences |
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Extended practice improves the accuracy and efficiency of goal-directed reaching guided by supplemental kinesthetic vibrotactile feedback |
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Temporal origin of mouse claustrum and development of its cortical projections |
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Super-resolved imaging deciphers ligand dependent membrane behaviour of the onco-immunogenic CCR5 receptor. |
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An Optimized Buffer for Repeatable Multicolor STORM |
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Computational modelling of local fluctuations causing transient solvent exposure of protein amides |
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Complexity of enhancer networks predicts cell identity and disease genes revealed by single-cell multi-omics analysis |
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Rapid estimation of cortical neuron activation thresholds by transcranial magnetic stimulation using convolutional neural networks |
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Goat kid recognition of their mothers' calls is not impacted by changes in source-filter parameters. |
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Direct and indirect phenotypic effects on sociability indicate potential to evolve |
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Insular holobionts: persistence and seasonal plasticity of the Balearic wall lizard (Podarcis lilfordi) gut microbiota |
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Brain morphometric changes in congenitally blind subjects: a 7 Tesla MRI study |
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Transient and sustained visuomotor selection during working-memory guided behavior. |
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Hindlimb Muscle Representations in Mouse Motor Cortex Defined by Viral Tracing |
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Parieto-frontal Oscillations Show Hand Specific Interactions with Top-Down Movement Plans |
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APOE modulates microglial immunometabolism in response to age, amyloid pathology, and inflammatory challenge |
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Spatial Transcriptomics-correlated Electron Microscopy |
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The limitations of phenotype prediction in metabolism |
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#PeerReview from @eLife of ???????? Multistep loading of PCNA onto DNA by RFC |
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#PeerReview from @ReviewCommons of ???????? The actin assembly requirements of the formin Fus1 to build the fusion focus |
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Root-specific activation of plasma membrane H+-ATPase 1 enhances plant growth and shoot accumulation of nutrient elements under nutrient-poor conditions in Arabidopsis thaliana |
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Conserved and variable responses of the HEAT SHOCK FACTOR transcription factor family in maize and Setaria viridis |
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Ter-Seq: A high-throughput method to stabilize transient ternary complexes and measure associated kinetics |
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Multivariate optimization of k for k-nearest-neighbor feature selection with dichotomous outcomes: complex associations, class imbalance, and application to RNA-Seq in Major Depressive Disorder |
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Higher-order interactions shape microbial interactions as microbial community complexity increases |
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Non-invasive vagus nerve stimulation in a hungry state decreases heart rate variability and wanting of a palatable drink |
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Study of the glycome of synovial mast cells in normal tissues, osteoarthritis and rheumatoid arthritis reveals MGAT5 activity in these and endochondral cells. |
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Periostin+ stromal cells guide lymphovascular invasion by cancer cells |
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A "cooperative collaboration" between HAND2 and MYCN shapes neuroblastoma cell identity |
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GRHL2 enhances phosphorylated estrogen receptor DNA-binding and regulates ER-mediated transcriptional activation and repression |
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Mechanosensor Piezo1 Mediates Bimodal Patterns of Intracellular Signaling |
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DProQ: A Gated-Graph Transformer for Protein Complex Structure Assessment |
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Detection of outlier methylation from bisulfite sequencing data with novel Bioconductor package BOREALIS |
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JEDII: Juxtaposition Enabled DNA-binding Interface Identifier |
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Convolutions are competitive with transformers for protein sequence pretraining |
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Spatially selective stimulation of the pig vagus nerve to modulate target effect versus side effect |
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#PeerReview from @eLife of ???????? LabNet: hardware control software for the Raspberry Pi |
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#PeerReview from @eLife of ???????? The mycobacterial mutasome: composition and recruitment in live cells |
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#PeerReview from @eLife of ???????? An M protein coiled coil unfurls and exposes its hydrophobic core to capture LL-37 |
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#PeerReview from @eLife of ???????? Measurements of damage and repair in aging mice and humans reveals that robustness and resilience decrease with age, operate over broad timescales, and are affected differently by ... |
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#PeerReview from @eLife of ???????? Mettl3-mediated m6A modification of Fgf16 restricts cardiomyocyte proliferation during heart regeneration |
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A comparative study of structural variant calling strategies using the Alzheimer's Disease Sequencing Project's whole genome family data |
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Strength of selection potentiates distinct adaptive responses in an evolution experiment with outcrossing yeast |
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Population estimate, natural history and conservation of the melanistic Iguana iguana population on Saba, Caribbean Netherlands |
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Whole-genome scanning reveals selection mechanisms in epipelagic Chaetoceros diatom populations |
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Exploring the mosquito-arbovirus network: a survey of vector competence experiments |
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Scent mark signal investment predicts fight dynamics in house mice |
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Timed Notch Inhibition drives Photoreceptor fate specification in Human Retinal Organoids |
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mNeonGreen-tagged fusion proteins and nanobodies reveal localization of tropomyosin to patches, cables, and contractile actomyosin rings in live yeast cells |
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Oxidative Stress Induced Senescence Gives Rise to Transcriptionally Distinct Physiological States |
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Protein Lactylation and Metabolic Regulation of the Zoonotic Parasite Toxoplasma gondii |
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The contributory effects of the VH families and CH regions of multimeric IgM on its interaction with Fc(mu)R, and antigen. |
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Homeostatic changes maintain the gain control of spinal motoneurones across the lifetime of C57BL/6J mice |
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SARM1 promotes axonal, synaptic, and mitochondrial pathologies in Charcot-Marie-Tooth disease type 2A |
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Intelligibility improves the perception of speech rhythm |
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Developmental Coordination Disorder: What Can We Learn From Recombinant Inbred Mice Using Motor Learning Tasks and Quantitative Trait Locus Analysis |
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Nerve pathology is prevented by linker proteins in mouse models for LAMA2-related muscular dystrophy |
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The canonical Wnt signaling pathway is not a promising therapeutic target for PNS regeneration enhancement |
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Single-cell Ca2+ parameter inference reveals how transcriptional states inform dynamic cell fates |
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An electrogenetic toggle switch design |
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#PeerReview from @eLife of ???????? Control of Craniofacial Development by the Collagen Receptor, Discoidin Domain Receptor 2 |
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The TERT promoter is polycomb-repressed in neuroblastoma cells with long telomeres |
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Effects of Familial Alzheimer's Disease Mutations on the Folding Free Energy and Dipole-Dipole Interactions of the Amyloid β-Peptide |
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Pangenomic genotyping with the marker array |
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A general framework for the combined morphometric, transcriptomic, and physiological analysis of cells using metric geometry |
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Confident Clustering via PCA Compression Ratio and ItsApplication to Single-cell RNA-seq Analysis |
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Quantitative Characterization of Duodenal Gastrinoma Autofluorescence using Multi-photon Microscopy |
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Creating a thermostable beta-glucuronidase switch for homogeneous immunoassay by disruption of conserved salt bridges at diagonal interfaces |
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Model-based intensification of CHO cell cultures: one-step strategy from fed-batch to perfusion |
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Oriented evening flight behaviour in the Bogong moth revealed through automated video tracking |
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Impaired Epigenesis of Imprinting Predispositions Causes Autism-like Behavioral Phenotypes in Domestic Chicks |
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Firefly-inspired vocabulary generator for communication in multi-agent systems |
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#PeerReview from @eLife of ???????? Structure of Mycobacterium tuberculosis Cya, an evolutionary ancestor of the mammalian membrane adenylyl cyclases |
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#PeerReview from @eLife of ???????? Integration of visual and antennal mechanosensory feedback during head stabilization in hawkmoths |
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#PeerReview from @eLife of ???????? Adaptation of Drosophila larva foraging in response to changes in food distribution |
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#PeerReview from @eLife of ???????? Endothelial-derived sphingolipids are required for vascular development and systemic lipid homeostasis |
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An update to the database for Acinetobacter baumannii capsular polysaccharide locus typing extends the extensive and diverse repertoire of genes found at and outside the K locus |
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Genetic, vocal, and body size divergence across the Northern Peruvian Low supports two species within the Masked Flowerpiercer (Diglossa cyanea) |
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Space-time home range estimates and resource selection for the Critically Endangered Philippine Eagle on Mindanao |
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Substantial seagrass blue carbon pools in the southwestern Baltic Sea are spatially heterogeneous, mostly autochthonous, and include relics of terrestrial peatlands |
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A social media-based framework for quantifying temporal changes to wildlife viewing intensity: Case study of sea turtles before and during COVID-19 |
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Western diet-induced shifts in the maternal microbiome are associated with altered microRNA expression in baboon placenta and fetal liver |
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Sex-specific topological differences in germline cell lineage trees |
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Spatiotemporal dynamics of membrane surface charge regulates cell polarity and migration |
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Gene expression profiling reveals B cells are highly educated by the pancreatic environment during autoimmune diabetes |
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Dynamic Structure Of Motor Cortical Neuron Co-Activity Carries Behaviorally Relevant Information |
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Spatiotemporal organization of human sensorimotor beta burst activity |
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Bisected graph matching improves automated pairing of bilaterally homologous neurons from connectomes |
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AI-guided screen identifies probucol-mediated mitophagy enhancement through modulation of lipid droplets |
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Basic Leucine Zippers: Aureochromes Versus the Rest |
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Effect of pressure insole sampling frequency on peak force accuracy during running |
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Targeting TACC3 represents a novel vulnerability in highly aggressive breast cancers with centrosome amplification |
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Cell-to-cell variability of dynamic CXCL12-CXCR4 signaling and morphological processes in chemotaxis |
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Self-organized canals enable long range directed material transport in bacterial communities |
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Resolution doubling in light-sheet microscopy via oblique plane structured illumination |
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Metadata retrieval from genomics database with ffq |
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Serverless Prediction of Peptide Properties with Recurrent Neural Networks |
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TransCell: In silico characterization of genomic landscape and cellular responses from gene expressions through a two-step deep transfer learning |
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Guided construction of single cell reference for human and mouse lung |
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Characterizing metabolism from bulk and single-cell RNA-seq data using METAFlux |
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Characterizing transition cells in developmental processes from scRNA-seq data |
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A 512-ch dual-mode microchip for simultaneous measurements of electrophysiological and neurochemical activities |
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Brain-muscle connectivity during gait: corticomuscular coherence as quantification of the cognitive reserve |
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Delayed benefits for fallow bucks: more fights decrease same day mating success, but may increase matings the next day |
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A binocular perception deficit characterizes prey pursuit in developing mice |
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The largest haplotype-phased and chromosome-scale genome assembly of the fungal pathogen, Puccinia polysora, by HiFi reads and Hi-C data |
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Nucleotide resolution genetic mapping in pigs by publicly accessible whole genome imputation |
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pastclim: an R package to easily access and use paleoclimatic reconstructions |
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Museum specimens of a landlocked pinniped reveal recent loss of genetic diversity and unexpected population connections |
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Non-aging despite high mutation rate - genomic insights into the evolution of Hydra |
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Camera-based monitoring of Bogong moths in Alpine Australia reveals drivers of migratory behaviour |
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Wnt signalling, cell fate determination and anteroposterior polarity of the skate gill arch skeleton |
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ABHD6 selectively controls Gq-dependent increases in 2-AG production |
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Long-term functional regeneration of radiation damaged salivary glands through delivery of a neurogenic hydrogel |
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Mathematical modeling suggests that a single Plasmodium-specific CD8 T cell can eliminate a malaria liver stage in mice |
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Control of flight responses by a non-canonical corticolimbic pathway. |
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Larger cerebral cortex is genetically correlated with greater frontal area and dorsal thickness |
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The molecular fingerprint of stress resilience |
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Sparse RNNs can support high-capacity classification |
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Deep Learning-Based Parameter Estimation for Neurophysiological Models of Neuroimaging Data |
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QTL mapping for seed morphology using the instance segmentation neural network in Lactuca spp. |
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In-situ lipid profiling of insect pheromone glands by Direct Analysis in Real Time Mass Spectrometry |
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NON-TARGETED METABOLOMICS REVEAL DIFFERENCES IN THE METABOLIC PROFILE OF THE FALL ARMYWORM STRAINS WHEN FEEDING DIFFERENT FOOD SOURCES |
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A Preclinical Model to Investigate Normal Tissue Damage Following Fractionated Radiotherapy to the Head and Neck |
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Human intracranial pulsatility during the cardiac cycle: a computational modelling framework |
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A framework to trace microbial engraftment at the strain level during fecal microbiota transplantation |
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Reproducing extracellular matrix adverse remodelling of non-ST myocardialinfarction in a large animal model |
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Single molecule multi-omics reveals context-dependent regulation of enhancers by DNA methylation |
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Spatial and temporal diversity of positive selection on shared haplotypes at the PSCA locus among worldwide human populations |
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A comparison between Mini-loop mediated isothermal amplification and polymerase spiral reaction for selective amplification of short template DNA |
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Humans parsimoniously represent auditory sequences by pruning and completing the underlying network structure |
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Ancestral state reconstruction suggests repeated losses of recruitment communication during ant evolution (Hymenoptera: Formicidae) |
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3D flightpaths reveal the development of spatial memory in wild hummingbirds |
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Discovery and pre-clinical evaluation of antibodies to the NKG2A inhibitory receptor |
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Allosteric Inhibition of PTP1B by a Nonpolar Terpenoid |
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#PeerReview from @eLife of ???????? Modeling osteoporosis to design and optimize pharmacologic therapies comprising multiple drug types |
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#PeerReview from @eLife of ???????? Robust group- but limited individual-level (longitudinal) reliability and insights into cross-phases response prediction of conditioned fear |
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#PeerReview from @eLife of ???????? Locally synchronized ciliary domains and tissue-scale cilia alignment underlie global metachronal wave patterns |
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Disentangling the historical routes to community assembly in the global epicentre of biodiversity |
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The Microbiome and Volatile Organic Compounds Reflect the State of Decomposition in an Indoor Environment |
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The majority of microorganisms in gas hydrate bearing subseafloor sediments ferment macromolecules |
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Using nanopore sequencing to obtain complete genomes from saliva samples |
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Klebsiella pneumoniae L-Fucose metabolism promotes gastrointestinal colonization and modulates its virulence determinants |
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Distinct types of multicellular aggregates in Pseudomonas aeruginosa liquid cultures |
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A reproducible and tunable synthetic soil microbial community provides new insights into microbial ecology |
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PGC-1β maintains mitochondrial metabolism and restrains inflammatory gene expression |
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Aiolos modulates the TFH and CD4-CTL differentiation programs via reciprocal regulation of the Zfp831/TCF-1/Bcl-6 axis and CD25 |
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Diverse task-driven modeling of macaque V4 reveals functional specialization towards semantic tasks |
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Precision motor timing via scalar input fluctuations |
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C5aR1 antagonism alters microglial polarization and mitigates disease progression in a mouse model of Alzheimers disease |
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Enhancer plasticity sustains oncogenic transformation and progression of B-Cell Acute Lymphoblastic leukemia. |
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Mechanism of Mg2+ Mediated Encapsulation of an Anionic Cognate Ligand in a Bacterial Riboswitch |
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Rdh54 stabilizes Rad51 at displacement loop intermediates to regulate genetic exchange between chromosomes |
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Membrane-Bound O-Acyltransferase 7 (MBOAT7)-Driven Lysophosphatidylinositol (LPI) Acylation in Adipocytes Contributes to Systemic Glucose Homeostasis |
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Comprehensive analysis of the effect of mRNA sequences on translation efficiency and accuracy |
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Overexpression screen of chromosome 21 genes reveals modulators of Sonic hedgehog signaling relevant to Down syndrome |
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High Frequency of Dynamic Rearrangements in CRISPR Loci |
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Expanded Distribution and Predicted Suitable Habitat for the Critically Endangered Yellow-tailed Woolly Monkey (Lagothrix flavicauda) in Peru |
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Mitochondrial genome recovery by ATFS-1 is essential for development following starvation |
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Effects of netarsudil-family Rho kinase inhibitors on human trabecular meshwork cell contractility and actin remodeling using a bioengineered ECM hydrogel |
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Combined omics unravels the molecular mechanism of golden-leaf coloration in Koelreuteria paniculata 'jinye' |
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A type IV Autotaxin inhibitor ameliorates acute liver injury and non-alcoholic steatohepatitis in mice |
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Held out wings RNA binding activity in the cytoplasm during early spermatogenesis |
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Functional gene analysis and cultivation experiments predict the degradation of diverse extracellular polysaccharides by ubiquitous taxa in pustular microbial mats from Shark Bay, Western Australia |
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The evolutionary potential of the influenza A virus hemagglutinin is highly constrained by intersegment epistasis |
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Targeting Nup358/RanBP2 by a viral protein disrupts stress granule formation |
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A Microfluidic Chip for LAMP-based Multiplex Detection of Pathogen |
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Lipopolysaccharide synthesis and traffic in the envelope of the pathogen Brucella abortus |
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The role of the environment in transmission of antimicrobial resistance between humans and animals: a modelling study |
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Host adaptation drives genetic diversity in a vector-borne disease system |
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Borg tandem repeats undergo rapid evolution and are under strong selection to create new intrinsically disordered regions in proteins |
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HIV positive patients on antiretroviral therapy have an altered mucosal intestinal but not oral microbiome |
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Programming the lymph node immune response with Amphiphile-CpG induces potent cellular and humoral immunity following COVID-19 subunit vaccination in mice and non-human primates |
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mRNA-based vaccines against SARS-CoV-2 do not stimulate interferon stimulatory gene expression in individuals affected by Aicardi Goutieres Syndrome. |
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The regulatory landscapes of human ovarian ageing |
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Dysfunction of transfer RNA modifications in inflammatory bowel disease |
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Fibroblasts-derived from Pluripotent Cells Harboring a Single Allele Knockout in Two Pluripotency Genes Exhibit DNA Methylation Abnormalities and pluripotency induction Defects |
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Zmiz1 is required for mature β-cell function and mass expansion upon high fat feeding |
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HiCUP-Plus: a fast open-source pipeline for accurately processing large scale Hi-C sequence data |
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The acute phase response in bats (Carollia perspicillata) varied with the time and dose of the immune-challenge |
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Collective directional migration drives the formation of heteroclonal cancer cell clusters |
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Curvature-induced cell rearrangements in biological tissues |
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Eulertigs: minimum plain text representation of k-mer sets without repetitions in linear time |
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DCAlign v1.0: Aligning biological sequences using co-evolution models and informative priors |
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COInr and mkCOInr: Building and customizing a non-redundant barcoding reference database from BOLD and NCBI using a lightweight pipeline. |
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Developmental timing of programmed DNA elimination in Paramecium tetraurelia recapitulates germline transposon evolutionary dynamics |
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Trait-dependent diversification in angiosperms: patterns, models and data |
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Serial depletion of Baltic herring since the Viking Age revealed by ancient DNA and population genomics |
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Profiles of secoiridoids and alkaloids in tissue of susceptible and resistant green ash progeny reveal patterns of induced responses to emerald ash borer in Fraxinus pennsylvanica |
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Using NAMs to characterize chemical bioactivity at the transcriptomic, proteomic and phosphoproteomic levels |
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Interplay between Polycomb PCGF protein interactomes revealed by screening under endogenous conditions |
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Cellular senescence in malignant cells promotes tumor progression in mouse and patient Glioblastoma |
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Increased CaMKK2 expression is an adaptive response that maintains the fitness of tumor-infiltrating natural killer cells |
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A method for morphological feature extraction based on variational auto-encoder : an application to mandible shape |
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PhiDsc: Protein functional mutation Identification by 3D Structure Comparison |
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Lack of evidence for increased transcriptional noise in aged tissues |
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Improved deterrence of birds using an artificial predator, the RobotFalcon |
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Extremely low level of genetic diversity in Gentiana yakushimensis, an endangered species in Yakushima Island, Japan |
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Massive Horizontal Gene Transfer in Amphioxus Illuminates the Early Evolution of Deuterostomes |
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Two different mental disc forms in the Tashan cave Garra: different species or ecotypes? |
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Soluble cyclase-mediated nuclear cAMP synthesis is sufficient for cell proliferation |
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Mating disrupts morning anticipation in Drosophila melanogaster females 2 |
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Determination of cross-tissue and tissue-specific aging changes in murine proteomes |
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PPARγ/ETV2 Axis Regulates Endothelial-to-Mesenchymal Transition in Pulmonary Hypertension |
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Cross regulation between the molecular clock and kidney inflammatory, metabolic and fibrotic responses |
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Attention-aware contrastive learning for predicting T cell receptor-antigen binding specificity |
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Longitudinal white matter alterations in SIVmac239 infected rhesus monkeys with and without regular cART treatment |
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Pervasive gene duplications as a major evolutionary driver of coral biology |
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Highly Dynamic Gene Family Evolution Suggests Changing Roles for PON Genes Within Metazoa |
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Genetic diversity varies with species traits and latitude in predatory soil arthropods (Myriapoda: Chilopoda) |
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Comprehensive analysis of pathways in Coronavirus 2019 (COVID-19) using an unsupervised machine learning method |
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Voltage-Dependent Ca2+ Release Is Impaired in Hypokalemic Periodic Paralysis Caused by CaV1.1-R528H but not by NaV1.4-R669H |
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Pdx1 expression in hematopoietic cells activates Kras-mutation to drive leukemia in KC (Pdx1-Cre ; LSL-KrasG12D/+) mice |
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A computational proposal for tracking multiple molecules in a multi-focus confocal setup |
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Physical Obstacles Constrain Behavioral Parameter Space of Successful Localization in Honey Bee Swarms |
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Between heuristics and optimality: Flexible integration of cost and evidence during information sampling |
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COVID-19 lockdown reveals fish density may be much higher in marine reserves |
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The Wnt/TCF7L1 transcriptional repressor axis drives primitive endoderm formation by antagonizing naive and formative pluripotency |
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Prenatal valproic acid-induced autism marmoset model exhibits higher salivary cortisol levels |
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EDGE2: advancing the prioritisation of threatened evolutionary history for conservation action |
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Endothelial neuropilin-1 and neuropilin-2 are essential for tumour angiogenesis |
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scMoMaT: Mosaic integration of single cell multi-omics matrices using matrix trifactorization |
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Rtapas: An R package to assess cophylogenetic signal between two evolutionary histories |
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Conservation of nitrogenase functionality over long timescales |
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USP11 promotes endothelial apoptosis-resistance in pulmonary hypertension by deubiquitinating HINT3 |
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Genomic screening reveals UBA1 as a potent and druggable target in c-MYC-high TNBC models |
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Extraintestinal roles of intestinal vitamin D receptor in protecting against dysbiosis and tumorigenesis in breast cancer |
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Ultra-small bispecific fusion protein augments tumor penetration and treatment efficacy for pancreatic cancer |
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MCell4 with BioNetGen: A Monte Carlo Simulator of Rule-Based Reaction-Diffusion Systems with Python Interface |
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Bayesian statistics improves biological interpretability of metabolomics data from human cohorts |
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INSISTC: Incorporating Network Structure Information for Single-Cell Type Classification |
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HARIBOSS: a curated database of RNA-small molecules structures to aid rational drug design |
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Semi-supervised deep learning with graph neural network for cross-species regulatory sequence prediction |
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Considerations for Deconvolution: A Case Study with GTEx Coronary Artery Tissues |
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Long-duration and non-invasive photoacoustic imaging of multiple anatomical structures in a live mouse using a single contrast agent |
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Cartilage-penetrating hyaluronic acid hydrogel preserves tissue content and reduces chondrocyte catabolism |
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The Effects of Negative Periocular Pressure on Biomechanics of the Optic Nerve Head and Cornea: A Computational Modeling Study |
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Plasticity of threespine stickleback nuptial signals: laboratory manipulation of ambient light causes a shift in male reflectance patterns. |
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Strain level centromere variation influences CENP-A association dynamics and centromere function |
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Domestication of different varieties in the cheese-making fungus Geotrichum candidum |
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Stronger sexual dimorphism in fruit flies may be favored when congeners are present and females actively search for mates |
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Evolution and diversification dynamics of butterflies |
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Cosmopolitan Scolytinae: strong common drivers but too many singularities for accurate prediction |
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Fruitful female fecundity after feeding Gryllodes sigillatus royal jelly |
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Microglia maintain homeostatic conditions in the developing rostral migratory stream. |
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Neural learning rules for generating flexible predictions and computing the successor representation |
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Self-generation of goal-directed choices in a distributed dopaminergic andprefrontal circuit |
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Glia-mediated cerebellar pain modulation |
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Associations between abstract working memory abilities and brain activity underlying long-term recognition of auditory sequences |
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Midbrain-Hippocampus Structural Integrity Selectively Predicts Motivated Memory Encoding |
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Disease-modifying effects of sodium selenate in a model of drug-resistant, temporal lobe epilepsy. |
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Second-generation transfer mediates efficient propagation of ICEBs1 in biofilms. |
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Disinhibition of Rab10 gates AMPAR insertion and spine enlargement during long-term potentiation |
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Boosting chloroplast ribosome biogenesis by a plastidial DEAD-box RNA helicase is critical for high light acclimation |
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OGG1 inhibitor TH5487 alleviates allergic airway inflammation in mice |
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ER translocation of suboptimal targeting sequences depends on Sec61β/Sbh1 and its phosphorylation |
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Homeostatic feedback between lysosomal mTORC1 and mTORC2-AKT signaling controls nutrient uptake in brown adipose tissue |
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Lung macrophages utilize cathepsin K-dependent phagosomal machinery to degrade intracellular collagen |
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The Nse5/6-like SIMC1-SLF2 Complex Localizes SMC5/6 to Viral Replication Centers |
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#PeerReview from @eLife of ???????? The giant Staphylococcus epidermidis surface protein Embp binds selectively to fibrillated fibronectin through a Velcro-like mechanism |
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#PeerReview from @eLife of ???????? Lifting the ban on nuclear import activates Gdown1-mediated modulation of global transcription and facilitates adaptation to cellular stresses |
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#PeerReview from @eLife of ???????? A single nucleotide variant in the PPARgamma-homolog Eip75B affects fecundity in Drosophila |
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Efficient querying of genomic databases for single-cell RNA-seq with gget |
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FliL has a conserved function in diverse microbes to negatively modulate motor output via its N-terminal region |
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The Indirect Pathway of the Basal Ganglia Promotes Negative Reinforcement, But Not Motor Suppression |
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Emergent low-frequency activity in cortico-cerebellar networks with motor skill learning |
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Molecular cloning and recombinant protein expression of 9-Lipoxygenase gene from Solanum tuberosum in Pichia pastoris yeast cells |
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Distinct nano-structures support a multifunctional role of actin at presynapses |
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Analysis of the Drosophila Ajuba LIM protein defines functions for distinct LIM domains |
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On the intrinsic curvature of animal whiskers |
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Modeling clonal evolution and oncogenic dependency in vivo in the context of hematopoietic transformation |
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The archaeological potential of the northern Luangwa Valley, Zambia: the Luwumbu basin. |
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Persistence of phenotypic responses to short-term heat stress in the tabletop coral Acropora hyacinthus |
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#PeerReview from @EMBOPress of ???????? UPF3A and UPF3B are redundant and modular activators of nonsense-mediated mRNA decay in human cells |
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A multi-domain connector links the outer membrane and cell wall in deep-branching bacteria |
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#PeerReview from @eLife of ???????? CyTOF-Lec: Single-cell glycomics analysis reveals glycan features defining cells differentially susceptible to HIV |
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Jak2V617F Reversible Activation Shows an Essential Requirement for Jak2V617F in Myeloproliferative Neoplasms |
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Transcriptome profile and clinical characterization of ICOS expression in brain gliomas |
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Chemoproteomics-Enabled Discovery of a Covalent Molecular Glue Degrader Targeting NF-κB |
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Extensive mosaicism by somatic L1 retrotransposition in normal human cells |
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The epigenomic landscape of single vascular cells reflects developmental origin and identifies disease risk loci |
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ERK pathway activation inhibits ciliogenesis and causes defects in motor behavior, ciliary gating, and cytoskeletal rearrangement |
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Carbon signaling protein SbtB possesses redox-regulated apyrase activity to facilitate regulation of bicarbonate transporter SbtA |
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An evolutionary paradigm favoring crosstalk between bacterial two-component signaling systems |
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Analysis of Cyp51 protein sequences shows 4 major Cyp51 gene family groups across Fungi |
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Limited Cross-Species Virus Transmission in a Spatially Restricted Coral Reef Fish Community |
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ParA and its functions that go beyond chromosome segregation in Caulobacter crescentus |
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Growth, organic matter release, aggregation and recycling during a diatom bloom: A model-based analysis of a mesocosm experiment |
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Gut microbiota of homing pigeons shows summer-winter variation under constant diet indicating a substantial effect of temperature |
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A dynamic HIF1alpha-PPARgamma circuit controls a paradoxical adipocyte regulatory landscape |
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Increasing protein stability by inferring substitution effects from high-throughput experiments |
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Lipidomic change in Aedes aegypti female following blood feeding reveals similar changes in functionally related lipids |
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Phenol Sensing in Nature Modulated via a Conformational Switch Governed by Dynamic Allostery |
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Structural analysis of cholesterol binding and sterol selectivity by ABCG5/G8 |
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Impact of genus (Geotrigona, Melipona, Scaptotrigona) in the 1H-NMR organic profile and authenticity test of honey processed in cerumen pots by stingless bees in Ecuador |
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Genomic epidemiology and multilevel genome typing of Australian Salmonella enterica serovar Enteritidis |
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Rap1 uses Canoe-dependent and Canoe-independent mechanisms to regulate apical contractility and allow embryonic morphogenesis without tissue disruption |
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Disruption of Smarce1, a component of the SWI/SNF chromatin remodeling complex, decreases nucleosome stability in mouse embryonic stem cells and impairs differentiation |
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Mutant huntingtin exon-1 impaired GTPCH and DHFR expression in plants and mice |
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Chromosome folding and prophage activation reveal gut-specific genome dynamics of bacteria in the OMM12 consortium |
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Bacteroides muris sp. nov. isolated from the cecum of wild-derived house mice |
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wrmXpress: A modular package for high-throughput image analysis of parasitic and free-living worms |
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Analyses of circRNA expression throughout circadian rhythm reveal a strong link between Cdr1as and light-induced phase shifts in the SCN |
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Structure-Guided Identification of Critical Residues in the Vacuolar Na+,K+/H+ Antiporter NHX1 from Arabidopsis thaliana |
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Faunal remains from the Upper Paleolithic site of Nahal Rahaf 2 in the southern Judean Desert, Israel |
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Multi-contact statistics distinguish models of chromosome organization |
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Dendritic cell Piezo1 integrating mechanical stiffness and inflammatory signals directs the differentiation of TH1 and Treg cells in cancer |
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Myeloid cell evolution uncovered by shrimp immune cell analysis at single-cell resolution |
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Adaptation of bacterial proteome reveals a key role of the cell envelope in starvation survival |
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Single cell kinetic modeling of redox-based drug metabolism in head and neck squamous cell carcinoma |
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Maize immune signalling peptide ZIP1 evolved de novo from a retrotransposon |
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A conserved enzyme of smut fungi facilitates cell-to-cell movement in the plant bundle sheath |
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stainlib: a python library for augmentation and normalization of histopathology H&E images |
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Comprehensive and standardized benchmarking of deep learning architectures for basecalling nanopore sequencing data |
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Comparative genomics of five Valsa species gives insights on their pathogenicity evolution |
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ERnet: a tool for the semantic segmentation and quantitative analysis of endoplasmic reticulum topology for video-rate super-resolution imaging |
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Genome dynamics in mosses: Extensive synteny coexists with a highly dynamic gene space |
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Long-term adaptation to galactose as a sole carbon source selects for mutations in nutrient signaling pathways |
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Skewness in bee and flower phenological distributions |
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The Necrosis- and Ethylene-inducing peptide 1-like protein (NLP) gene family of the plant pathogen Corynespora cassiicola |
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The Clinical Response of Upadacitinib and Risankizumab is Associated with Reduced Inflammatory Bowel Disease Anti-TNFα Inadequate Response Mechanisms |
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A deeply conserved protease, acylamino acid-releasing enzyme (AARE), acts in plant aging |
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SARS-CoV-2 Subunit Virus-Like Vaccine Demonstrates High Safety Profile and Protective Efficacy: Preclinical Study |
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Radiation-Induced Metabolic Reprogramming of Fibroblasts Regulates the Breast Cancer Microenvironment |
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Substrate adhesion determines migration during mesenchymal cell condensation in chondrogenesis |
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Using unsupervised learning algorithms to identify essential genes associated with SARS-CoV-2 as potential therapeutic targets for COVID-19 |
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Adaptation-proof SARS-CoV-2 vaccine design |
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Immunomodulatory Extracellular Matrix Hydrogel Mitigates Scar Formation in a Model of Tongue Fibrosis. |
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SARS-CoV-2 ORF1abA1061S potentiate autoreactive T cell responses via epitope mimicry: an explanation to hepatitis of unknown cause |
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Molecular analysis of a public cross-neutralizing antibody response to SARS-CoV-2 |
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Machine Learning Reveals The Effect of Maternal Age on The Mouse Pre-Implantation Embryo Developmental Timing |
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Parallel measurement of transcriptomes and proteomes from same single cells using nanodroplet splitting |
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Thermopriming-associated proteome and sugar content responses in Pinus radiata embryogenic tissue |
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Selenocysteine metabolism is a targetable vulnerability in MYCN-amplified cancers |
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Menin-MLL Inhibitor MI-503 Blocks Menin Nuclear Export and Suppresses Hypergastrinemia |
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Interplay between cell height variations and planar pulsations in epithelial monolayers |
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Striosomes constrain locomotor vigor with respect to an innate valence differential |
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Visual experience has opposing influences on the quality of stimulus representation in adult primary visual cortex |
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The vestibular calyceal junction is dismantled in response to diverse injuring stimuli in rats and humans |
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Inferring Neural Activity Before Plasticity: A Foundation for Learning Beyond Backpropagation |
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Improvement of sensory deficits in Fragile X mice by increasing cortical interneuron activity after the critical period |
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Maintaining a stable head direction representation in naturalistic visual environments |
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A neural theory for counting memories |
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Short-term monocular deprivation boosts neural responsiveness to audio-visual events for the undeprived eye |
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Intermittent systemic exposure to lipopolysaccharide-induced inflammation disrupts hippocampal long-term potentiation and impairs cognition in aging male mice |
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Benefits of global mutant huntingtin lowering diminish over time in a Huntington's disease mouse model |
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Botrytis cinerea infection accelerates ripening and cell wall disassembly to promote disease in tomato fruit |
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Interactive Neurorobotics: Behavioral and Neural Dynamics of Agent Interactions |
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Modulation of Spindle Assembly Checkpoint efficiency by cell fate in a chordate embryo |
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Tracking and perceiving diverse motion signals: Directional biases in human smooth pursuit and perception |
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Late-onset glaucoma in Yap conditional knockout mouse |
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Simulation of the effect of the randomness of climbing fiber input on the relationship between motor learning and Focal Task-Specific Dystonia |
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Evolution of a Plastic Surgery Summer Research Program |
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3D-multiple immunoimaging using whole male organs in rice |
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Integration of multi-omics data shows downregulation of mismatch repair, purin, and tublin pathways in AR-negative triple-negative chemotherapy-resistant breast tumors |
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A comprehensive investigation of statistical and machine learning approaches for predicting complex human diseases on genomic variants |
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Detecting cell type from single cell RNA sequencing based on deep bi-stochastic graph regularized matrix factorization |
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A high-throughput test of anxiety for zebrafish (Danio rerio) larvae: the larval diving response (LDR) |
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Adaptation to ER-stress via serine glycine metabolism licences STING signalling and CMV control in intestinal epithelial cells |
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Therapeutic neutralizing monoclonal antibody administration protects against lethal viscerotropic Yellow Fever infection |
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TOB is an effector of the hippocampus-mediated acute stress response |
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Ptr1 and ZAR1 immune receptors confer overlapping and distinct bacterial pathogen effector specificities |
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The gradient-based parameter optimization to determine membrane ionic current composition of human induced pluripotent stem cell-derived cardiomyocytes |
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Evaluation of the DBA/2J mouse as a potential background strain for genetic models of cardiomyopathy |
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MFGE8 links absorption of dietary fatty acids with catabolism of enterocyte lipid stores through HNF4 γ- dependent transcription of CES enzymes |
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Two snakebite antivenoms have potential to reduce Eswatini's dependency upon a single, increasingly unavailable product: results of preclinical efficacy testing |
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Hippocampal β-adrenergic system modulates recognition memory reconsolidation |
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Quantifying Visual Acuity for Pre-Clinical Testing of Visual Prostheses. |
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Protective geometry and reproductive anatomy as candidate determinants of clutch size variation in pentatomid bugs |
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An algorithm for the identification of indicator taxonomic units and their use in analyses of ecosystem state |
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Alteration of Soil Bacteriome by Prolonged Exposure to Metal Oxide Nanoparticles |
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Re-direction of phagosomes to the recycling expulsion pathway by a fungal pathogen |
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Anthrax intoxication reveals that ER-Golgi membrane contact sites control the formation of plasma membrane lipid nanodomains |
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Inactivation of Vascular Stem Cells Suppresses Intimal Hyperplasia in Vein Grafts |
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Mindin differentially regulates fibroblast subpopulations via distinct members of the Src family kinases during fibrogenesis. |
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Actin limits egg aneuploidies associated with female reproductive aging. |
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High-fidelity optical diffraction tomography of live organisms using non-toxic tunable refractive index media |
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#PeerReview from @eLife of ???????? Human hippocampal responses to network stimulation vary with theta phase |
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#PeerReview from @ReviewCommons of ???????? Circadian regulation of the transcriptome in a complex polyploid crop |
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#PeerReview from @eLife of ???????? Spatial modeling reveals nuclear phosphorylation and subcellular shuttling of YAP upon drug-induced liver injury |
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#PeerReview from @eLife of ???????? Conditional Freezing, Flight and Darting? |
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#PeerReview from @eLife of ???????? Integration of computational modeling and quantitative cell physiology reveals central parameters for the brassinosteroid-regulated elongation growth along the axis of the Arabidopsis root |
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#PeerReview from @eLife of ???????? Homotopic contralesional excitation suppresses spontaneous circuit repair and global network reconnections following ischemic stroke |
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#PeerReview from @eLife of ???????? Recombinant single-cycle influenza virus as a new tool to augment antitumour immunity with immune checkpoint inhibitors |
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#PeerReview from @eLife of ???????? Network design principle for robust oscillatory behaviors with respect to biological noise |
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Long divergent haplotypes introgressed from wild sheep are associated with distinct morphological and adaptive characteristics in domestic sheep |
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Whole-brain computation of cognitive versus acoustic errors in music |
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The Proteomic Landscape of Genome-Wide Genetic Perturbations |
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Assessing PDB Macromolecular Crystal Structure Confidence at the Individual Amino Acid Residue Level |
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Simulating structurally variable Nuclear Pore Complexes for Microscopy |
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Single cell analysis reveals the molecular signaling and cellular composition of the regenerating Hydra head |
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Identifying novel regulators of placental development using time series transcriptomic data and network analyses |
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Transcription factors that specify cell fate activate cell cycle regulator genes to determine cell numbers in ascidian larval tissues |
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Zygotic genome activation by the totipotency pioneer factor Nr5a2 |
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The circadian clock mediates daily bursts of cell differentiation by periodically restricting cell differentiation commitment |
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Intracellular Calcium links Milk Stasis to Lysosome Dependent Cell Death during Mammary Gland Involution |
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Comparison of simple RNA extraction methods for molecular diagnosis of hepatitis C virus in plasma |
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Enterococcus faecalis and Staphylococcus aureus mixed species infection attenuates pathogen-specific neutrophil responses and impairs bacterial clearance |
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Investigating And Modeling the Factors that Effects the Performance of Genetic Circuits |
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Identification of Three Medically Important Mosquito Species Using Raman Spectroscopy |
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A structural basis for prion strain diversity |
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Nature-Inspired Chemical Probes for in-cell Labeling of Lipidized RNA and Identification of New Regulatory Enzymes |
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The evolution of fitness effects during long-term adaptation in bacteria |
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Activity of Tricyclic Pyrrolopyrimidine Gyrase B Inhibitor against Mycobacterium abscessus |
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Liver humanized NSG-PiZ mice support the study of chronic hepatitis B virus infection and antiviral therapies |
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Zidovudine multi-combos with last-line fosfomycin, ceftazidime-avibactam, colistin and tigecycline against Multi-Drug Resistant Klebsiella pneumoniae |
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Enhanced flavour profiles through radicicol induced genomic variation in S. pastorianus lager yeast |
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Proteins released into the plant apoplast by the obligate parasitic protist Albugo selectively repress phyllosphere-associated bacteria |
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All Staphylococcus aureus bacteraemia strains have the potential to cause infective endocarditis: results of GWAS and experimental animal studies |
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Structure Activity Relationship of the Stem Peptide in Sortase A mediated Ligation from Staphylococcus aureus |
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Leishmania infection-derived extracellular vesicles drive transcription of genes involved in M2 polarization. |
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Lipopolysaccharide-mediated resistance to host antimicrobial peptides and hemocyte-derived reactive-oxygen species are the major Providencia alcalifaciens virulence factors in Drosophila melanogaster |
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X-ray imaging of 30 year old wine grape wood reveals cumulative impacts of rootstocks on scion secondary growth and harvest index |
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Functional regulation of 4D metabolic network between multienzyme glucosome condensates and mitochondria |
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Simulations of Pathogenic E1α Variants: Allostery and Impact on Pyruvate Dehydrogenase Complex-E1 Structure and Function |
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D-2-Hydroxyglutarate dehydrogenase connects the propionate shunt to ketone body metabolism in Caenorhabditis elegans |
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Cryo-EM structure of the agonist-bound Hsp90-XAP2-AHR complex |
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Serine Racemase is a Cysteine Racemase and Physiologic Down Regulator of Insulin Promoter Methylation |
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Clonally selected lines after CRISPR/Cas editing are not isogenic |
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Parallel changes in gene essentiality over 50,000 generations of evolution |
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RNA sequence to structure analysis from comprehensive pairwise mutagenesis of multiple self-cleaving ribozymes |
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CRISPR/Cas9-Mediated Excision of ALS/FTD-Causing Hexanucleotide Repeat Expansion in C9ORF72 rescues major disease mechanisms in vivo and in vitro |
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Spontaneous genomic variation as a survival strategy of nosocomial S. haemolyticus |
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Pig manure treatment strategies for mitigating the spread of antibiotic resistance |
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Anaerobic degradation of acid red 73 by obligately aerobic Aspergillus tabacinus LZ-M though a self-redox mechanism |
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In-vivo detection of cyclic-di-AMP in Staphylococcus aureus |
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Reemergence of the Murine Bacterial Pathogen Chlamydia muridarum in Laboratory Mouse Colonies |
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Enhancement of Cell Adhesion by Anaplasma phagocytophilum Nucleolin-interacting Protein AFAP |
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The ATLAS™ screening assay reveals distinct CD4+ and CD8+ SARS-CoV-2 antigen response profiles which have implications to Omicron cellular immunity |
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A study of a diauxic growth experiment using an expanded dynamic flux balance framework |
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Mathematical Characterization of Private and Public Immune Repertoire Sequences |
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Machine Learning Predicts Treatment Response in Bipolar & Major Depressive Disorders |
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Maturation kinetics of phagosomes depends on their transport switching from actin to microtubule tracks |
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A curated human cellular microRNAome based on 196 primary cell types |
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A unified urban green infrastructure classification for assessing ecosystem services and biodiversity |
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Phage resistance profiling identifies new genes required for biogenesis and modification of the corynebacterial cell envelope |
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Retina Gap Junction Networks Facilitate Blind Denoising in Visual Hierarchy |
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Network Topology Metrics Explaining Enrichment of Hybrid Epithelial Mesenchymal Phenotypes in Metastasis |
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Enzymatically-active bacterial microcompartments follow substrate gradients and are protected from aggregation in a cell-free system |
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In-Vitro Efficacy of Targeted FODMAP Enzymatic Digestion in a High-Fidelity Simulated Gastrointestinal Environment |
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Structural disruption of BAF chromatin remodeller impairs neuroblastoma metastasis by reverting an invasiveness epigenomic program |
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Targeting advanced prostate cancer with STEAP1 chimeric antigen receptor T cell therapy |
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Rabphilin 3A binds the N-peptide of SNAP-25 to promote SNARE complex assembly in exocytosis |
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Topology Adaptive Graph Convolution Network With Heterogeneous Entities For Predicting Adverse Events from Drug-Drug-Interactions |
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Evaluating trait-based sets for taxonomic enrichment analysis applied to human microbiome data sets |
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De Novo Protein Fold Design Through Sequence-Independent Fragment Assembly Simulations |
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Choice of 3D morphometric method leads to diverging interpretations of form--function relationships in the carnivoran calcaneus |
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From first principles to structure and function of unicellular plankton communities |
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Quantitative analysis of three-dimensional cell organisation and concentration profiles within curved epithelial tissues |
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Post-transcriptional control of SRSF9 promotes the epithelial-to-mesenchymal transition (EMT) in colorectal cancer cells |
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PRR14 organizes H3K9me3-modifed heterochromatin at the nuclear lamina |
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Variation in the ACE2 receptor has limited utility for SARS-CoV-2 host prediction |
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A kinetic basis for curvature sensing by septins |
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Predicting 3D RNA structure from solely the nucleotide sequence using Euclidean distance neural networks |
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Unsupervised outlier detection applied to SARS-CoV-2 nucleotide sequences can identify sequences of common variants and other variants of interest |
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YAP promotes cell-autonomous immune responses to tackle intracellular Staphylococcus aureus in vitro |
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CD133+ Intercellsome Mediates Direct Cell-Cell Communication to Offset Intracellular Signaling Deficit |
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CHIP ubiquitin ligase is involved in the nucleolar stress management |
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Membrane stretching activates calcium-permeability of putative fission yeast Pkd2 channel |
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Kynurenic acid, a key L-tryptophan-derived metabolite, protects the heart from an ischemic damage |
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Differential Evasion of Delta and Omicron Immunity and Enhanced Fusogenicity of SARS-CoV-2 Omicron BA.4/5 and BA.2.12.1 Subvariants |
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Prophylactic treatment of Glycyrrhiza glabra mitigates COVID-19 pathology through inhibition of pro-inflammatory cytokines in the hamster model and NETosis. |
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SARS-CoV-2 accessory proteins ORF7a and ORF3a use distinct mechanisms to downregulate MHC-I surface expression |
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Assessment of 3D MINFLUX data for quantitative structural biology in cells revisited |
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Primary cilia regulate Meibomian glands development and dimensions without impairing the lipid composition of the meibum |
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Pathogenic TDP-43 Disrupts Axon Initial Segment Structure and Neuronal Excitability in a Human iPSC Model of ALS |
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Cachd1 is a novel Frizzled- and LRP6-interacting protein required for neurons to acquire left-right asymmetric character |
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An automated high-content synaptic phenotyping platform in human neurons and astrocytes reveals a role for BET proteins in synapse assembly |
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Action initiation and punishment learning differ from childhood to adolescence while reward learning remains stable |
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Brain-wide imaging of an adult vertebrate with image transfer oblique plane microscopy |
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MAGScoT - a fast, lightweight, and accurate bin-refinement software |
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Highly efficient genome editing in barley using novel LbCas12a variants and impact of sgRNA architecture |
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Chromosome-level Reference Genome Provides Insights into Divergence and Stress Adaptation of the African Oil Palm |
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MaLAdapt reveals novel targets of adaptive introgression from Neanderthals and Denisovans in worldwide human populations |
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Evidence for correlated Eeolution of sexual selection and pseudogenization in primate fertilization |
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#PeerReview from @eLife of ???????? Cortical adaptation to sound reverberation |
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#PeerReview from @eLife of ???????? Ancestral reconstruction of duplicated signaling proteins reveals the evolution of signaling specificity |
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#PeerReview from @eLife of ???????? Motor processivity and speed determine structure and dynamics of microtubule-motor assemblies |
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Near-chromosomal de novo assembly of Bengal tiger genome reveals genetic hallmarks of apex-predation |
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A CRISPR-screen in intestinal epithelial cells identifies novel factors for polarity and apical transport |
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A new paradigm for personal protection against ticks: efficacy of spatial repellents to reduce host seeking activities in three major tick species of medical importance |
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Toxic effects of elevated bile acid levels on fetal myocardium in intrahepatic cholestasis of pregnancy?from a neonatal perspective |
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#PeerReview from @ReviewCommons of ???????? TORC1, BORC, and ARL-8 cycling drive vesiculation of cell corpse phagolysosomes |
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3D Chromatin Structure in Chondrocytes Identifies Putative Osteoarthritis Risk Genes |
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Developmentally determined intersectional genetic strategies to dissect adult somatosensory circuit function |
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Carbon footprint of South Dakota dairy production system and assessment of mitigation options |
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AT-hook DNA-binding motif-containing protein one knockdown downregulates EWS-FLI1 transcriptional activity in Ewings sarcoma cells |
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Aspergillus fumigatus can exhibit persistence to the fungicidal drug voriconazole |
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#PeerReview from @eLife of ???????? A pulse-chasable reporter processing assay for mammalian autophagic flux with HaloTag |
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#PeerReview from @eLife of ???????? Drosophila gustatory projections are segregated by taste modality and connectivity |
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#PeerReview from @eLife of ???????? Magnetic Stimulation Allows Focal Activation of the Mouse Cochlea |
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#PeerReview from @eLife of ???????? Anatomical connectivity along the anterior-posterior axis of the human hippocampus: new insights using quantitative fibre-tracking. |
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#PeerReview from @eLife of ???????? Conserved structural elements specialize ATAD1 as a membrane protein extraction machine |
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#PeerReview from @eLife of ???????? Timely sleep coupling: spindle-slow wave synchrony is linked to early amyloid-β burden and predicts memory decline |
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#PeerReview from @eLife of ???????? Non-cancer stem cell-derived Fibromodulin activates Integrin-dependent Notch signaling in endothelial cells to promote tumor angiogenesis and growth |
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#PeerReview from @eLife of ???????? Unleashing a Novel Function of Endonuclease G in Mitochondrial Genome Instability |
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#PeerReview from @eLife of ???????? Lung evolution in vertebrates and the water-to-land transition |
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#PeerReview from @eLife of ???????? Niche-specific genome degradation and convergent evolution shaping Staphylococcus aureus adaptation during severe infections |
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#PeerReview from @eLife of ???????? Self-organization of in vitro neuronal assemblies drives to complex network topology |
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#PeerReview from @eLife of ???????? The rapid developmental rise of somatic inhibition disengages hippocampal dynamics from self-motion |
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#PeerReview from @eLife of ???????? Contribution of behavioural variability to representational drift |
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#PeerReview from @eLife of ???????? Alveolar regeneration following viral infection is independent of tuft cells |
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Isolation of bat sarbecoviruses of SARS-CoV-2 clade, Japan |
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Functional evolution of SARS-COV-2 Spike protein: adaptation on translation and infection via surface charge of spike protein |
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Extensive lineage-specific rediploidisation masks shared whole genome duplication in the sturgeon-paddlefish ancestor |
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Human Surfactant Protein D Facilitates SARS-CoV-2 Pseudotype Binding and Entry in DC-SIGN Expressing Cells, and Downregulates Spike protein Induced Inflammation |
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Imaging unlabeled axons in the mouse retina by second harmonic generation |
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Two independent loss-of-function mutations in anthocyanidin synthase homeologous genes make sweet basil all green |
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Visual system hyperexcitability and compromised V1 receptive field properties in early-stage retinitis pigmentosa in mice |
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Mammary Tissue-Derived Extracellular Matrix Hydrogels Reveal the Role of the Irradiated Microenvironment in Breast Cancer Recurrence |
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Engineered Riboswitch Nano-carriers as a Possible Disease-Modifying Treatment for Metabolic Disorders |
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Information integration for nutritional decision-making in desert locusts |
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Detailed investigation on the role of lipid metabolizing enzymes in the pathogenesis of retinopathy of prematurity among preterm infants. |
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Knockouts of positive and negative elements of the circadian clock disrupt photoperiodic diapause induction in the silkworm, Bombyx mori |
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Does sexual conflict contribute to the evolution of novel warning patterns? |
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Developing a predictive model for an emerging epidemic on cassava in sub-Saharan Africa |
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Sex differences in coronary artery disease and diabetes revealed by scRNA-Seq and CITE-Seq of human CD4+ T cells |
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cGAS/STING-DEPENDENT SENSING OF ENDOGENOUS RNA |
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Quantifying rhythmicity in perceptual reports |
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From recency to the central tendency bias in working memory: a unifying attractor network model |
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Channel-independent function of UNC-9/INX in spatial arrangement of GABAergic synapses in C. elegans |
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The time course of categorical and perceptual similarity effects in visual search |
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Decoding Individual Differences in Mental Information from Human Brain Response Predicted by Convolutional Neural Networks |
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Coexistence of Cue-specific and Cue-independent Spatial Representations for Landmarks and Self-motion Cues in Human Retrosplenial Cortex |
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The history and organization of the Workshop on Population and Speciation Genomics |
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Plyometric training enhances strength and precision of the finger movements in pianists |
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A key role of the WEE1-CDK1 axis in mediating TKI-therapy resistance in FLT3-ITD positive acute myeloid leukemia patients |
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3D-surface reconstruction of cellular cryo-soft X-ray microscopy tomograms using semi-supervised deep learning |
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JBrowse Jupyter: A Python interface to JBrowse 2 |
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Comprehensive machine-learning survival framework develop a consensus model in large scale multi-center cohorts for pancreatic cancer |
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The Limits of Molecular Signatures for Pancreatic Ductal Adenocarcinoma Subtyping |
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Ants act as olfactory bio-detectors of tumour in patient-derived xenograft mice |
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Improved SpCas9 and LbCas12a genome editing systems in Brassica oleracea and Brassica napus |
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Combined reference-free and multi-reference approaches uncover cryptic variation underlying rapid adaptation in microbial pathogens |
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nnSVG: scalable identification of spatially variable genes using nearest-neighbor Gaussian processes |
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Genome-wide data from medieval German Jews show that the Ashkenazi founder event pre-dated the 14th century |
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Genomic and bioclimatic diversity of Ethiopian barley (Hordeum vulgare L.) landraces reveals vulnerability to climate change |
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Multiplexed chromatin imaging reveals predominantly pairwise long-range coordination between Drosophila Polycomb genes |
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The origin and evolution of mitochondrial tropism in Midichloria bacteria |
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Insertions and deletions mediated functional divergence of Rossmann fold enzymes |
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Area of Habitat maps for the world's terrestrial birds and mammals |
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Foxe1 orchestrates thyroid and lung cell lineage divergence in mouse stem cell-derived organoids |
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Composition can buffer protein dynamics within liquid-like condensates. |
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Parallel clonal and molecular profiling of hematopoietic stem cells using RNA barcoding |
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In vitro and in vivo gene introduction in the cloudy catshark (Scyliorhinus torazame), a cartilaginous fish |
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Terminal differentiation and persistence of effector regulatory T cells essential for the prevention of intestinal inflammation |
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Neuroinflammation in neuronopathic Gaucher disease: Role of microglia and NK cells |
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Sensorimotor decisions rely on the entanglement of evidence and motor accumulation processes |
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Integration of sound and locomotion information by auditory cortical neuronal ensembles |
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Identification of differentially expressed novel tau associated proteins in transgenic AD model of Drosophila - a proteomic and in silico Approach |
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Focal electrical stimulation on an alcohol disorder model using MRI-compatible chronic neural monopolar carbon fiber electrodes. |
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Peripheral sensory neuron CB2 cannabinoid receptors are necessary for both CB2-mediated antinociceptive efficacy and sparing of morphine tolerance in a mouse model of neuropathic pain |
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Shelf-Life Specific Moisture Variation In Chitosan Of Genus Fenneropenaeus Distributed Along Arabian Sea, India |
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Shedding Light on functional Near Infrared Spectroscopy and Open Science Practices |
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CITE-Viz: Replicating the Interactive Flow Cytometry Workflow in CITE-Seq |
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Recalibrating the cerebellum DNA methylation clock: implications for ageing rates comparison |
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Ultrastructure Expansion Microscopy reveals the nanoscale cellular architecture of budding and fission yeast |
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No evidence for detectable direct effects of magnetic field on cellular autofluorescence |
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Novel synergistic combinations of last-line antibiotics and FDA-approved drugs against Klebsiella pneumoniae revealed by in vitro synergy screenings |
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Unique gut microbiome signatures among adult patients with moderate to severe atopic dermatitis in southern Chinese |
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Modification-Dependent Restriction Endonuclease-based sequencing method (EcoWI-seq) maps the genome-wide landscape of phosphorothioate modification at base resolution. |
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Sterol side chain alkylation by sponge and bacterial methyltransferases |
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Design and construction of 3D-printed devices to investigate active and passive bacterial dispersal on hydrated surfaces |
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Allosteric inactivation of an engineered optogenetic GTPase |
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On the interplay between lipids and asymmetric dynamics of an NBS degenerate ABC transporter |
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Juxtaposition of Bub1 and Cdc20 on phosphorylated Mad1 during catalytic mitotic checkpoint complex assembly |
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A SCID mouse model to evaluate the efficacy of antivirals against SARS-CoV-2 infection |
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Single molecule analyses of Salmonella translocated effector proteins reveal targeting to and dynamics in host cell endomembranes |
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A live attenuated vaccine confers superior mucosal and systemic immunity to SARS-CoV-2 variants |
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AI-based search for convergently expanding, advantageous mutations in SARS-CoV-2 by focusing on oligonucleotide frequencies |
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SARS-CoV-2 Omicron Variant Wave in India: Advent, Phylogeny and Evolution |
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The L1 Cell Adhesion Molecule Constrains Dendritic Spine Density through Ankyrin Binding in Pyramidal Neurons of the Mouse Cerebral Cortex |
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Gray Matter Volumetric Correlates of Attention Deficit and Hyperactivity Traits in Emerging Adolescents |
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Expanding EMC Foldopathies: Topogenesis Deficits Alter the Neural Crest |
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Infection of the maternal-fetal interface and vertical transmission following low-dose inoculation of pregnant rhesus macaques (Macaca mulatta) with an African-lineage Zika virus |
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Insights into plastic biodegradation: community composition and functional capabilities of the superworm (Zophobas morio) microbiome in styrofoam feeding trials |
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The spatiotemporal dynamics of recognition memory for complex versus simple auditory sequences |
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Optimal balancing of xylem efficiency and safety explains plant vulnerability to drought |
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Mannose metabolism inhibition sensitizes acute myeloid leukemia cells to cytarabine and FLT3 inhibitor therapy by modulating fatty acid metabolism to drive ferroptotic cell death. |
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Dynamic allostery in substrate binding by human thymidylate synthase |
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Feature Importance Network reveals novel functional relationships between biological features in Arabidopsis thaliana |
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A systematic evaluation of deep learning methods for the prediction of drug synergy in cancer |
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Adaptive diversification and niche packing on rugged fitness landscapes |
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Genomic insights into the adaptive and convergent evolution of Leuciscus waleckii inhabiting extremely alkaline environments |
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Cheaters among pollinators: Floral traits drive spatiotemporal variation in nectar robbing and thieving in Afrotropical rainforests |
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Rare Gli1+ perivascular fibroblasts promote skin wound repair |
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Adult Hox gene expression promotes periosteal stem cell maintenance and mediates reprogramming in a regionally restricted manner |
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The Vibrio cholerae Seventh Pandemic islands act in tandem to defend against a circulating phage |
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A Unified Catalog of 19,251 Non-human Reference Species Genomes Provides New Insights into the Mammalian Gut Microbiomes |
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Adaptive Immune Landscape of T-Cell Mediated Rejection of Human Kidney Allografts |
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Pathway and directional specificity of Hebbian plasticity induction in the cortical visual motion processing network |
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Altered Regulation of Ia Afferent Input during Voluntary Activity after Human Spinal Cord Injury |
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Trimethylamine N-oxide reduces neurite density and plaque intensity in a murine model of Alzheimer disease |
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Interneurons of fan-shaped body promote arousal in Drosophila |
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Arbuscular mycorrhizae reduce stress-induced plasticity of plant functional traits. A meta-analysis study |
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Oversharing by honey bees and the spread of viruses |
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Studying protein-protein interaction through side-chain modeling method OPUS-Mut |
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In vitro generation of human embryonic stem cell-derived heart organoids possessing physiological ion currents |
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Structural insights into bacterial sterol transport |
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Predicting the HER2 status in esophageal cancer from tissue microarrays using convolutional neural networks |
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Pairwise sequence similarity mapping with PaSiMap: reclassification of immunoglobulin domains from titin as case study |
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A potential Toxoplasma gondii lipoxygenase is necessary for virulence and associated with the host immune response |
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Nlrc4 inflammasome is critical for host protection against flagellated Salmonella |
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High-and Low-Frequency Deep Brain Stimulation in the Subthalamic Nucleus differentially modulate Response Inhibition and Action Selection in Parkinson's Disease |
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In situ cryo-electron tomography reveals the asymmetric architecture of mammalian sperm axonemes |
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Stable population structure in Europe since the Iron Age, despite high mobility |
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Linked selection and the evolution of altruism in a family-structured population |
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Evidence of divergent selection in a parasite due to its host immunological respond |
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Locus c{oelig}ruleus noradrenergic neurons phase-lock to prefrontal cortical and hippocampal infra-slow rhythms which synchronize with behavioral events |
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Morphogen gradient orchestrates pattern-preserving tissue morphogenesis via motility-driven (un)jamming |
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Differential effect of Fas activation on spinal muscular atrophy motoneuron death and induction of axonal growth |
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De Novo RNA Tertiary Structure Prediction at Atomic Resolution Using Geometric Potentials from Deep Learning |
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MultiCens: Multilayer network centrality measures to uncover molecular mediators of tissue-tissue communication |
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Hecatomb: An End-to-End Research Platform for Viral Metagenomics |
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On the bacterial ancestry of mitochondria: new insights with triangulated approaches |
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Population genomics of a threespine stickleback tapeworm in Vancouver Island |
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Local adaptation and host specificity to copepod intermediate hosts by the Schistocephalus solidus tapeworm |
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Late Fetal and Newborn Granulopoiesis but not Active Renin is Increased by Maternal Captopril Treatment During Perinatal Kidney Development |
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Site-specific decreases in DNA methylation in replicating cells following exposure to oxidative stress |
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The Individualized Neural Tuning Model: Precise and generalizable cartography of functional architecture in individual brains |
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Onsager regression characterizes living systems in passive measurements |
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Concurrent spinal and brain imaging with optically pumped magnetometers |
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DNA binding domain undergoes dynamic and selective protein-protein interactions to facilitate CTCF insulation |
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MHC-II molecules present RhoC-derived peptides on the surface of tumour cells |
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Alignment of Single-Molecule Sequencing Reads by Enhancing the Accuracy and Efficiency of Locality-Sensitive Hashing |
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Evolution of personality and locomotory performance traits during a late Pleistocene island colonization in a treefrog |
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PAX4 loss of function alters human endocrine cell development and influences diabetes risk |
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Recapitulation of the embryonic transcriptional program in insect pupae |
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The proto-oncogene DEK regulates neuronal excitability and tau accumulation in Alzheimer's disease vulnerable neurons |
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Photoperiod and vernalization alleles and their combinations greatly affected phenological and agronomic traits in bread wheat under autumn and spring sowing conditions |
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Chromatin-modifying enzymes as modulators of nuclear size during lineage differentiation |
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Pan-cancer scale screening reveals NRF2 associated immunoevasive characteristics in non-small cell lung cancer and squamous malignancies |
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High-content cellular screen image analysis benchmark study |
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Open Access Repository-Scale Propagated Nearest Neighbor Suspect Spectral Library for Untargeted Metabolomics |
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Multifunctional flexible electro-optical arrays for simultaneous spatiotemporal cardiac mapping and modulation |
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Hepatic AMPK activation in response to dynamic REDOX balance is a biomarker of exercise to improve blood glucose control |
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Senolytic Treatment Reduces Cell Senescence and Necroptosis in Sod1 Knockout Mice that is Associated with Reduced Inflammation and Hepatocellular Carcinoma |
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The Drosophila attP40 docking site and derivatives are insertion mutations of MSP300 |
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Novel epidemiological model of gastrointestinal-nematode infection to assess grazing cattle resilience by integrating host growth, parasite, grass and environmental dynamics |
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Remote sensing tools for plant invasions assessment in native tropical forests of a volcanic island |
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Detection of Borrelia garinii in the USA |
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Melanogenic Activity Facilitates plasmacytoid Dendritic Cell Maturation |
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The canonical HPA axis contributes to locomotion during photoadaptation but is not required |
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Category representations in the primary visual cortex support orientation discrimination |
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Disrupted Decision-Making: EcoHIV Inoculation Following a History of Cocaine Use |
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Identifying the Neural Correlates of Balance Deficits in Traumatic Brain Injury using the Partial Least Squares Correlation (PLSC) analysis |
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Generating parallel representations of position and identity in the olfactory system |
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Negative emotional behavior during fentanyl abstinence is mediated by adaptations in nucleus accumbens neuron subtypes |
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A machine learning approach for automatic sleep staging using heart rate variability |
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An algorithmic framework for isoform-specific functional analysis |
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PleistoDist: A toolbox for visualising and quantifying the effects of Pleistocene sea-level change on island archipelagos |
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Identification of representative trees in random forests based on a new tree-based distance measure |
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Integration of gene expression data in Bayesian association analysis of rare variants |
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Topological analysis of brain dynamics in autism based on graph and persistent homology |
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Intermittent fasting mitigates cognitive deficits in Alzheimer's disease via the gut-brain axis |
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The lncRNA Firre functions as a transcriptional activator from a distance |
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Environmental selection, rather than neutral processes, best explain patterns of diversity in a tropical rainforest fish |
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The nerodevelopmental genes alan shepard and Neuroglian are spatially structured in an admixed population and contribute to female mate preference |
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Ecological Drivers of Community Cohesion |
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Generation of a human ovarian granulosa cell model from induced pluripotent stem cells |
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Active licking shapes cortical taste coding. |
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Prediction of Stroke Outcome in Mice Based on Non-Invasive MRI and Behavioral Testing |
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#PeerReview from @eLife of ???????? Nanoscale resolution of microbial fiber degradation in action |
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Identification by cryoEM of a densovirus causing mass mortality in mass-reared larval darkling beetles (Zophobas morio) |
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#PeerReview from @eLife of ???????? A dual-target herbicidal inhibitor of lysine biosynthesis |
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#PeerReview from @eLife of ???????? GENESPACE: syntenic pan-genome annotations for eukaryotes |
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#PeerReview from @BiophysicsColab of ???????? Combinatorial G x G x E CRISPR screening and functional analysis highlights SLC25A39 in mitochondrial GSH transport |
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Structural-guided fragment-based drug discovery applied to antitoxin, MAB3862 opens a new possibility of exploring the Toxin and Antitoxin for antibiotics. |
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The ClpP Peptidase Forcefully Grips Protein Substrates |
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Solubility-aware protein binding peptide design using AlphaFold |
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Cysteine Restriction-Specific Effects of Sulfur Amino Acid Restriction on Lipid Metabolism |
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Activity-based CRISPR Scanning Uncovers Allostery in DNA Methylation Maintenance Machinery |
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Protein painting reveals pervasive remodeling of conserved proteostasis machinery in response to pharmacological stimuli. |
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Diverse RNA viruses associated with diatom, eustigmatophyte, dinoflagellate and rhodophyte microalgae cultures |
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More accurate estimation of cell composition in bulk expression through robust integration of single-cell information |
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Human REM sleep controls neural excitability in support of memory formation |
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Genes ruler for genomes, Gnodes, measures assembly accuracy in animals and plants |
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Quantifying the adaptive landscape of commensal gut bacteria using high-resolution lineage tracking |
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Evolution of reading and face circuits during the first three years of reading acquisition |
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Medial temporal lobe structure, mnemonic and perceptual discrimination in healthy older adults and those at risk for mild cognitive impairment |
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Flexing the principal gradient of the cerebral cortex to suit changing semantic task demands |
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Wild-type IDH1 inhibition enhances chemotherapy response in melanoma |
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NMR as a readout to monitor and restore the integrity of complex chemoenzymatic reactions |
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Bioengineering multifunctional extracellular vesicles for targeted delivery of biologics to T cells |
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Time series transcriptome analysis uncovers regulatory networks and a role for the circadian clock in the Drosophila melanogaster female's response to Sex Peptide |
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Endoplasmic Reticulum membranes are continuously required to maintain mitotic spindle size and forces |
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Picking winners in cell-cell collisions: wetting, speed, and contact |
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The Scar/WAVE complex drives normal actin protrusions without the Arp2/3 complex, but proline-rich domains are required |
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Intrinsic RNA targeting constrains the utility of CRISPR-Cas13 systems |
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Detecting apoptosis via DODO |
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First report of classical knockdown resistance (kdr) mutation, L1014F, in human head louse Pediculus humanus capitis (Phthiraptera: Anoplura) |
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An atrial fibrillation-associated regulatory region modulates cardiac Tbx5 levels and arrhythmia susceptibility |
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A toxin-mediated policing system in Bacillus improves population fitness via penalizing non-cooperating phenotypic cheaters |
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Adding a new dimension: Multi-level structure and organization of mixed-species Pseudomonas aeruginosa and Staphylococcus aureus biofilms in a 4-D wound microenvironment |
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Melanocyte-secreted Fibromodulin constrains skin inflammation in mice injected with lupus serum |
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The Influences of Stomatal Size and Density on Rice Drought, Salinity and VPD Resilience |
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KDM4A promotes NEPC progression through regulation of MYC expression |
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Exogenous DNA upregulates DUOX2 expression and function in human pancreatic cancer cells by activating the cGAS-STING signaling pathway |
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Conformational fluctuations in molten globule state of α-lactalbumin |
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Hydroxylation site-specific and production-dependent roles of endogenous oxysterols in cellular cholesterol homeostasis |
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pH-responsive self-assembled compartments as tuneable model protocellular membrane systems |
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Transnational non-invasive monitoring and spatial capture-recapture models reveal strong effects of humans on connectivity for the Pyrenean brown bear |
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Site pleiotropy of a stickleback tooth and fin enhancer |
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TGFβ treatment alters the scleral fibroblast migratory response to cyclic strain in an ERK-dependent manner |
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Surface-Induced cAMP Signaling Requires Multiple Features of the Pseudomonas aeruginosa Type IV Pili |
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Parvimonas micra, an oral pathobiont associated with colorectal cancer, epigenetically reprograms human primary intestinal epithelial cells |
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Regulation of Chlamydia RsbU phosphatase activity by the enolase product, phosphoenolpyruvate |
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tRNA Methylation Resolves Codon Usage Bias at the Limit of Cell Viability |
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Nanoparticle-induced augmentation of neutrophils' phagocytosis of bacteria |
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Distinct population and single-neuron selectivity for executive and episodic processing in human dorsal posterior cingulate |
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Status epilepticus induces chronic silencing of burster and dominance of regular firing neurons during sharp wave-ripples in the mouse subiculum |
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Doublecortin-like kinase 1 (DCLK1) Facilitates Dendritic Spine Growth of Pyramidal Neurons in Mouse Prefrontal Cortex |
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Asymmetric Signaling Across the Hierarchy of Cytoarchitecture within the Human Connectome |
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Kidney collecting duct cells make vasopressin in response to NaCl induced hypertonicity |
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Modelling the structure of Short Gastrulation and generation of a toolkit for studying its function in Drosophila |
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Synonymous codon usage regulates translation initiation |
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Monozygotic twins discordant for schizophrenia differ in maturation and synaptic transmission |
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A gain-of-function recurrent missense variant leads to a GABAergic/glutamatergic imbalance in a forebrain organoid model of PACS1 syndrome |
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The 5-LOX/COX-2 cross-over metabolite, hemiketal E2, enhances VEGFR2 activation and promotes angiogenesis |
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MYC Overexpression Drives Immune Evasion in Human Cancer that is Reversible Through Restoration of Pro-Inflammatory Macrophages |
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Accurate Identification of Extrachromosomal Circular DNA from Long-read Sequences. |
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Polycomb proteins translate histone methylation to chromatin folding |
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Miro GTPase domains regulate assembly of the mitochondrial motor-adaptor complex |
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Moderate ART resistance mutations with low fitness cost in malaria parasites from Africa |
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CvkR, a novel MerR-type transcriptional regulator, is a repressor of class 2 type V-K CRISPR-associated transposase systems |
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Reversal of splicing infidelity is a pre-activation step in B cell differentiation |
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Borrelia burgdorferi engages mammalian type I interferon responses via the cGAS-STING pathway |
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Blockade of TGF-β signaling reactivates HIV-1/SIV reservoirs and immune responses in vivo |
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Arabidopsis thaliana rosette growth habit is a photomorphogenic trait controlled by the TALE homeodomain protein ATH1 and involves TOR kinase |
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Identification of Fusarium Head Blight resistance in Triticum timopheevii accessions and characterisation of wheat-T. timopheevii introgression lines for enhanced resistance. |
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Female factors are important for the seminal Sex Peptide's association with sperm in mated female D. melanogaster. |
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Structural Basis of Mutation-Dependent p53 Tetramerization Deficiency |
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Single-cell characterisation of the hematopoietic bone marrow interactome in health and disease |
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An atlas of epithelial cell states and plasticity in lung adenocarcinoma |
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C-terminal determinants for RNA binding motif 7 protein stability and RNA recognition |
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Structural basis of Yta7 ATPase-mediated nucleosome disassembly |
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Arf GTPase activates the WAVE Regulatory Complex through a novel binding site |
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#PeerReview from @eLife of ???????? Collective dynamics support group drumming, reduce variability, and stabilize tempo drift |
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#PeerReview from @eLife of ???????? Gene Expression and Tracer-Based Metabolic Flux Analysis Reveals Tissue-Specific Metabolic Scaling in vitro, ex vivo, and in vivo |
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#PeerReview from @eLife of ???????? A generalized cortical activity pattern at internally-generated mental context boundaries during unguided narrative recall |
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#PeerReview from @eLife of ???????? SRSF10 is essential for progenitor spermatogonia expansion by regulating alternative splicing |
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#PeerReview from @eLife of ???????? DIP2 is a unique regulator of diacylglycerol lipid homeostasis in eukaryotes |
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#PeerReview from @eLife of ???????? A single exposure to altered auditory feedback causes observable sensorimotor adaptation in speech |
2021-07-26 |
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#PeerReview from @eLife of ???????? Altered excitatory and inhibitory neuronal subpopulation parameters are distinctly associated with tau and amyloid in Alzheimer's disease |
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Predictive Models of Genome-wide Aryl Hydrocarbon Receptor DNA Binding Reveal Tissue Specific Binding Determinants |
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VAP-A intrinsically disordered regions enable versatile tethering at membrane contact sites |
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Vitamin K-dependent carboxylation of junctate regulates calcium flux and adaptation to metabolic stress in β-cells |
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Porous marine snow differentially benefits chemotactic, motile, and non-motile bacteria |
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Development of 3D bovine intestinal organoid derived models to investigate Mycobacterium avium ssp paratuberculosis pathogenesis |
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Agency as a Bridge to Form Associative Memories |
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High-resolution kinetic gene expression analysis of T helper cell differentiation reveals a STAT-dependent, unique transcriptional program in Th1/2 hybrid cells |
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Changes of oscillatory and aperiodic neuronal activity in working memory following anaesthesia: a prospective observational study |
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Interpretable machine learning of action potential duration restitution kinetics in single-cell models of atrial cardiomyocytes |
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Selective observation of semi-rigid residues on the surface of dynamically complex mutant huntingtin protein fibrils |
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Modelling human and non-human animal network data in R using STRAND |
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Analysis of the contribution of intrinsic disorder in shaping potyvirus genetic diversity |
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Mycorrhizas shape the evolution of plant adaptation to drought |
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Blind spots on western blots: a meta-research study highlighting opportunities to improve figures and methods reporting |
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Short term tomato consumption alters the pig gut microbiome towards a more favorable profile |
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Structural insights for neutralization of BA.1 and BA.2 Omicron variants by a broadly neutralizing SARS-CoV-2 antibody |
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Post-transcriptional regulatory feedback encodes JAK-STAT signal memory of interferon stimulation |
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Efficient parameter calibration and real-time simulation of large scale spiking neural networks with GeNN and NEST |
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Comparative Transcriptome Analysis of Hypocotyls During the Developmental Transition of C3 cotyledons to C4 Leaves in Halimocnemis mollissima: Exploring Root-Shoot Signalings Involved in the Establishing of C4 traits |
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Single Particle Tracking With Compressive Sensing Using Progressive Refinement Method On Sparse Recovery (spt-PRIS) |
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The Smc5/6 complex is a DNA loop extruding motor |
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Dendrite branching receptor HPO-30 uses two novel mechanisms to regulate actin cytoskeletal remodeling |
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PROPOSE: Predictive and robust probe selection for spatial transcriptomics |
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In silico screening of novel senolytic compounds from natural food sources |
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Improved methods for the large-scale cultivation of Giardia lamblia trophozoites in the academic laboratory |
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Identification of two pyruvate transporters in Salmonella enterica serovar Typhimurium and their biological relevance |
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Antibiotic acyldepsipeptides stimulate the Streptomyces Clp-ATPase/ClpP complex for accelerated proteolysis |
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The Human Dendritic Cell Atlas: An integrated transcriptional tool to study human dendritic cell biology |
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Humoral immunity to SARS-CoV-2 elicited by combination COVID-19 vaccination regimens |
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Three-doses of BNT162b2 COVID-19 mRNA vaccine establishes long-lasting CD8+ T cell immunity in CLL and MDS patients |
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Astrocytic Gi-GPCR activation enhances stimulus-evoked extracellular glutamate |
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Transretinal migration of astrocytes and brain/spinal cord-like cells arising from transplanted human retinal organoids. |
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Evidence for a common mechanism supporting invigoration of action selection and action execution |
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Microglial P2X4 receptors promote ApoE degradation and cognitive deficits in Alzheimer disease |
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A critical role for spike synchrony in determining steep 1/f slopes in the setting of bursting EEG patterns |
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Flexible perceptual encoding by discrete gamma events |
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An Updated Gene Regulatory Network reconstruction of multidrug-resistant Pseudomonas aeruginosa CCBH4851 |
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Signal peptide efficiency: from high-throughput data to prediction and explanation |
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The cluster transfer function of AtNEET supports the ferredoxin-thioredoxin network of plant cells |
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No circadian clock-gene circuit in the generation of cellular bioluminescence rhythm of CaMV35S::PtRLUC in duckweed |
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Arabidopsis cell suspension culture that lacks circadian rhythms can be recovered by constitutive ELF3 expression |
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Trans-generational physiological condition of embryos is conditioned by maternal thermal stress in Octopus maya |
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Hypoxic memory of tumor intrinsic type I interferon suppression promotes breast cancer metastasis |
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Development of an antibody panel for imaging mass cytometry to investigate cancer-associated fibroblast heterogeneity and spatial distribution in archival tissues |
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VPS9D1-AS1 overexpression amplifies intratumoral TGF-β signaling and promotes tumor cell escape from CD8+ T cell killing in colorectal cancer |
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Cell-free Tumor Methylome Analysis of Small Cell Lung Cancer Patients Identifies Subgroups with Prognostic Associations |
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Polo-like kinase-1 Inhibitors and the Antiandrogen Abiraterone Synergistically Disrupt Mitosis and Kill Cancer Cells of Disparate Origin Independently of Androgen Receptor Signaling |
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Development and utility of a PAK1-selective degrader |
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Reversal of lactate and PD-1-mediated macrophage immunosuppression controls growth of PTEN/p53-deficient prostate cancer |
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ABL1 Kinase plays an important role in spontaneous and chemotherapy-induced genomic instability in multiple myeloma |
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MAP Kinase and mammalian target of rapamycin are main pathways of gallbladder carcinogenesis: Results from bioinformatic analysis of Next Generation Sequencing data from a hospital-based cohort. |
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Absorption changes in Photosystem II in the Soret band region upon the formation of the chlorophyll cation radical [PD1PD2]+ |
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Chimera States among Synchronous Fireflies |
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LAWS: Local Alignment for Water Sites -- tracking ordered water in simulations |
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Diffraction contrast in cryo-scanning transmission electron tomography reveals the boundary of hemozoin crystals in situ |
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Optimising Elastic Network Models for Protein Dynamics and Allostery: Spatial and Modal Cut-offs and Backbone Stiffness |
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Echolocation-like model of directed cell migrationwithin growing tissues |
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In situ architecture and membrane fusion of SARS-CoV-2 Delta variant |
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petiteFinder: An automated computer vision tool to compute Petite colony frequencies in baker's yeast |
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Identification of a gene signature to assess HSF1 transcriptional activity |
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N-ACT: An Interpretable Deep Learning Model for Automatic Cell Type and Salient Gene Identification |
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Comprehensive Analysis of the Expression and Prognosis for PSMBs in Clear Cell Renal Cell Carcinoma |
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SPACE-GM: geometric deep learning of disease-associated microenvironments from multiplex spatial protein profiles. |
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Tracking single cell evolution via clock-like chromatin accessibility |
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SCONCE2: jointly inferring single cell copy number profiles and tumor evolutionary distances |
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DNAscan2: a versatile, scalable, and user-friendly analysis pipeline for next-generation sequencing data |
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Systematic functional annotation workflow for insects |
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Using methylation data to improve transcription factor binding prediction |
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DirectMS1Quant: ultrafast quantitative proteomics with MS/MS-free mass spectrometry |
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neoMS: Attention-based Prediction of MHC-I Epitope Presentation |
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Antisense pairing and SNORD13 structure guide RNA cytidine acetylation |
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Species identification of early colonial bone artefacts excavated from Pyrmont, Australia, by mass spectrometric identification of collagen peptides |
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Conformational changes in mitochondrial complex I from the thermophilic eukaryote Chaetomium thermophilum |
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Translational Activity Controls Ribophagic Flux and Turnover of Distinct Ribosome Pools |
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Mouse primary T cell phosphotyrosine proteomics enabled by BOOST |
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Transcriptome analysis in the silkworm Bombyx mori overexpressing piRNA-resistant Masculinizer gene |
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A survey of lineage-specific genes in Triticeae reveals de novo gene evolution from genomic raw material |
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Accounting for intraspecific variation in continuous trait evolution on a reticulate phylogeny |
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Ancient DNA from the extinct New Zealand grayling (Prototroctes oxyrhynchus) reveals evidence for Miocene marine dispersal |
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Insights into the genomics of clownfish adaptive radiation: the genomic substrate of the diversification |
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Climatic niche evolution of infectious diseases driving amphibian declines |
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The limits to ecological limits to diversification |
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Low spontaneous mutation rate in a complex multicellular eukaryote with a haploid-diploid life cycle |
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Systemic pesticides in a solitary bee pollen food store affect larval development and increase pupal mortality |
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Modelling spatially autocorrelated detection probabilities in spatial capture-recapture using random effects |
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Modeling ecological communities when composition is manipulated experimentally |
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The wild life of ticks: using passive surveillance to determine the distribution and wildlife host range of ticks and the exotic Haemaphysalis longicornis, 2010-2021 |
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Simulating alternative forest management in a changing climate on a Pinus nigra subsp. laricio plantation in Southern Italy |
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Heme-deficient metabolism and impaired cellular differentiation as an evolutionary trade-off for human infectivity in Trypanosoma brucei gambiense |
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The H3K27me3 epigenetic mark is crucial for callus cell identity and for the acquisition of new fate during root and shoot regeneration |
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Differential integration of activation and repression signals in a multi-enhancer system |
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Centrosome Loss And Cell Proliferation Defects Underlie Developmental Failure In Haploid Zebrafish Larvae |
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Replication stress tolerance and management differs between naive and primed pluripotent cells |
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Dandy Walker-like malformations in mutant mice demonstrate a role for PDGF-C/PDGFRα signalling in cerebellar development |
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Computationally efficient mechanism discovery for cell invasion with uncertainty quantification |
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Differential modifications of the C-terminal tails of α-tubulin isoforms and their in vivo importance for kinesin function in Drosophila |
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Assessment of Human Renal Transporter Based Drug-Drug Interactions Using Proximal Tubule Kidney-Chip |
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Fat body-specific reduction of CTPS alleviates HFD-induced obesity |
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Mesenchymal Stromal Cells Donate Mitochondria to Articular Chondrocytes Exposed to Mitochondrial, Environmental, and Mechanical Stress |
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Galectin-9 interacts with Vamp-3 to regulate cytokine secretion in dendritic cells |
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Perturbation of ATP6V0A1 as a Driver and Druggable Target for Renal Proximal Tubular Cellular Injury in Nephropathic Cystinosis |
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Aberrant association of chromatin with nuclear periphery induced by Rif1 leads to mitotic defect and cell death. |
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Longitudinal comparison of the developing gut virome in infants and their mothers |
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Application and comparison of lyophilisation protocols to enhance stable long-term storage of filovirus pseudotypes for use in antibody neutralisation tests |
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The targeted deletion of genes responsible for expression of the Mth60 fimbriae leads to loss of cell-cell connections in M. thermautotrophicus ΔH |
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Development and Evaluation of a Colloidal Gold Immunofiltration Assay for Penside Diagnosis of Visceral Schistosomosis in Cattle |
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Neuro-immune Crosstalk in the Enteric Nervous System from Early Postnatal Development to Adulthood |
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Profile of Mycobacterium tuberculosis-specific CD4 T cells at the site of disease and blood in pericardial tuberculosis |
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A Multimodal Neuroimaging Dataset to Study Spatiotemporal Dynamics of Visual Processing in Humans |
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Macroscale Thalamic Functional Organization Disturbances And Underlying Core Cytoarchitecture In Early-Onset Schizophrenia |
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#PeerReview from @ReviewCommons of ???????? Fat Body Phospholipid State Dictates Hunger Driven Feeding Behavior |
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#PeerReview from @BiophysicsColab of ???????? Structural basis of ion - substrate coupling in the Na+-dependent dicarboxylate transporter VcINDY |
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#PeerReview from @ReviewCommons of ???????? Reorganization of F-actin nanostructures is required for the late phases of SARS-CoV-2 replication in pulmonary cells. |
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#PeerReview from @PeerCommunityIn of ???????? Riparian forest restoration as sources of biodiversity and ecosystem functions in anthropogenic landscapes |
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#PeerReview from @ReviewCommons of ???????? Transient regulation of focal adhesion via Tensin3 is required for nascent oligodendrocyte differentiation |
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Genome-wide selection inference at short tandem repeats |
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Tissue and cell-type specific molecular and functional signatures of 16p11.2 reciprocal genomic disorder across mouse brain and human neuronal models |
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Adult-born granule cells improve stimulus encoding and discrimination in the dentate gyrus |
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Modality specific roles for metabotropic GABAergic signaling and calcium induced calcium release mechanisms in regulating cold nociception |
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The length of the thalamo-cortical white matter fibers brings insight into sex differences in sleep spindle frequency |
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Increased sensorimotor structural connectivity in high schizotypy |
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Cerebellar motor memory expression requires learned alterations to the activity of inhibitory molecular layer interneurons |
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Foxd1 dependent induction of temporal retinal character is required for visual function |
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#PeerReview from @ReviewCommons of ???????? Continuous sensing of IFNα by hepatic endothelial cells shapes a vascular antimetastatic barrier |
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#PeerReview from @ASAPbio_ of ???????? Microtubule rescue at midzone edges promotes overlap stability and prevents spindle collapse during anaphase B |
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Deep learning-based approach for the characterization and quantification of histopathology in mouse models of colitis |
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Aspects of the glycome of endochondral ossification |
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Contrasting reproductive strategies despite convergent traits for two dryland river-floodplain species |
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Evaluating Stored Platelet Shape Change Using Imaging Flow Cytometry |
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Structure and mechanism of LARGE1 matriglycan polymerase |
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Stromal Hippo-YAP signaling in stem cell niche controls intestinal homeostasis |
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Ena/VASP clustering at microspike tips involves Lamellipodin but not I-BAR proteins, and absolutely requires unconventional Myosin-X |
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Proximity labelling identifies pro-migratory endocytic recycling cargo and machinery of the Rab4 and Rab11 families |
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Induced pluripotent stem cells and cerebral organoids from the critically endangered Sumatran rhinoceros |
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Drosophila melanogaster is a powerful host model to study mycobacterial virulence |
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Insulin-like Growth Factor-1 Synergizes with IL-2 to Induce Homeostatic Proliferation of Regulatory T cells |
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Cell-autonomous immune dysfunction driven by disrupted autophagy in C9orf72-ALS iPSC-derived microglia contributes to neurodegeneration |
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LDL1 and LDL2 histone demethylases interact with FVE to regulate flowering in Arabidopsis |
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RNA Methylome Reveals the m6A-Mediated Regulation of Flavor Metabolites in Tea Leaves under Solar-Withering |
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#PeerReview from @eLife of ???????? Systematic lncRNA mapping to genome-wide co-essential pathways uncovers cancer dependency on uncharacterized lncRNAs |
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#PeerReview from @eLife of ???????? WhyD tailors surface polymers to prevent bacteriolysis and direct cell elongation in Streptococcus pneumoniae |
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#PeerReview from @eLife of ???????? Quantitative MRI reveals differences in striatal myelin in children with DLD |
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#PeerReview from @eLife of ???????? The role of surface adhesion on the macroscopic wrinkling of biofilms |
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#PeerReview from @eLife of ???????? Spontaneous Neuronal Oscillations in the Human Insula are Hierarchically Organized Traveling Waves |
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#PeerReview from @eLife of ???????? Gill developmental program in the teleost mandibular arch |
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Uncovering the mechanism for aggregation in repeat expanded RNA reveals a reentrant transition |
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Structural basis underlying specific biochemical activities of non-muscle tropomyosin isoforms |
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Biophysical and functional characterization of K+-Cl- co-transporters from Drosophila melanogaster and Hydra vulgaris |
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Evaluation of metagenomic, 16S rRNA gene and ultra-plexed PCR-based sequencing approaches for profiling antimicrobial resistance gene and bacterial taxonomic composition of polymicrobial samples |
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Complexities of recapitulating polygenic effects in natural populations: replication of genetic effects on wing shape in artificially selected and wild caught populations of Drosophila melanogaster. |
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Turning coldspots into hotspots: targeted recruitment of axis protein Hop1 stimulates meiotic recombination in Saccharomyces cerevisiae |
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Strongly truncated Dnaaf4 plays a conserved role in Drosophila ciliary dynein assembly as part of an R2TP-like co-chaperone complex with Dnaaf6 |
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Myofiber reconstruction at micron scale reveals longitudinal bands in heart ventricular walls |
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Fob1-dependent condensin recruitment and loop extrusion on yeast chromosome III |
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Mapping the landscape of anti-phage defense mechanisms in the E. coli pangenome |
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Mapping the risk of Rift Valley fever in Uganda using national seroprevalence data from cattle, sheep and goats |
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Small-molecule inhibitors targeting prokaryotic ClpQ protease in Plasmodium display anti-malarial efficacies against blood and liver stages |
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Partner-assisted artificial selection of a secondary function for efficient bioremediation |
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Delineating the transcriptional landscape and clonal diversity of virus- specific CD4 + T cells during chronic viral infection |
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Proliferation is a driver of quorum sensing in an in vitro model of tissue resident macrophages |
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Characterization of full-length CNBP expanded alleles in myotonic dystrophy type 2 patients by Cas9-mediated enrichment and nanopore sequencing |
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A human and rhesus macaque interferon-stimulated gene screen reveals ARHGEF3/XPLN as an antiviral gene against hepatitis C virus and other flaviviruses |
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Delivery of Circular mRNA via Degradable Lipid Nanoparticles against SARS-COV-2 Delta Variant |
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The SARS-CoV-2 Spike Protein Activates the Epidermal Growth Factor Receptor-Mediated Signaling |
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Biochemical Characterization of Emerging SARS-CoV-2 Nsp15 Endoribonuclease Variants |
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Low immune response after 1.5 years of primary SARS-CoV-2 infection and Covishield vaccination lead to SARS-CoV-2 reinfection |
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A Mathematical Model of the Within-Host Kinetics of SARS-CoV-2 Neutralizing Antibodies Following COVID-19 Vaccination |
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A Bispecific Antibody Targeting RBD and S2 Potently Neutralizes SARS-CoV-2 Omicron and Other Variants of Concern |
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Effect on the conformations of spike protein of SARS-CoV-2 due to mutation |
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Contrasting patterns of genetic admixture explain the phylogeographic history of Iberian high mountain populations of midwife toads |
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Targeting Echinococcus multilocularis PIM kinase for improving anti-parasitic chemotherapy |
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Prenatal alcohol exposure alters axon formation and Robo/Slit guidance cue expression in the internal capsule at E15.5 |
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Functional connectivity dynamics reflect disability and multi-domain clinical impairment in patients with relapsing-remitting multiple sclerosis |
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AtlasXbrowser enables spatial multi-omics data analysis through the precise determination of the region of interest |
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Beyond the Euclidean brain: inferring non-Euclidean latent trajectories from spike trains |
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Deep Learning on Multimodal Chemical and Whole Slide Imaging Data for Predicting Prostate Cancer Directly from Tissue Images |
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Paths to adaptation under fluctuating nitrogen starvation: The spectrum of adaptive mutations in Saccharomyces cerevisiae is shaped by transposons and microhomology-mediated recombination |
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The homodimeric structure of the LARGE1 dual glycosyltransferase |
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Simplified fecal community transplant restores Clostridioides difficile colonization resistance to antibiotic perturbed murine communities |
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IL-13-programmed airway tuft cells produce PGE2, which promotes CFTR-dependent mucociliary function |
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Mapping odorant sensitivities reveals a sparse but structured representation of olfactory chemical space by sensory input to the mouse olfactory bulb. |
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Serotonin coordinates reproductive functions in Caenorhabditis elegans |
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Quantification of astrocytic synaptic pruning in hippocampus in response to in vitro Aβ oligomer incubation via colocalization analysis with C1q |
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Voluntary and forced exposure to ethanol vapor produces similar escalation of alcohol drinking but differential recruitment of brain regions related to stress, habit, and reward in male rats. |
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Optogenetic rejuvenation of mitochondrial membrane potential extends C. elegans lifespan |
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Proteogenomic characterization of age and sex interactions in cardiac gene expression |
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Pytri: A multi-weight detection system for biological entities |
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Rapid modeling of experimental molecular kinetics with simple electronic circuits instead of with complex differential equations |
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Potent activation of NAD+-dependent deacetylase Sirt7 by nucleosome binding |
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Effects of temperature on mating behaviour and mating success: a meta-analysis |
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Geodesics to characterize the phylogenetic landscape |
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Nuclear Ribosomal Internal Transcribed Spacer 1 (ITS1) variation in Lady Bird Beetles (Coccinellidae) |
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Fermented foods restructure gut microbiota and promote immune regulation via microbial metabolites |
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MicroRNAs contribute to the host response to Coxiella burnetii |
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B cell receptor stimulation induces IgE plasma cell apoptosis |
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Genome-wide analysis of dendritic cell differentiation |
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Sleep does not influence schema-facilitated motor memory consolidation |
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Infestation and growth of Tribolium confusum (Coleoptera: Tenebrionidae) on two varieties of local durum wheat: nutritional value and varietal susceptibility |
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A label-free method to track individuals and lineages of budding cells |
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Parasites, infections and inoculation in synthetic minimal cells |
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High throughput peptidomics elucidates immunoregulatory functions of plant thimet oligopeptidase-directed proteostasis |
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RFcaller: a machine learning approach combined with read-level features to detect somatic mutations |
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Vast heterogeneity in cytoplasmic diffusion rates revealed by nanorheology and Doppelgänger simulations |
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All the ways your eyes can move if you don't look: Eyeball lifting, retraction and compression during blinks |
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Gateway Identity and Spatial Remapping in a Combined Grid and Place Cell Attractor. |
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Strategic exploration in the macaque prefrontal cortex |
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Tethering distinct molecular profiles of single cells by their lineage histories to investigate sources of cell state heterogeneity |
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HumanMine: advanced data searching, analysis and cross-species comparison. |
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#PeerReview from @eLife of ???????? Generation and timing of graded responses to morphogen gradients |
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Eudicot primary cell wall glucomannan is related in synthesis, structure and function to xyloglucan |
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#PeerReview from @eLife of ???????? The origin of universal cell shape variability in a confluent epithelial monolayer |
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#PeerReview from @eLife of ???????? Genetic barriers to gene flow separate divergent substitution rates across a butterfly hybrid zone |
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RAS and PP2A activities converge on epigenetic gene regulation |
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#PeerReview from @eLife of ???????? ECM-integrin signalling instructs cellular position-sensing to pattern the early mouse embryo |
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#PeerReview from @eLife of ???????? Widespread introgression across a phylogeny of 155 Drosophila genomes |
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#PeerReview from @eLife of ???????? Nigrostriatal Dopamine Signals Sequence-Specific Action-Outcome Prediction Errors |
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Accelerating the clock: Interconnected speedup of energetic and molecular dynamics during aging in cultured human cells |
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Tau seeds translocate across the cell membrane to initiate aggregation |
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Neural signals encoded by specific frequencies of closed-loop electrical stimulation structurally and functionally reconstruct spinal sensorimotor circuits after spinal cord injury |
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Selective auditory attention modulates cortical responses to sound location change for speech in quiet and in babble |
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Data-driven microscopy allows for automated targeted acquisition of relevant data with higher fidelity |
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Hippocampus Modulates Natural Sound Processing at Early Auditory Centers |
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